Background and objective With further understanding and research into non-small cell lung cancer with tumours ≤2 cm in maximum diameter,segmental lung resection is able to achieve the same long-term prognosis as lobec-tomy.However,there are few studies on the prognostic effect of wedge resection on small volume invasive lung adenocarci-noma with an invasion depth of 0.5 to 1.0 cm.Therefore,this study focuses on the clinical efficacy and prognosis of wedge re-section in patients with small-volume invasive lung adenocarcinoma.Methods A retrospective analysis of the medical records of 208 patients who underwent surgery in the Department of Thoracic Surgery of the Affiliated Provincial Hospital of Anhui Medical University from February 2016 to December 2017 was made,and the postoperative pathological results confirmed small volume invasive lung adenocarcinoma.According to their surgical methods,they were divided into lobectomy group(n=115),segmentectomy group(n=48)and wedge resection group(n=45).Kaplan-Meier survival curve estimation and Cox proportional risk regression model were used to explore the influence of different surgical methods on the prognosis of patients with small volume invasive lung adenocarcinoma.Results The wedge resection group had better perioperative outcomes compared with the segmentectomy group and lobectomy group,with statistically significant differences in intraoperative bleed-ing(P=0.036),postoperative drainage(P＜0.001),operative time(P=0.018),postoperative time with tubes(P=0.001),and postoperative complication rate(P=0.006).There were no significant differences when comparing the three groups in terms of survival rate(lobectomy group vs segmentectomy group,P=0.303;lobectomy group vs wedge resection group,P=0.742;and segmentectomy group vs wedge resection group,P=0.278)and recurrence-free survival rate(lobectomy group vs segmentec-tomy group,P=0.495;lobectomy group vs wedge resection group,P=0.362;segmentectomy group vs wedge resection group,P=0.775).Univariate and multivariate survival analyses showed that consolidation tumor ratio(CTR)was the prognostic factor of overall survival and revurrence-free survival for patients with small-volume invasive lung adenocarcinoma(P＜0.05).Conclusion Wedge resection in patients with small volume invasive lung adenocarcinoma can achieve long-term outcomes similar to segmentectomy and lobectomy.When the CTR≤0.5,wedge resection is preferred in such patients.

Objective To develop a rapid and accurate Monte Carlo program(simplified code for dosimetry of carbon ions,SPEEDO)for carbon ion therapy.Methods For electromagnetic process,type Ⅱ condensed history simulation scheme and continuous slowing down approximation were used to simulate energy straggling,range straggling,multiple scattering,and ionization processes.For nuclear interaction,5 types of target nuclei were considered,including hydrogen,carbon,nitrogen,oxygen,and calcium.The produced secondary charged particles followed the same condensed history framework.The study simulated the transport of carbon ions in 4 materials(water,soft tissues,lung,and bone),and the calculated doses were validated against TOPAS(a Monte Carlo simulation software for radiotherapy physics),followed by a comparison with dose measurements in a water phantom from the HIMM-WW(a medical heavy-ion accelerator facility in Wuwei).Results SPEEDO's simulation results showed good consistency with TOPAS.For each material,in the voxel region where the physical dose was greater than 10％of the maximum dose point,the relative maximum dose error of both was less than 2％.At treatment energy of 400 MeV/u,SPEEDO's computation time was significantly less than that of TOPAS(13.8 min vs 105.0 min).SPEEDO's calculation results also showed good agreement with HIMM-WW measurements in terms of lateral dose distribution and integrated dose depth curve.Conclusion SPEEDO program can accurately and rapidly perform Monte Carlo dose calculations for carbon-ion therapy.

