1.Comparison of Population Attributable Fractions of Cancer Incidence and Mortality Linked to Excess Body Weight in Korea from 2015 to 2030
Youjin HONG ; Jihye AN ; Jeehi JUNG ; Hyeon Sook LEE ; Soseul SUNG ; Sungji MOON ; Inah KIM ; Jung Eun LEE ; Aesun SHIN ; Sun Ha JEE ; Sun-Seog KWEON ; Min-Ho SHIN ; Sangmin PARK ; Seung-Ho RYU ; Sun Young YANG ; Seung Ho CHOI ; Jeongseon KIM ; Sang-Wook YI ; Yoon-Jung CHOI ; Sangjun LEE ; Woojin LIM ; Kyungsik KIM ; Sohee PARK ; Jeong-Soo IM ; Hong Gwan SEO ; Kwang-Pil KO ; Sue K. PARK
Endocrinology and Metabolism 2024;39(6):921-931
		                        		
		                        			 Background:
		                        			The increasing rate of excess body weight (EBW) in the global population has led to growing health concerns, including cancer-related EBW. We aimed to estimate the population attributable fraction (PAF) of cancer incidence and deaths linked to EBW in Korean individuals from 2015 to 2030 and to compare its value with various body mass index cutoffs. 
		                        		
		                        			Methods:
		                        			Levin’s formula was used to calculate the PAF; the prevalence rates were computed using the Korean National Health and Nutrition Examination Survey data, while the relative risks of specific cancers related to EBW were estimated based on the results of Korean cohort studies. To account for the 15-year latency period when estimating the PAF in 2020, the prevalence rates from 2015 and attributable cases or deaths from 2020 were used. 
		                        		
		                        			Results:
		                        			The PAF attributed to EBW was similar for both cancer incidence and deaths using either the World Health Organization (WHO) Asian-Pacific region standard or a modified Asian standard, with the WHO standard yielding the lowest values. In the Korean population, the PAFs of EBW for cancer incidence were 2.96% in men and 3.61% in women, while those for cancer deaths were 0.67% in men and 3.06% in women in 2020. Additionally, PAFs showed a gradual increase in both sexes until 2030. 
		                        		
		                        			Conclusion
		                        			The EBW continues to have a significant impact on cancer incidence and deaths in Korea. Effective prevention strategies targeting the reduction of this modifiable risk factor can substantially decrease the cancer burden. 
		                        		
		                        		
		                        		
		                        	
2.Dental Implant Fractures: A Report of 43 Implant Fixtures in 33 Patients
Journal of implantology and applied sciences 2024;28(1):1-9
		                        		
		                        			 Purpose:
		                        			 Implant-supported  restorations  have  become  the  standard  treatment  for  edentulous  patients. However, several complications have been reported, including implant-fixture fracture.  This study aimed to determine the risk factors for dental implant-fixture fracture by evaluating 43  fractured implant fixtures in 33 patients.  
		                        		
		                        			Materials and Methods:
		                        			This study included patients referred from local clinics owing to implant  fracture  between  2006  and  2023.  The  implant  type  and  location,  method  for  removal,  and  risk  factors for implant fracture were investigated. 
		                        		
		                        			Results:
		                        			This study included 22 men and 11 women (mean age, 60.8 years; range, 33–82 years).  Implant fracture was twice as common in men than in women. Fractures were more common in  fixtures  with  internal  connections  rather  than  in  those  with  external  connections.  More  implant  fractures were observed in patients with single implants than in those with multiple implants. 
		                        		
		                        			Conclusion
		                        			 Since  the  only  solution  to  implant  fracture  is  removal,  regular  follow-up  and  biomechanical and biological considerations to reduce dental implant fracture are necessary.  
		                        		
