Objective: To explore the characteristics and influencing factors of unintentional burns among left-behind children in rural areas of northern Guizhou, from the perspective of parents and children, to formulate strategies to prevent children from burns. Methods: A total of 508 left-behind children were recruited by using a multistage cluster sampling method, and 196 left-behind children’s families were also investigated with a self-designed questionnaire.The relative factors of burns were analyzed by unconditional logistic regression and multiple regression analysis. Results: The report rate of burns among left-behind children was 12.20%(62/508). Left-behind girls were a risk factor for burns(OR=1.81). The time of employment >5 years and the higher of the score of burn-related knowledge were the protective factors(OR=0.23, 0.38)(P<0.05). Only 64.80% of left-behind children’s main guardians had a burns-related knowledge score of 60 or more. The age of their main guardian, the number of minor children, and whether understand of unintentional injury were the influencing factors of burns score. Conclusion The report rate of burns among left-behind children in rural areas in northern Guizhou is still high; parents/guardians have a low cognition level of burns. The knowledge of burns should be strengthened and left-behind children should be cared to reduce the incidence of burns.