Objective:To explore the application effect of empowerment psychological nursing model combined with hope theory in patients with intracranial aneurysms.Methods:A total of 90 patients with intracranial aneurysm who were admitted to Ruian People's Hospital in Zhejiang Province from August 2015 to January 2019 were randomly selected and they were divided into the observation group and the control group according to the random number table method, with 45 patients in each group. The control group received routine nursing, while the observation group received nursing based on empowerment psychological nursing model combined with hope theory. Before the intervention and 2 months after the intervention, Herth Hope Inventory (HHI) , Self-Perceived Burden Scale (SPBS) , Psychological Capital Questionnaire (PCQ) and Short Form 36-item Health Survey (SF-36) were used to evaluate the hope level, self-perceived burden, psychological capital and quality of life of patients in two groups. The Glasgow Outcome Scale (GOS) was used to compare the prognosis of the two groups after 2 months of intervention.Results:After 2 months of intervention, the HHI, PCQ, and SF-36 scores of the observation group were higher than those before the intervention, and higher than those in the control group, and the differences were statistically significant ( P<0.05) . SPBS scores of patients in both groups were lower than those before intervention, and the score in the observation group was (27.28±5.06) , lower than (32.64±4.12) in the control group. The differences were statistically significant ( P<0.05) . After 2 months of intervention, the excellent and good rate of GOS classification was 91.11% (41/45) in the observation group and 80.00% (36/45) in the control group, but the difference between the two groups was not statistically significant ( P>0.05) . Conclusions:Empowerment psychological nursing model combined with hope theory can effectively improve the hope level and psychological capital of patients amd reduce the self-perceived burden, thus improving the quality of life.