Objective: This study aims to validate the Korean version of Geriatric Suicide Ideation Scale-Screen (K-GSIS-Screen) and evaluate its clinical utility for screening suicidal ideation and risk among older adults across clinical and community settings. Methods: GSIS-Screen was translated into Korean and administered to 50 community-residing older adults and 49 elderly patients attending a depression clinic in the psychiatric department of a hospital. Reliability and validity were assessed by Cron-bach’s α and exploratory factor analysis. Then, clinical utility was further examined through receiver operating characteristic(ROC) curve analysis. Results: Exploratory factor analysis confirmed a single-factor structure. Overall findings demonstrated moderate to strong in-ternal consistency, convergent validity, and discriminant validity across community and clinical settings. Additionally, K-GSISScreen differentiated between older adults with and without suicidal ideation, with those in the former group scoring higher.ROC analysis confirmed an area under curve of 0.81. Conclusion The K-GSIS-Screen appears to be a useful primary screening tool for detecting suicidal ideation among older adults. It has the potential to facilitate rapid identification of suicidal ideation in clinical and community settings, thereby sup-porting early and appropriate interventions.

Objective: This study aims to validate the Korean version of Geriatric Suicide Ideation Scale-Screen (K-GSIS-Screen) and evaluate its clinical utility for screening suicidal ideation and risk among older adults across clinical and community settings. Methods: GSIS-Screen was translated into Korean and administered to 50 community-residing older adults and 49 elderly patients attending a depression clinic in the psychiatric department of a hospital. Reliability and validity were assessed by Cron-bach’s α and exploratory factor analysis. Then, clinical utility was further examined through receiver operating characteristic(ROC) curve analysis. Results: Exploratory factor analysis confirmed a single-factor structure. Overall findings demonstrated moderate to strong in-ternal consistency, convergent validity, and discriminant validity across community and clinical settings. Additionally, K-GSISScreen differentiated between older adults with and without suicidal ideation, with those in the former group scoring higher.ROC analysis confirmed an area under curve of 0.81. Conclusion The K-GSIS-Screen appears to be a useful primary screening tool for detecting suicidal ideation among older adults. It has the potential to facilitate rapid identification of suicidal ideation in clinical and community settings, thereby sup-porting early and appropriate interventions.

Objective: This study aims to validate the Korean version of Geriatric Suicide Ideation Scale-Screen (K-GSIS-Screen) and evaluate its clinical utility for screening suicidal ideation and risk among older adults across clinical and community settings. Methods: GSIS-Screen was translated into Korean and administered to 50 community-residing older adults and 49 elderly patients attending a depression clinic in the psychiatric department of a hospital. Reliability and validity were assessed by Cron-bach’s α and exploratory factor analysis. Then, clinical utility was further examined through receiver operating characteristic(ROC) curve analysis. Results: Exploratory factor analysis confirmed a single-factor structure. Overall findings demonstrated moderate to strong in-ternal consistency, convergent validity, and discriminant validity across community and clinical settings. Additionally, K-GSISScreen differentiated between older adults with and without suicidal ideation, with those in the former group scoring higher.ROC analysis confirmed an area under curve of 0.81. Conclusion The K-GSIS-Screen appears to be a useful primary screening tool for detecting suicidal ideation among older adults. It has the potential to facilitate rapid identification of suicidal ideation in clinical and community settings, thereby sup-porting early and appropriate interventions.

Objective: This study aims to validate the Korean version of Geriatric Suicide Ideation Scale-Screen (K-GSIS-Screen) and evaluate its clinical utility for screening suicidal ideation and risk among older adults across clinical and community settings. Methods: GSIS-Screen was translated into Korean and administered to 50 community-residing older adults and 49 elderly patients attending a depression clinic in the psychiatric department of a hospital. Reliability and validity were assessed by Cron-bach’s α and exploratory factor analysis. Then, clinical utility was further examined through receiver operating characteristic(ROC) curve analysis. Results: Exploratory factor analysis confirmed a single-factor structure. Overall findings demonstrated moderate to strong in-ternal consistency, convergent validity, and discriminant validity across community and clinical settings. Additionally, K-GSISScreen differentiated between older adults with and without suicidal ideation, with those in the former group scoring higher.ROC analysis confirmed an area under curve of 0.81. Conclusion The K-GSIS-Screen appears to be a useful primary screening tool for detecting suicidal ideation among older adults. It has the potential to facilitate rapid identification of suicidal ideation in clinical and community settings, thereby sup-porting early and appropriate interventions.