Objective To develop a GPU-based Monte Carlo dose calculation module for helical tomotherapy(TOMO),and integrate it into the commercial software ArcherQA to achieve fast and accurate dose verification in clinic.Methods The TOMO treatment head was modeled using TOPAS to obtain phase space files,and a fast weight tuning algorithm was used to simulate particle transport in multi-leaf collimator for improving computational efficiency,and finally,GPU-based Monte Carlo algorithms in ArcherQA were used to simulate particle transport in patients.To verify the model accuracy,the ArcherQA calculated results in water tank were compared with measured data for different open fields.In addition,multiple comparisons among ArcherQA results,TPS results and ArcCHECK results were conducted on 15 clinical cases(5 cases in the head and neck,5 cases in the chest and abdomen,and 5 cases in the whole body).Results In the water tank tests for 40 cm×5.0 cm,40 cm×2.5 cm and 40 cm× 1.0 cm radiation fields,the average global relative errors of the percentage depth dose,transverse dose distribution,and longitudinal dose distribution calculated by ArcherQA with the corresponding measured values were 0.72％,0.66％,and 0.54％,respectively.Over 98％of the voxels had a global relative error of less than 1％.As for 15 clinical cases,in 2％/2 mm criteria,the mean Gamma passing rate was 98.1％between ArcherQA and TPS,99.1％between TPS and ArcCHECK,and 99.4％between ArcherQA and ArcCHECK.The uncertainty of the simulation maintained less than 1％,and the average time taken for calculation based on patient CT vs ArcCHECK phantom was 87 s vs 64 s.Conclusion ArcherQA can be used for independent dose validation for TOMO plans for it can provide fast and accurate dose calculations.

OBJECTIVE To study the improvement effect and possible mechanism of N-butylphthalide on inflammatory injury of bone marrow mesenchymal stem cells （BMSCs） in rats. METHODS BMSCs of rats were divided into control group， model group， N-butylphthalide low-concentration， medium-concentration and high-concentration groups （10， 20， 50 μmol/L）. BMSCs were cultured in vitro and lipopolysaccharide （the final concentration of 10 mg/L） was used to establish the inflammatory injury model. After the intervention of N-butylphthalide， the survival rate， apoptotic rate， the contents of tumor necrosis factor α （TNF- α）， interleukin 1β （IL-1β） and IL-6 in cell culture medium， the mRNA expression of nuclear factor-κB（NF-κB） p65， and the protein expressions of caspase-3， B-cell lymphoma 2 （Bcl-2）， Bcl-2 related X protein （Bax） and NF-κB p65 in cells were detected. RESULTS Compared with control group， the survival rate and protein expression of Bcl-2 were decreased significantly in model group （P＜0.05）； the apoptotic rate， contents of TNF-α， IL-1β and IL-6， the mRNA expression of NF-κB p65， and the protein expressions of caspase-3， Bax and NF-κB p65 were increased significantly （P＜0.05）. Compared with model group， above indexes were significantly reversed in all concentration groups of N-butylphthalide （P＜0.05）， in concentration-dependent manner. CONCLUSIONS N-butylphthalide can ameliorate the inflammatory injury of BMSCs induced by lipopolysaccharide， and its mechanism may be related to the inhibition of NF-κB signaling pathway.

Objective:To explore the reform path of clinical laboratory technical talents training in local universities under the background of "New Medicine".Methods:The present situation of medical laboratory technical personnel training under the background of "New Medicine" was analyzed, and the teaching mode, teaching platform and practical teaching were reformed according to the reality of Guizhou Medical University.Results:An open education system of "healthcare-education collaboration and academia-industry alliances" and the talent training mode of "three-oriented drive, four-sided integration" had been formed, which improved the training quality and provided a large number of qualified medical laboratory technical undergraduate talents to the grass-roots of Guizhou Medical System.Conclusion:The reform and practice of applied talent training in Guizhou Medical University can be used as a reference for local colleges and universities to educate applied medical laboratory technical talents.

