Objective To establish and validate a predictive model for acute posterior circulation infarction in patients with vertebral artery dysplasia based on ultrasound and clinical data.Methods A total of 347 patients with an ultrasonic diagnosis of vertebral artery dysplasia who were admitted to our hospital from March 2017 to December 2023 were enrolled as subjects.A multivariate logistic regression analysis was used to identify the risk factors for acute posterior circulation infarction in patients with vertebral artery dysplasia,and R software was used to establish a nomogram predictive model for acute posterior circulation infarction in patients with vertebral artery dysplasia.Then the model was assessed and validated.Results Among the 347 patients with vertebral artery dysplasia,50 patients developed acute posterior circulation infarction,resulting in an incidence rate of 14.4%.The multivariate logical regression analysis showed that the nomogram model based on the predictive factors of hypertension,diabetes,hyperhomocysteinemia,embryonal posterior cerebral artery,and vertebral artery dominance had an area under the ROC curve of 0.772(95%confidence interval:0.700?0.844),with a Brier score of 0.105.Conclusion The nomogram model based on the predictive factors of hypertension,diabetes,hyperhomocysteinemia,embryonal posterior cerebral artery,and vertebral artery dominance has a relatively high value in predicting acute posterior circulation infarction in patients with vertebral artery dysplasia.

Aim To investigate the therapeutic effect of Jiangtang Wan (JTW) on mioe with diabetic kidney disease (DKD) and to explore its potential moiecuiar mechanism on ameliorating renal injury and fibrosis. Methods C57BL/6 mice were randomly divided into four groups: the control group, the model group, JTW group (1250 mg • kg

OBJECTIVE:To optimize the extraction technology of garlic oil. METHODS:Using extraction rate of garlic oil as index,based on single factor test,Box-Behnken response surface method was used to optimize conditions of steam distillation method for the extraction of garlic as fermentation time,solid to liquid ratio,fermentation temperature and the verification test were made for the optimized technology. RESULTS:The optimal extraction technology was as follows as fermentation time of 4.5 h,solid to liquid ratio of 1:7,fermentation temperature of 55 ℃. The average extraction rate of garlic oil in verification test was 0.32%(RSD=1.43%,n=3);the relative error between the measured value and predicted value was 0.06%. CONCLUSIONS:Box-Behnken response surface method is simple,reasonable and feasible to optimize the extraction technology of garlic oil,which can provide a scientific basis for industrial production.