Objective The clinical fall prevention information system is developed and its effect is verified,pro-viding references for the prevention of clinical falls through information technology.Methods Based on the screen-ing-assessment-intervention-evaluation process recommended by the toolkit,a clinical fall prevention information sys-tem was constructed through the steps of team formation and group discussion.The system includes 2 modules of fall prevention clinical practice and fall adverse event management,and 5 basic functions of fall risk assessment,structured risk point screening,personalized intervention measures,evaluation report and intervention prescription,and adverse event reporting.From September to December 2021,the system was tested in 6 departments with a high incidence of falls in a tertiary A hospital in Chongqing,and the application effect of the system was verified from 5 aspects:friendliness of the system interface,professional guidance,improvement of patient participation,reduction of fall incidence and injury rate.Results 68.9％of nurses thought that the system was user-friendly;82.7％thought that the system was professional and instructive;75.3％thought that the system could improve patients'participation in fall prevention.After trial of the system,the incidence of falls and injury decreased,but the statistical difference was not obvious(P＞0.05).Conclusion This system realized multi-team cooperation to jointly pay attention to pa-tients'falls,and it was well recognized by nurses in terms of professional guidance and improving patients'partici-pation in fall prevention.At the same time,due to the short trial and verification time,narrow scope and small sample size of this system,its fall prevention effect needs to be further promoted and verified.