This study analyzed the prevalence of metabolic syndrome and influencing factors among adult workers aged 19 to 64. Methods: Data from the ninth Korea National Health and Nutrition Examination Survey conducted in 2022 were utilized. The sample comprised 685 individuals who had measurements of fasting glucose, triglycerides, high-density lipoprotein cholesterol, blood pressure, and waist circumference, which are necessary to diagnose metabolic syndrome. Data analysis was performed using SPSS 26.0, and complex sample logistic regression was conducted to identify factors influencing metabolic syndrome. Results: Among the participants, 34.3% were diagnosed with metabolic syndrome. Significant differences were observed in sex, age, region, marital status, regular worker, and physical activity between participants with and without metabolic syndrome (p < .05). Factors influencing the prevalence of metabolic syndrome included sex, age (with the 19~29 age group showing a significantly lower risk), physical activity, smoking, and perceived stress levels (p < .05). Conclusion: To prevent metabolic syndrome in adult workers, it is essential to promote physical activity, discourage smoking, and encourage effective stress management.

This study analyzed the prevalence of metabolic syndrome and influencing factors among adult workers aged 19 to 64. Methods: Data from the ninth Korea National Health and Nutrition Examination Survey conducted in 2022 were utilized. The sample comprised 685 individuals who had measurements of fasting glucose, triglycerides, high-density lipoprotein cholesterol, blood pressure, and waist circumference, which are necessary to diagnose metabolic syndrome. Data analysis was performed using SPSS 26.0, and complex sample logistic regression was conducted to identify factors influencing metabolic syndrome. Results: Among the participants, 34.3% were diagnosed with metabolic syndrome. Significant differences were observed in sex, age, region, marital status, regular worker, and physical activity between participants with and without metabolic syndrome (p < .05). Factors influencing the prevalence of metabolic syndrome included sex, age (with the 19~29 age group showing a significantly lower risk), physical activity, smoking, and perceived stress levels (p < .05). Conclusion: To prevent metabolic syndrome in adult workers, it is essential to promote physical activity, discourage smoking, and encourage effective stress management.

Objective: This study aimed to evaluate the therapeutic role of lymphadenectomy in patients surgically treated for clinically early-stage epithelial ovarian cancer (EOC). Methods: This retrospective, multicenter study included patients with clinically earlystage EOC based on preoperative abdominal-pelvic computed tomography or magnetic resonance imaging findings between 2007 and 2021. Oncologic outcomes and perioperative complications were compared between the lymphadenectomy and non-lymphadenectomy groups. Independent prognostic factors were determined using Cox regression analysis.Disease-free survival (DFS) was the primary outcome. Overall survival (OS) and perioperative outcomes were the secondary outcomes. Results: In total, 586 patients (lymphadenectomy group, n=453 [77.3%]; nonlymphadenectomy groups, n=133 [22.7%]) were eligible. After surgical staging, upstaging was identified based on the presence of lymph node metastasis in 14 (3.1%) of 453 patients.No significant difference was found in the 5-year DFS (88.9% vs. 83.4%, p=0.203) and 5-year OS (97.2% vs. 97.7%, p=0.895) between the two groups. Using multivariable analysis, lymphadenectomy was not significantly associated with DFS or OS. However, using subgroup analysis, the lymphadenectomy group with serous histology had higher 5-year DFS rates than did the non-lymphadenectomy group (86.5% vs. 74.4%, p=0.048; adjusted hazard ratio=0.281; 95% confidence interval=0.107–0.735; p=0.010). The lymphadenectomy group had longer operating time (p<0.001), higher estimated blood loss (p<0.001), and higher perioperative complication rate (p=0.004) than did the non-lymphadenectomy group. Conclusion In patients with clinically early-stage EOC with serous histology, lymphadenectomy was associated with survival benefits. Considering its potential harm,