		                        		
		                        		
		                        	
3.Comparison of Population Attributable Fractions of Cancer Incidence and Mortality Linked to Excess Body Weight in Korea from 2015 to 2030
Youjin HONG ; Jihye AN ; Jeehi JUNG ; Hyeon Sook LEE ; Soseul SUNG ; Sungji MOON ; Inah KIM ; Jung Eun LEE ; Aesun SHIN ; Sun Ha JEE ; Sun-Seog KWEON ; Min-Ho SHIN ; Sangmin PARK ; Seung-Ho RYU ; Sun Young YANG ; Seung Ho CHOI ; Jeongseon KIM ; Sang-Wook YI ; Yoon-Jung CHOI ; Sangjun LEE ; Woojin LIM ; Kyungsik KIM ; Sohee PARK ; Jeong-Soo IM ; Hong Gwan SEO ; Kwang-Pil KO ; Sue K. PARK
Endocrinology and Metabolism 2024;39(6):921-931
		                        		
		                        			 Background:
		                        			The increasing rate of excess body weight (EBW) in the global population has led to growing health concerns, including cancer-related EBW. We aimed to estimate the population attributable fraction (PAF) of cancer incidence and deaths linked to EBW in Korean individuals from 2015 to 2030 and to compare its value with various body mass index cutoffs. 
		                        		
		                        			Methods:
		                        			Levin’s formula was used to calculate the PAF; the prevalence rates were computed using the Korean National Health and Nutrition Examination Survey data, while the relative risks of specific cancers related to EBW were estimated based on the results of Korean cohort studies. To account for the 15-year latency period when estimating the PAF in 2020, the prevalence rates from 2015 and attributable cases or deaths from 2020 were used. 
		                        		
		                        			Results:
		                        			The PAF attributed to EBW was similar for both cancer incidence and deaths using either the World Health Organization (WHO) Asian-Pacific region standard or a modified Asian standard, with the WHO standard yielding the lowest values. In the Korean population, the PAFs of EBW for cancer incidence were 2.96% in men and 3.61% in women, while those for cancer deaths were 0.67% in men and 3.06% in women in 2020. Additionally, PAFs showed a gradual increase in both sexes until 2030. 
		                        		
		                        			Conclusion
		                        			The EBW continues to have a significant impact on cancer incidence and deaths in Korea. Effective prevention strategies targeting the reduction of this modifiable risk factor can substantially decrease the cancer burden. 
		                        		
		                        		
		                        		
		                        	
4.Comparison of Population Attributable Fractions of Cancer Incidence and Mortality Linked to Excess Body Weight in Korea from 2015 to 2030
Youjin HONG ; Jihye AN ; Jeehi JUNG ; Hyeon Sook LEE ; Soseul SUNG ; Sungji MOON ; Inah KIM ; Jung Eun LEE ; Aesun SHIN ; Sun Ha JEE ; Sun-Seog KWEON ; Min-Ho SHIN ; Sangmin PARK ; Seung-Ho RYU ; Sun Young YANG ; Seung Ho CHOI ; Jeongseon KIM ; Sang-Wook YI ; Yoon-Jung CHOI ; Sangjun LEE ; Woojin LIM ; Kyungsik KIM ; Sohee PARK ; Jeong-Soo IM ; Hong Gwan SEO ; Kwang-Pil KO ; Sue K. PARK
Endocrinology and Metabolism 2024;39(6):921-931
		                        		
		                        			 Background:
		                        			The increasing rate of excess body weight (EBW) in the global population has led to growing health concerns, including cancer-related EBW. We aimed to estimate the population attributable fraction (PAF) of cancer incidence and deaths linked to EBW in Korean individuals from 2015 to 2030 and to compare its value with various body mass index cutoffs. 
		                        		
		                        			Methods:
		                        			Levin’s formula was used to calculate the PAF; the prevalence rates were computed using the Korean National Health and Nutrition Examination Survey data, while the relative risks of specific cancers related to EBW were estimated based on the results of Korean cohort studies. To account for the 15-year latency period when estimating the PAF in 2020, the prevalence rates from 2015 and attributable cases or deaths from 2020 were used. 
		                        		
