Objective:The Chinese version of the Work Role Functioning Questionnaire 2.0 (WRFQ2.0) was translated and tested for reliability and validity in breast cancer patients in order to provide an assessment tool for accurately assessing perceived difficulties in breast cancer patients′ work need.Methods:This study was a cross-sectional study. According to Brislin model and two rounds of Delphi expert consultation, the WRFQ2.0 was sinicized. From January 2020 to June 2021, 200 patients with breast cancer in the Department of Nail and Breast Surgery of Kunshan Second People′s Hospital were selected for investigation, and test its reliability and validity.Results:The Chinese version of WRFQ2.0 extracted five factors, with a cumulative contribution rate of 79.995%. Cronbach′s α coefficient of the total questionnaire was 0.923, and the half-reliability of the total questionnaire was 0.908; the retest reliability was 0.904. The S-CVI value of the total questionnaire was 0.913, and the I-CVI value of each item was 0.798-1.000. The result of confirmatory factor analysis showed that the fitting index of the final model was: χ2/ df=2.013, Goodness of Fit Index=0.908, Root Mean Square Residual=0.041, Root Mean Square Error of Approximation=0.077, Comparative Fit Index=0.903, Normed Fit Index=0.904, suggesting that the model fitting effect was ideal. Conclusions:The Chinese version of WRFQ2.0 is reliable and valid, and can be used as an effective questionnaire to evaluate the working function of breast cancer patients in China.