Objective: This study aimed to evaluate the therapeutic role of lymphadenectomy in patients surgically treated for clinically early-stage epithelial ovarian cancer (EOC). Methods: This retrospective, multicenter study included patients with clinically earlystage EOC based on preoperative abdominal-pelvic computed tomography or magnetic resonance imaging findings between 2007 and 2021. Oncologic outcomes and perioperative complications were compared between the lymphadenectomy and non-lymphadenectomy groups. Independent prognostic factors were determined using Cox regression analysis.Disease-free survival (DFS) was the primary outcome. Overall survival (OS) and perioperative outcomes were the secondary outcomes. Results: In total, 586 patients (lymphadenectomy group, n=453 [77.3%]; nonlymphadenectomy groups, n=133 [22.7%]) were eligible. After surgical staging, upstaging was identified based on the presence of lymph node metastasis in 14 (3.1%) of 453 patients.No significant difference was found in the 5-year DFS (88.9% vs. 83.4%, p=0.203) and 5-year OS (97.2% vs. 97.7%, p=0.895) between the two groups. Using multivariable analysis, lymphadenectomy was not significantly associated with DFS or OS. However, using subgroup analysis, the lymphadenectomy group with serous histology had higher 5-year DFS rates than did the non-lymphadenectomy group (86.5% vs. 74.4%, p=0.048; adjusted hazard ratio=0.281; 95% confidence interval=0.107–0.735; p=0.010). The lymphadenectomy group had longer operating time (p<0.001), higher estimated blood loss (p<0.001), and higher perioperative complication rate (p=0.004) than did the non-lymphadenectomy group. Conclusion In patients with clinically early-stage EOC with serous histology, lymphadenectomy was associated with survival benefits. Considering its potential harm,

This study analyzed the prevalence of metabolic syndrome and influencing factors among adult workers aged 19 to 64. Methods: Data from the ninth Korea National Health and Nutrition Examination Survey conducted in 2022 were utilized. The sample comprised 685 individuals who had measurements of fasting glucose, triglycerides, high-density lipoprotein cholesterol, blood pressure, and waist circumference, which are necessary to diagnose metabolic syndrome. Data analysis was performed using SPSS 26.0, and complex sample logistic regression was conducted to identify factors influencing metabolic syndrome. Results: Among the participants, 34.3% were diagnosed with metabolic syndrome. Significant differences were observed in sex, age, region, marital status, regular worker, and physical activity between participants with and without metabolic syndrome (p < .05). Factors influencing the prevalence of metabolic syndrome included sex, age (with the 19~29 age group showing a significantly lower risk), physical activity, smoking, and perceived stress levels (p < .05). Conclusion: To prevent metabolic syndrome in adult workers, it is essential to promote physical activity, discourage smoking, and encourage effective stress management.

Objective: This study aimed to evaluate the therapeutic role of lymphadenectomy in patients surgically treated for clinically early-stage epithelial ovarian cancer (EOC). Methods: This retrospective, multicenter study included patients with clinically earlystage EOC based on preoperative abdominal-pelvic computed tomography or magnetic resonance imaging findings between 2007 and 2021. Oncologic outcomes and perioperative complications were compared between the lymphadenectomy and non-lymphadenectomy groups. Independent prognostic factors were determined using Cox regression analysis.Disease-free survival (DFS) was the primary outcome. Overall survival (OS) and perioperative outcomes were the secondary outcomes. Results: In total, 586 patients (lymphadenectomy group, n=453 [77.3%]; nonlymphadenectomy groups, n=133 [22.7%]) were eligible. After surgical staging, upstaging was identified based on the presence of lymph node metastasis in 14 (3.1%) of 453 patients.No significant difference was found in the 5-year DFS (88.9% vs. 83.4%, p=0.203) and 5-year OS (97.2% vs. 97.7%, p=0.895) between the two groups. Using multivariable analysis, lymphadenectomy was not significantly associated with DFS or OS. However, using subgroup analysis, the lymphadenectomy group with serous histology had higher 5-year DFS rates than did the non-lymphadenectomy group (86.5% vs. 74.4%, p=0.048; adjusted hazard ratio=0.281; 95% confidence interval=0.107–0.735; p=0.010). The lymphadenectomy group had longer operating time (p<0.001), higher estimated blood loss (p<0.001), and higher perioperative complication rate (p=0.004) than did the non-lymphadenectomy group. Conclusion In patients with clinically early-stage EOC with serous histology, lymphadenectomy was associated with survival benefits. Considering its potential harm,