		                        			Results:
		                        			The PAF attributed to EBW was similar for both cancer incidence and deaths using either the World Health Organization (WHO) Asian-Pacific region standard or a modified Asian standard, with the WHO standard yielding the lowest values. In the Korean population, the PAFs of EBW for cancer incidence were 2.96% in men and 3.61% in women, while those for cancer deaths were 0.67% in men and 3.06% in women in 2020. Additionally, PAFs showed a gradual increase in both sexes until 2030. 
		                        		
		                        			Conclusion
		                        			The EBW continues to have a significant impact on cancer incidence and deaths in Korea. Effective prevention strategies targeting the reduction of this modifiable risk factor can substantially decrease the cancer burden. 
		                        		
		                        		
		                        		
		                        	
5.Dental Implant Fractures: A Report of 43 Implant Fixtures in 33 Patients
Journal of implantology and applied sciences 2024;28(1):1-9
		                        		
		                        			 Purpose:
		                        			 Implant-supported  restorations  have  become  the  standard  treatment  for  edentulous  patients. However, several complications have been reported, including implant-fixture fracture.  This study aimed to determine the risk factors for dental implant-fixture fracture by evaluating 43  fractured implant fixtures in 33 patients.  
		                        		
		                        			Materials and Methods:
		                        			This study included patients referred from local clinics owing to implant  fracture  between  2006  and  2023.  The  implant  type  and  location,  method  for  removal,  and  risk  factors for implant fracture were investigated. 
		                        		
		                        			Results:
		                        			This study included 22 men and 11 women (mean age, 60.8 years; range, 33–82 years).  Implant fracture was twice as common in men than in women. Fractures were more common in  fixtures  with  internal  connections  rather  than  in  those  with  external  connections.  More  implant  fractures were observed in patients with single implants than in those with multiple implants. 
		                        		
		                        			Conclusion
		                        			 Since  the  only  solution  to  implant  fracture  is  removal,  regular  follow-up  and  biomechanical and biological considerations to reduce dental implant fracture are necessary.  
		                        		
		                        		
		                        		
		                        	
6.Comparison of Population Attributable Fractions of Cancer Incidence and Mortality Linked to Excess Body Weight in Korea from 2015 to 2030
Youjin HONG ; Jihye AN ; Jeehi JUNG ; Hyeon Sook LEE ; Soseul SUNG ; Sungji MOON ; Inah KIM ; Jung Eun LEE ; Aesun SHIN ; Sun Ha JEE ; Sun-Seog KWEON ; Min-Ho SHIN ; Sangmin PARK ; Seung-Ho RYU ; Sun Young YANG ; Seung Ho CHOI ; Jeongseon KIM ; Sang-Wook YI ; Yoon-Jung CHOI ; Sangjun LEE ; Woojin LIM ; Kyungsik KIM ; Sohee PARK ; Jeong-Soo IM ; Hong Gwan SEO ; Kwang-Pil KO ; Sue K. PARK
Endocrinology and Metabolism 2024;39(6):921-931
		                        		
		                        			 Background:
		                        			The increasing rate of excess body weight (EBW) in the global population has led to growing health concerns, including cancer-related EBW. We aimed to estimate the population attributable fraction (PAF) of cancer incidence and deaths linked to EBW in Korean individuals from 2015 to 2030 and to compare its value with various body mass index cutoffs. 
		                        		
		                        			Methods:
		                        			Levin’s formula was used to calculate the PAF; the prevalence rates were computed using the Korean National Health and Nutrition Examination Survey data, while the relative risks of specific cancers related to EBW were estimated based on the results of Korean cohort studies. To account for the 15-year latency period when estimating the PAF in 2020, the prevalence rates from 2015 and attributable cases or deaths from 2020 were used. 
		                        		