Background: Although there are growing demands for stem cell-based therapy for companion animals in various diseases, a few clinical trials have been reported. Moreover, most of them are the results from only one or a few times of stem cell injection. Objectives: The aim of this study is to describe a long-term treatment with allogeneic adipose-derived stem cells (ASCs) in a dog with rheumatoid arthritis (RA), which is a rare canine disease. Methods: The dog with RA received intravascular injection of allogeneic ASCs derived from two healthy donors once a month for 11 months. To assess therapeutic effects of ASCs, orthopedic examination and clinical evaluation was performed. Cytokines of tumor necrosis factor-α and interleukin-6 in the plasma were measured using ELISA analysis. Results: Despite this repeated and long-term administration of allogeneic ASCs, there were no side effects such as immunorejection responses or cell toxicity. The orthopedic examination score for the dog decreased after ASCs treatment, and the clinical condition of the dog and owner’s satisfaction were very good Conclusions Although ASCs has been suggested as one of the options for RA treatment because of its anti-inflammatory and immunosuppressive functions, it has never been used to treat RA in dogs. The present report describes a case of canine RA treated with allogeneic ASCs for long-term in which the dog showed clinical improvement without adverse effects.

Objective: PD-1 inhibitors have demonstrated improved health outcomes in cancer patients. PD-1 inhibitors are well-tolerated and associated with immune-related adverse events. The objectives of this study are to analyze use patterns of PD-1 inhibitors in patients with cancer and to investigate the incidence of thyroid-related adverse reactions in patients treated with PD-1 inhibitors. Methods: The study included patients who had been administered PD-1 inhibitors (either nivolumab or pembrolizumab) at the Samsung Medical Center between October 1, 2016 and June 30, 2017. Data was collected from electronic medical records and tested using Mann-Whitney tests and Chi-Square tests for statistical significance. Associations between PD-1 inhibitors and incidence of adverse events were tested using Cox regression for age, gender, BMI, ECOG PS and medication. Results: Two hundred fifteen patients were identified as eligible for analyses. Thyroid-related adverse events occurred in 20% of patients (n=43). Thyroid function tests (TFTs) was performed in 109 patients (50.7%). Positive results of PD-L1 testing were found in 53.2% of the 94 patients who had the test. Approved doses of nivolumab (3 m/kg) and pembrolizumab (200 mg) were administered in 70.4% and 53% of patients, respectively. The analysis of risk factor of thyroid-related adverse reaction did not show statistically significant differences (Cox regression). Conclusion Thyroid-related adverse events are common in patients treated with PD-1 inhibitors and hypothyroidism is the most frequent adverse reaction. Routine TFTs monitoring is strongly recommended to evaluate thyroid function in real-world clinical practice.

Objective: PD-1 inhibitors have demonstrated improved health outcomes in cancer patients. PD-1 inhibitors are well-tolerated and associated with immune-related adverse events. The objectives of this study are to analyze use patterns of PD-1 inhibitors in patients with cancer and to investigate the incidence of thyroid-related adverse reactions in patients treated with PD-1 inhibitors. Methods: The study included patients who had been administered PD-1 inhibitors (either nivolumab or pembrolizumab) at the Samsung Medical Center between October 1, 2016 and June 30, 2017. Data was collected from electronic medical records and tested using Mann-Whitney tests and Chi-Square tests for statistical significance. Associations between PD-1 inhibitors and incidence of adverse events were tested using Cox regression for age, gender, BMI, ECOG PS and medication. Results: Two hundred fifteen patients were identified as eligible for analyses. Thyroid-related adverse events occurred in 20% of patients (n=43). Thyroid function tests (TFTs) was performed in 109 patients (50.7%). Positive results of PD-L1 testing were found in 53.2% of the 94 patients who had the test. Approved doses of nivolumab (3 m/kg) and pembrolizumab (200 mg) were administered in 70.4% and 53% of patients, respectively. The analysis of risk factor of thyroid-related adverse reaction did not show statistically significant differences (Cox regression). Conclusion Thyroid-related adverse events are common in patients treated with PD-1 inhibitors and hypothyroidism is the most frequent adverse reaction. Routine TFTs monitoring is strongly recommended to evaluate thyroid function in real-world clinical practice.