The goal of this paper is to solve the problems of large volume, slow dynamic response and poor intelligent controllability of traditional gait rehabilitation training equipment by using the characteristic that the shear yield strength of magnetorheological fluid changes with the applied magnetic field strength. Based on the extended Bingham model, the main structural parameters of the magnetorheological fluid damper and its output force were simulated and optimized by using scientific computing software, and the three-dimensional modeling of the damper was carried out after the size was determined. On this basis and according to the design and use requirements of the damper, the finite element analysis software was used for force analysis, strength check and topology optimization of the main force components. Finally, a micro magnetorheological fluid damper suitable for wearable rehabilitation training system was designed, which has reference value for the design of lightweight, portable and intelligent rehabilitation training equipment.
Computer Simulation ; Software ; Wearable Electronic Devices

Objective:To discuss the effect and prognostic factors of immediate facial nerve rehabilitation in malignant parotid gland tumor surgery.Methods:The patients with malignant parotid gland tumor who underwent facial nerve rehabilitation surgery in Peking University School and Hospital of Stomatology from January 2004 to July 2020 were retrospectively analyzed. Their demographic characteristics, preoperative and postoperative facial nerve function according to the House-Brackmann (HB) facial nerve grading system from HB grade Ⅰ to HB grade Ⅵ, injury sites of facial nerve including the trunks injury and branches injury, surgical timing including immediate rehabilitation and elective rehabilitation and rehabilitation methods such as facial nerve anastomosis, nerve transplantation, nerve transfer and muscle flap suspension were recorded. Patients were divided into two groups: satisfactory outcomes with HB grades Ⅰ-Ⅲ and unsatisfactory outcomes with HB grades Ⅳ-Ⅵ, and the factors that may affect the prognosis of facial nerve function were statistically analyzed. T-test was used to compare measurement data, chi-square test or Fisher’s precision probability test was used to compare count data. P<0.05 was considered statistically significant. Results:Eighty-nine patients were included in the study, including 50 males and 39 females, aged 9-82 years, the median age was 49.0 years. Preoperative facial nerve function outcomes were HB Ⅰ ( n=57), HB Ⅱ ( n=5), HB Ⅲ ( n=8), HB Ⅳ ( n=2), HB Ⅴ ( n=15) and HB Ⅵ ( n=2). Fifty-seven patients underwent immediate rehabilitation and 32 patients received elective rehabilitation. In 53 cases, the main trunk and/or the temporal and cervical trunk were injured, and 36 cases were branches injury. Facial nerve anastomosis was performed in 35 cases, 39 cases required nerve transplantation, 12 cases underwent nerve transfer, and 3 cases underwent muscle flap suspension. The follow-up time was 6-72 months. Postoperative facial nerve function outcomes were HB Ⅰ ( n=6), HB Ⅱ ( n=17), HB Ⅲ ( n=26), HB Ⅳ ( n=27), and HB Ⅴ ( n=13). Forty-nine cases were classified as group with postoperative HB grades Ⅰ-Ⅲ, and 40 cases were classified as group with postoperative HB grades Ⅳ-Ⅵ. Statistical analysis showed that there was no significant difference in terms of age and gender between two groups ( P>0.05). Among the patients with postoperative HB grades Ⅰ-Ⅲ, 73.5% (36/49) of the patients had immediate rehabilitation, 36.7% (18/49) of the patients had injury of the nerve trunks, 89.8% (44/49) of the patients had preoperative HB grades Ⅰ-Ⅲ, and 59.2% (29/49) of the patients had nerve anastomosis. Among the patients with postoperative HB grades Ⅳ-Ⅵ, 52.5% (21/40) of the patients had immediate rehabilitation, 87.5% (35/40) of the patients had injury of the nerve trunks, 65.0% (26/40) of the patients had preoperative HB gradesⅠ-Ⅲ, and 15.0% (6/40) of the patients had nerve anastomosis were in the group. There were statistically significant differences between the two groups ( P<0.05 or <0.01). Conclusions:Immediate reconstruction of the facial nerve defect during the operation of malignant parotid gland tumor can obtain better result. Furthermore, injury sites of facial nerve may affect the prognosis of facial nerve function as well.