		                        			Results:
		                        			The PAF attributed to EBW was similar for both cancer incidence and deaths using either the World Health Organization (WHO) Asian-Pacific region standard or a modified Asian standard, with the WHO standard yielding the lowest values. In the Korean population, the PAFs of EBW for cancer incidence were 2.96% in men and 3.61% in women, while those for cancer deaths were 0.67% in men and 3.06% in women in 2020. Additionally, PAFs showed a gradual increase in both sexes until 2030. 
		                        		
		                        			Conclusion
		                        			The EBW continues to have a significant impact on cancer incidence and deaths in Korea. Effective prevention strategies targeting the reduction of this modifiable risk factor can substantially decrease the cancer burden. 
		                        		
		                        		
		                        		
		                        	
7.Dental Implant Fractures: A Report of 43 Implant Fixtures in 33 Patients
Journal of implantology and applied sciences 2024;28(1):1-9
		                        		
		                        			 Purpose:
		                        			 Implant-supported  restorations  have  become  the  standard  treatment  for  edentulous  patients. However, several complications have been reported, including implant-fixture fracture.  This study aimed to determine the risk factors for dental implant-fixture fracture by evaluating 43  fractured implant fixtures in 33 patients.  
		                        		
		                        			Materials and Methods:
		                        			This study included patients referred from local clinics owing to implant  fracture  between  2006  and  2023.  The  implant  type  and  location,  method  for  removal,  and  risk  factors for implant fracture were investigated. 
		                        		
		                        			Results:
		                        			This study included 22 men and 11 women (mean age, 60.8 years; range, 33–82 years).  Implant fracture was twice as common in men than in women. Fractures were more common in  fixtures  with  internal  connections  rather  than  in  those  with  external  connections.  More  implant  fractures were observed in patients with single implants than in those with multiple implants. 
		                        		
		                        			Conclusion
		                        			 Since  the  only  solution  to  implant  fracture  is  removal,  regular  follow-up  and  biomechanical and biological considerations to reduce dental implant fracture are necessary.  
		                        		
		                        		
		                        		
		                        	
8.Fusion Length Requiring Spinopelvic Fixation in Lumbosacral Fusion with Anterior Column Support at L5–S1: Assessment of Fusion Status Using Computed Tomography
Sung Cheol PARK ; Sangjun PARK ; Do-Hyung LEE ; Jinew SEO ; Jae Hyuk YANG ; Min-Seok KANG ; Yunjin NAM ; Seung Woo SUH
Clinics in Orthopedic Surgery 2024;16(1):86-94
		                        		
		                        			 Background:
		                        			The lumbosacral (LS) junction has a higher nonunion rate than other lumbar segments, especially in long-level fusion. Nonunion at L5–S1 would result in low back pain, spinal imbalance, and poor surgical outcomes. Although anterior column support at L5–S1 has been recommended to prevent nonunion in long-level LS fusion, fusion length requiring additional spinopelvic fixation (SPF) in LS fusion with anterior column support at L5–S1 has not been evaluated thoroughly. This study aimed to determine the number of fused levels requiring SPF in LS fusion with anterior column support at L5–S1 by assessing the interbody fusion status using computed tomography (CT) depending on the fusion length. 
		                        		
		                        			Methods:
		                        			Patients who underwent instrumented LS fusion with L5–S1 interbody fusion without additional augmentation and CT > 1 year postoperatively were included. The fusion rates were assessed based on the number of fused segments. Patients were divided into two groups depending on the L5–S1 interbody fusion status: those with union vs. those with nonunion. Binary logistic regression analyses were performed to identify risk factors for LS junctional nonunion. 
		                        		
		                        			Results:
		                        			Fusion rates of L5–S1 interbody fusion were 94.9%, 90.3%, 80.0%, 50.0%, 52.6%, and 43.5% for fusion of 1, 2, 3, 4, 5, and ≥ 6 levels, respectively. The number of spinal levels fused ≥ 4 (p < 0.001), low preoperative bone mineral density (BMD; adjusted odds ratio [aOR], 0.667; p = 0.035), and postoperative pelvic incidence (PI) – lumbar lordosis (LL) mismatch (aOR, 1.034; p = 0.040) were identified as significant risk factors for nonunion of L5–S1 interbody fusion according to the multivariate logistic regression analysis. 
		                        		
