Refractory mycoplasma pneumoniae pneumonia(RMPP) is a common type of community-acquired pneumonia in children which seriously influence children′s physical and mental health.There is no uniform diagnostic criteria.The clinical manifestations were fever, cough and other clinical symptoms 7 days after regular application of macrolides.Lung imaging showed progressive exaceration.Some patients are not treated timely because of lack of specific diagnostic criteria and left pulmonary sequelae eventually, which affect the quality of life seriously.Related researches of RMPP are emerging in recent years.This paper reviews the laboratory diagnosis, pathogenesis, clinical features and treatment of RMPP.