Objective:To discuss the effect and prognostic factors of immediate facial nerve rehabilitation in malignant parotid gland tumor surgery.Methods:The patients with malignant parotid gland tumor who underwent facial nerve rehabilitation surgery in Peking University School and Hospital of Stomatology from January 2004 to July 2020 were retrospectively analyzed. Their demographic characteristics, preoperative and postoperative facial nerve function according to the House-Brackmann (HB) facial nerve grading system from HB grade Ⅰ to HB grade Ⅵ, injury sites of facial nerve including the trunks injury and branches injury, surgical timing including immediate rehabilitation and elective rehabilitation and rehabilitation methods such as facial nerve anastomosis, nerve transplantation, nerve transfer and muscle flap suspension were recorded. Patients were divided into two groups: satisfactory outcomes with HB grades Ⅰ-Ⅲ and unsatisfactory outcomes with HB grades Ⅳ-Ⅵ, and the factors that may affect the prognosis of facial nerve function were statistically analyzed. T-test was used to compare measurement data, chi-square test or Fisher’s precision probability test was used to compare count data. P<0.05 was considered statistically significant. Results:Eighty-nine patients were included in the study, including 50 males and 39 females, aged 9-82 years, the median age was 49.0 years. Preoperative facial nerve function outcomes were HB Ⅰ ( n=57), HB Ⅱ ( n=5), HB Ⅲ ( n=8), HB Ⅳ ( n=2), HB Ⅴ ( n=15) and HB Ⅵ ( n=2). Fifty-seven patients underwent immediate rehabilitation and 32 patients received elective rehabilitation. In 53 cases, the main trunk and/or the temporal and cervical trunk were injured, and 36 cases were branches injury. Facial nerve anastomosis was performed in 35 cases, 39 cases required nerve transplantation, 12 cases underwent nerve transfer, and 3 cases underwent muscle flap suspension. The follow-up time was 6-72 months. Postoperative facial nerve function outcomes were HB Ⅰ ( n=6), HB Ⅱ ( n=17), HB Ⅲ ( n=26), HB Ⅳ ( n=27), and HB Ⅴ ( n=13). Forty-nine cases were classified as group with postoperative HB grades Ⅰ-Ⅲ, and 40 cases were classified as group with postoperative HB grades Ⅳ-Ⅵ. Statistical analysis showed that there was no significant difference in terms of age and gender between two groups ( P>0.05). Among the patients with postoperative HB grades Ⅰ-Ⅲ, 73.5% (36/49) of the patients had immediate rehabilitation, 36.7% (18/49) of the patients had injury of the nerve trunks, 89.8% (44/49) of the patients had preoperative HB grades Ⅰ-Ⅲ, and 59.2% (29/49) of the patients had nerve anastomosis. Among the patients with postoperative HB grades Ⅳ-Ⅵ, 52.5% (21/40) of the patients had immediate rehabilitation, 87.5% (35/40) of the patients had injury of the nerve trunks, 65.0% (26/40) of the patients had preoperative HB gradesⅠ-Ⅲ, and 15.0% (6/40) of the patients had nerve anastomosis were in the group. There were statistically significant differences between the two groups ( P<0.05 or <0.01). Conclusions:Immediate reconstruction of the facial nerve defect during the operation of malignant parotid gland tumor can obtain better result. Furthermore, injury sites of facial nerve may affect the prognosis of facial nerve function as well.