		                        			Conclusions
		                        			Exhibiting ≥ 4 fused spinal levels, low preoperative BMD, and large postoperative PI–LL mismatch were identified as independent risk factors for nonunion of anterior column support at L5–S1 in LS fusion without additional fixation. Therefore, SPF should be considered in LS fusion extending to or above L2 to prevent LS junctional nonunion. 
		                        		
		                        		
		                        		
		                        	
9.A Comparison of Green, Delta, and Monte Carlo Methods to Select an Optimal Approach for Calculating the 95% Confidence Interval of the Population-attributable Fraction: Guidance for Epidemiological Research
Sangjun LEE ; Sungji MOON ; Kyungsik KIM ; Soseul SUNG ; Youjin HONG ; Woojin LIM ; Sue K. PARK
Journal of Preventive Medicine and Public Health 2024;57(5):499-507
		                        		
		                        			 Objectives:
		                        			This study aimed to compare the Delta, Greenland, and Monte Carlo methods for estimating 95% confidence intervals (CIs) of the population-attributable fraction (PAF). The objectives were to identify the optimal method and to determine the influence of primary parameters on PAF calculations. 
		                        		
		                        			Methods:
		                        			A dataset was simulated using hypothetical values for primary parameters (population, relative risk [RR], prevalence, and variance of the beta estimator ) involved in PAF calculations. Three methods (Delta, Greenland, and Monte Carlo) were used to estimate the 95% CIs of the PAFs. Perturbation analysis was performed to assess the sensitivity of the PAF to changes in these parameters. An R Shiny application, the “GDM-PAF CI Explorer,” was developed to facilitate the analysis and visualization of these computations. 
		                        		
		                        			Results:
		                        			No significant differences were observed among the 3 methods when both the RR and p-value were low. The Delta method performed well under conditions of low prevalence or minimal RR, while Greenland’s method was effective in scenarios with high prevalence. Meanwhile, the Monte Carlo method calculated 95% CIs of PAFs that were stable overall, though it required intensive computational resources. In a novel approach that utilized perturbation for sensitivity analysis, was identified as the most influential parameter in the estimation of CIs. 
		                        		
		                        			Conclusions
		                        			This study emphasizes the necessity of a careful approach for comparing 95% CI estimation methods for PAFs and selecting the method that best suits the context. It provides practical guidelines to researchers to increase the reliability and accuracy of epidemiological studies. 
		                        		
		                        		
		                        		
		                        	
10.A Case of Subcutaneous Emphysema and Pneumomediastinum After Balloon Eustachian Tuboplasty
Chan Ho YOON ; Sae Hwan PARK ; In Beom PARK ; Sangjun KIM
Korean Journal of Otolaryngology - Head and Neck Surgery 2024;67(3):166-170
		                        		
		                        			
		                        			 The Eustachian tube is a passage that connects the middle ear to the nasopharynx and regulates the pressure within the middle ear. If there is persistent inflammation in the mucosa due to infection or allergic reactions, the opening of the Eustachian tube may not function properly, leading to obstructive Eustachian tube dysfunction. If symptoms persist even after three months of conservative treatment, balloon Eustachian tuboplasty may be considered. Although rare, severe complications such as subcutaneous emphysema, pneumomediastinum, and pneumothorax can occur, but there have been no reported cases of such complications in the Republic of Korea so far. Here, we present a case of a 52-year-old male who developed subcutaneous emphysema and pneumomediastinum after undergoing balloon Eustachian tuboplasty and discuss prevention and treatment for possible complications following the procedure. 
		                        		
		                        		
		                        		
		                        	
            
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