This study analyzed the prevalence of metabolic syndrome and influencing factors among adult workers aged 19 to 64. Methods: Data from the ninth Korea National Health and Nutrition Examination Survey conducted in 2022 were utilized. The sample comprised 685 individuals who had measurements of fasting glucose, triglycerides, high-density lipoprotein cholesterol, blood pressure, and waist circumference, which are necessary to diagnose metabolic syndrome. Data analysis was performed using SPSS 26.0, and complex sample logistic regression was conducted to identify factors influencing metabolic syndrome. Results: Among the participants, 34.3% were diagnosed with metabolic syndrome. Significant differences were observed in sex, age, region, marital status, regular worker, and physical activity between participants with and without metabolic syndrome (p < .05). Factors influencing the prevalence of metabolic syndrome included sex, age (with the 19~29 age group showing a significantly lower risk), physical activity, smoking, and perceived stress levels (p < .05). Conclusion: To prevent metabolic syndrome in adult workers, it is essential to promote physical activity, discourage smoking, and encourage effective stress management.

Gastric cancer is one of the most common cancers in Korea and the world. Since 2004, this is the 4th gastric cancer guideline published in Korea which is the revised version of previous evidence-based approach in 2018. Current guideline is a collaborative work of the interdisciplinary working group including experts in the field of gastric surgery, gastroenterology, endoscopy, medical oncology, abdominal radiology, pathology, nuclear medicine, radiation oncology and guideline development methodology. Total of 33 key questions were updated or proposed after a collaborative review by the working group and 40 statements were developed according to the systematic review using the MEDLINE, Embase, Cochrane Library and KoreaMed database. The level of evidence and the grading of recommendations were categorized according to the Grading of Recommendations, Assessment, Development and Evaluation proposition. Evidence level, benefit, harm, and clinical applicability was considered as the significant factors for recommendation. The working group reviewed recommendations and discussed for consensus. In the earlier part, general consideration discusses screening, diagnosis and staging of endoscopy, pathology, radiology, and nuclear medicine. Flowchart is depicted with statements which is supported by meta-analysis and references. Since clinical trial and systematic review was not suitable for postoperative oncologic and nutritional follow-up, working group agreed to conduct a nationwide survey investigating the clinical practice of all tertiary or general hospitals in Korea. The purpose of this survey was to provide baseline information on follow up. Herein we present a multidisciplinary-evidence based gastric cancer guideline.

Background: We conducted a comprehensive meta-analysis of prospective cohort studies to analyze the effect of circulating vitamin D level on the risk of sudden cardiac death (SCD) and cardiovascular disease (CVD) mortality. Methods: Prospective cohort studies evaluating the association between circulating vitamin D and risk of SCD and CVD mortality were systematically searched in the PubMed and Embase. Extracted data were analyzed using a random effects model and results were expressed in terms of hazard ratio (HR) and 95% confidence interval (CI). Restricted cubic spline analysis was used to estimate the dose-response relationships. Results: Of the 1,321 records identified using the search strategy, a total of 19 cohort studies were included in the final meta-analysis. The pooled estimate of HR (95% CI) for low vs. high circulating vitamin D level was 1.75 (1.49–2.06) with I 2 value of 30.4%. In subgroup analysis, strong effects of circulating vitamin D were observed in healthy general population (pooled HR, 1.84; 95% CI, 1.43–2.38) and the clinical endpoint of SCD (pooled HRs, 2.68; 95% CI, 1.48– 4.83). The dose-response analysis at the reference level of < 50 nmol/L showed a significant negative association between circulating vitamin D and risk of SCD and CVD mortality. Conclusion Our meta-analysis of prospective cohort studies showed that lower circulating vitamin D level significantly increased the risk of SCD and CVD mortality.