Objective:To evaluate the efficacy of postoperative radiotherapy (PRT) for dermatofibrosarcoma protuberans (DFSP).Methods:A systematic review and meta-analysis of articles published before February 23, 2019 were conducted. A total of 655 studies were retrieved consisting of 195 DFSP patients. Among them, 50 cases were assigned into the PRT group and 145 cases in the surgery alone (SA) group. The recurrence rate was statistically compared between two group.Results:Meta-analysis showed that the recurrence rate in the PRT group was significantly lower than that in the SA group (8% vs. 24.1%, OR=0.28, P=0.010). The recurrence rate of patients with positive margins in the PRT group was significantly lower compared with that in the SA group (8% vs. 61.5%, P=0.002). The recurrence rate of patients with negative margins in the PRT group had a decreasing trend than that in the SA group (6% vs. 21.6%, P=0.205). Conclusions:The recurrence rate of surgery combined with PRT is lower than that of SA. The recurrence rate of patients with positive margins is higher than that of those with negative margins. For patients with positive margins, PRT can decrease the recurrence rate. The recurrence rate trends to decline in patients with negative margins after receiving PRT.

Objective To observe the clinical effects of breaking blood expelling stasis method of traditional Chinese medicine (TCM) combined with edaravone on patients with acute hypertensive intra-cerebral hemorrhage and preliminarily discuss its protection mechanism on this disease. Methods Ninety-two patients with hypertensive intra-cerebral hemorrhage within 72 hours after occurrence admitted to Zengcheng District People's Hosipital of Guangzhou from May 2013 to December 2017 were enrolled, they were divided into conventional therapy group and combined treatment of TCM and western medicine group by random numbers produced by a computer, 46 cases in each group. The conventional therapy group was treated with conventional therapy, and the combined treatment of TCM and western medicine group was treated with conventional therapy, additionally the treatment of Poxue Zhuyu decoction (the ingredients of the decoction: leech 10 g, gradfly 10 g, rhubarb 15 g, cattail pollen 5 g, trichosanthes fruit 10 g, radix notoginseng 5 g, colla plastri testudinis 10 g, grassleaf sweetflag rhizome 10 g, ground beetle 3 g, dried lacquer 3 g, peach seed 10 g) and edaravone for 10 days. The levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in serum were tested by enzyme-linked immunosorbent assay (ELISA) before and 7 days after treatment in the two groups; and the differences in National Institutes of Health stroke scale score (NIHSS) before and 14 days, 90 days after treatment as well as the changes of brain edema around the hematoma 14 days after treatment were compared between the two groups, and the incidence of adverse reaction was observed. Results After treatment, the levels of TNF-α, IL-6 and intra-cerebral hemorrhage quantities in the two groups were all decreased compared with those before treatment, and the degrees of decrease of TNF-α and cerebral hemorrhage volume in combined treatment of TCM and western medicine group were more significant than those in the conventional treatment group [TNF-α (ng/L): 21.00±6.10 vs. 29.40±11.33, cerebral hemorrhage volume (mL): 5.23±0.60 vs. 8.50±0.64, both P <0.05]. The IL-6 in the two groups were recovered to approximately normal levels after the treatment (ng/L: 13.60±5.36 vs. 15.40±6.13, P > 0.05). With the prolongation of therapeutic time, the scores of NIHSS of the two groups were significantly lowered than those before treatment, and the degree of reduction in the combined TCM and western medicine group on 90 days after treatment was more obvious than that of the conventional treatment group (4.34±0.67 vs. 7.73±0.61, P < 0.05). The volumes of edema around hematomas were increased after treatment in the two groups, but the degree of increase in combined treatment of TCM and western medicine group was slower than that of the conventional group (cm3: 7.57±0.64 vs. 10.16±0.60, P < 0.05). There was no statistical significant difference in the incidence of adverse reactions in comparison between the combined treatment of TCM and western medicine group and conventional therapy group [18.2% (8/44) vs. 20.5% (9/44), P > 0.05]. Conclusions Using breaking blood expelling stasis and edaravone for treatment of acute hypertensive intra-cerebral hemorrhage can accelerate the absorption of brain hematoma and improve the neurological function, and its mechanism may be relevant to the inhibition of some inflammatory factors.