PURPOSE: The purpose of this study was to develop a scale to measure person-centered critical care nursing and verify its reliability and validity. METHODS: A total of 38 preliminary items on person-centered critical care nursing were selected using content validity analysis of and expert opinion on 72 candidate items derived through literature review and qualitative interviews. We conducted a questionnaire survey with 477 nurses who worked in intensive care units. The collected data were analyzed using exploratory factor analysis (EFA) and confirmative factor analysis (CFA) with SPSS and AMOS 24.0 program. RESULTS: EFA was performed with principal axis factor analysis and Varimax rotation. The 15 items in 4 factors that accounted for 50.8% of the total variance were identified by deleting the items that were not meet the condition that the commonality should be .30 or more and the factor loading over .40. We named the factors as compassion, individuality, respect, and comfort, respectively. The correlation coefficient between this scale and the Caring Perception Scale was r=.57 (p < .001), which determined concurrent validity. The item-total correlation values ranged from .39 to .63, and the internal consistency for the scale was Cronbach's α=.84. CONCLUSION: The reliability and validity of the 15 item person-centered critical care nursing scale were verified. It is expected that the use of this scale would expand person-centered care in critical care nursing.
Critical Care Nursing* ; Critical Care* ; Empathy ; Expert Testimony ; Factor Analysis, Statistical ; Individuality ; Intensive Care Units ; Patient-Centered Care ; Reproducibility of Results

BACKGROUND: Tumor-infiltrating lymphocytes, which form a part of the host immune system, affect the development and progression of cancer. This study investigated whether subsets of lymphocytes reflecting host-tumor immunologic interactions are related to the prognosis of patients with acute myeloid leukemia (AML). METHODS: Lymphocyte subsets in the peripheral blood of 88 patients who were newly diagnosed with AML were analyzed by quantitative flow cytometry. The relationships of lymphocyte subsets with AML subtypes, genetic risk, and clinical courses were analyzed. RESULTS: The percentages of T and NK cells differed between patients with acute promyelocytic leukemia (APL) and those with AML with myelodysplasia-related changes. In non-APL, a high proportion of NK cells (>16.6%) was associated with a higher rate of death before remission (P=0.0438), whereas a low proportion of NK cells (≤9.4%) was associated with higher rates of adverse genetic abnormalities (P=0.0244) and relapse (P=0.0567). A multivariate analysis showed that the lymphocyte subsets were not independent predictors of survival. CONCLUSION: Lymphocyte subsets at diagnosis differ between patients with different specific subtypes of AML. A low proportion of NK cells is associated with adverse genetic abnormalities, whereas a high proportion is related to death before remission. However, the proportion of NK cells may not show independent correlations with survival.
Diagnosis ; Flow Cytometry ; Humans ; Immune System ; Killer Cells, Natural ; Leukemia, Myeloid, Acute* ; Leukemia, Promyelocytic, Acute ; Lymphocyte Subsets* ; Lymphocytes* ; Lymphocytes, Tumor-Infiltrating ; Multivariate Analysis ; Prognosis ; Recurrence

OBJECTIVE: To assess the cross-sectional area (CSA) of the muscles for investigating the occurrence of asymmetry of the paraspinal (multifidus and erector spinae) and psoas muscles and its relation to the chronicity of unilateral lumbar radiculopathy using magnetic resonance imaging (MRI). METHODS: This retrospective study was conducted between January 2012 to December 2014. Sixty one patients with unilateral L5 radiculopathy were enrolled: 30 patients had a symptom duration less than 3 months (group A) and 31 patients had a symptom duration of 3 months or more (group B). Axial MRI measured the CSA of the paraspinal and psoas muscles at the middle between the lower margin of the upper vertebra and upper margin of the lower vertebra, and obtained the relative CSA (rCSA) which is the ratio of the CSA of muscles to that of the lower margin of L4 vertebra. RESULTS: There were no differences in the demographics between the two groups. In group B, rCSA of the erector spinae at the L4–5 level, and that of multifidus at the L4–5 and L5–S1 levels, were significantly smaller on the involved side as compared with the uninvolved side. In contrast, no significant muscle asymmetry was observed in group A. The rCSA of the psoas was not affected in either group. CONCLUSION: The atrophy of the multifidus and erector spinae ipsilateral to the lumbar radiculopathy was observed only in patients suffering from unilateral radiculopathy for 3 months or more.
Atrophy* ; Demography ; Humans ; Magnetic Resonance Imaging ; Muscles ; Muscular Atrophy ; Paraspinal Muscles* ; Psoas Muscles ; Radiculopathy* ; Retrospective Studies ; Spine