Objective:To investigate the influencing factors of asthma recurrence in preschool children.Methods:From January 2019 to December 2020, a total of 160 preschool children with asthma in the pediatric inpatient department of the Third People′s Hospital of Henan Province were included as the research subjects. After standardized treatment, the drug was discontinued and the patients were followed up for 1 year. A total of 6 cases were lost or withdrawn during the follow-up, and finally 154 cases were included and divided into recurrence group (91 cases) and non-recurrence group (63 cases) according to the presence or absence of recurrence. The data of these children were collected and recorded, and logistic regression analysis was used to explore the influencing factors of asthma recurrence in children, and to explore the corresponding intervention strategies.Results:The results of univariate analysis showed that the differences in guardian′s education level, asthma family history, asthma severity, coexisting allergic rhinitis, coexisting sinusitis, standardized medication course, combined medication, drug withdrawal season, adherence to regular follow-up visits, etc. were statistically significant between the two groups of asthmatic children (all P<0.05). Multivariate Logistic regression analysis showed that the children′s guardians had low educational level (junior high school and below) ( OR=1.960, 95% CI: 1.714-2.206), family history of asthma ( OR=2.277, 95% CI: 1.850-2.705), coexisting allergic rhinitis ( OR=2.034, 95% CI: 1.520-2.548), severe asthma ( OR=1.866, 95% CI: 1.026-2.707), drug withdrawal in spring or winter ( OR=1.861, 95% CI: 1.704-2.018) were risk factors for asthma recurrence, while standard medication duration >12 months ( OR=0.465, 95% CI: 0.304-0.712), combined medication ( OR=0.458, 95% CI: 0.297-0.705), adherence to regular follow-up visits ( OR=0.559, 95% CI: 0.389-0.803) were protective factors for asthma recurrence in children (all P<0.05). Conclusion:Family history of asthma, coexistence of allergic rhinitis, severity of asthma, adherence to regular follow-up visits, and standardized and combined medication are the main factors affecting asthma recurrence in preschool children, and clinical intervention strategies can be formulated accordingly.