Objective To investigate the health status of employees in Guangdong gas stations and analyze the factors of occupational hazards. Methods According to the records of the provincial comprehensive information system, and the division of administrative regions, a random sampling method was used to detect 22 street gas stations in the town of Xixiang, Baoan District, Shenzhen, with 335 related employees included. The hazardous factors of volatile chemical compositions were analyzed, and the results of occupational health examinations of gas station workers were evaluated. Results The occupational hazards in the volatile organic components of each oil product at 22 gas stations were analyzed, and the results showed that they all met the national standards. The occupational health status was evaluated on all employees in the gas stations in this survey. Most of them did not find any occupational hazards, but the health status of the staff in the duty room was better than that of the staff beside the tanker. Conclusion The gas station workers were at the general occupational hazard risk, but occupational protection also needs to be strengthened. Regular inspection of oil and gas recovery devices is required to improve the airtightness. Regular occupational training should be conducted to further standardize vocational operation.