1.Clinical characteristics of human adenovirus infection in hospitalized children with acute respiratory infection in Beijing.
Fang Ming WANG ; Chuan Yu YANG ; Yuan QIAN ; Fang LI ; Li GU ; Dong Mei CHEN ; Yu SUN ; Ru Nan ZHU ; Fang WANG ; Qi GUO ; Yu Tong ZHOU ; Ri DE ; Ling CAO ; Dong QU ; Lin Qing ZHAO
Chinese Journal of Pediatrics 2022;60(1):30-35
Objective: To compare the clinical characteristics of different types of human adenovirus (HAdV) infection in hospitalized children with acute respiratory infection in Beijing, and to clarify the clinical necessity of adenovirus typing. Methods: In a cross-sectional study, 9 022 respiratory tract specimens collected from hospitalized children with acute respiratory infection from November 2017 to October 2019 in Affiliated Children's Hospital, Capital Institute of Pediatrics were screened for HAdV by direct immunofluorescence (DFA) and (or) nucleic acid detection. Then the Penton base, Hexon and Fiber gene of HAdV were amplified from HAdV positive specimens to confirm their HAdV types by phylogenetic tree construction. Clinical data such as laboratory results and imaging data were analyzed for children with predominate type HAdV infection using t, U, or χ2 test. Results: There were 392 cases (4.34%) positive for HAdV among 9 022 specimens from hospitalized children with acute respiratory infection. Among those 205 cases who were successfully typed, 131 were male and 74 were female, age of 22.6 (6.7, 52.5) months,102 cases (49.76%) were positive for HAdV-3 and 86 cases (41.95%), HAdV-7, respectively, while 17 cases were confirmed as HAdV-1, 2, 4, 6, 14 or 21. In comparison of clinical characteristics between the predominate HAdV type 7 and 3 infection, significant differences were shown in proportions of children with wheezing (10 cases (11.63%) vs. 25 cases (24.51%)), white blood cell count >15 ×109/L (4 cases (4.65%) vs.14 cases (13.73%)), white blood cell count <5×109/L (26 cases (30.23%) vs.11 cases (10.78%)), procalcitonin level>0.5 mg/L (43 cases (50.00%) vs. 29 cases (28.43%)), multilobar infiltration (45 cases (52.33%) vs.38 cases (37.25%)), pleural effusion (23 cases (26.74%) vs. 10 cases (9.80%)), and severe adenovirus pneumonia (7 cases (8.14%) vs. 2 cases (1.96%)) with χ²=5.11, 4.44, 11.16, 9.19, 4.30, 9.25, 3.91 and P=0.024, 0.035, 0.001, 0.002, 0.038, 0.002, 0.048, respectively, and also in length of hospital stay (11 (8, 15) vs. 7 (5, 13) d, Z=3.73, P<0.001). Conclusions: HAdV-3 and 7 were the predominate types of HAdV infection in hospitalized children with acute respiratory tract infection in Beijing. Compared with HAdV-3 infection, HAdV-7 infection caused more obvious inflammatory reaction, more severe pulmonary symptoms, longer length of hospital stay, suggesting the clinical necessity of further typing of HAdVs.
Adenovirus Infections, Human/epidemiology*
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Adenoviruses, Human/genetics*
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Beijing/epidemiology*
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Child
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Child, Hospitalized
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Cross-Sectional Studies
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Female
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Humans
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Infant
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Male
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Phylogeny
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Respiratory Tract Infections/epidemiology*
3.Could upfront temozolomide chemotherapy postpone the need for radiotherapy in young patients with high-risk low-grade gliomas?
Ze-Yang LI ; Shi-Wen YUAN ; Yan-Yan SONG ; N U Farrukh HAMEED ; Hong CHEN ; Dong-Xiao ZHUANG ; Jun-Feng LU ; Fang-Yuan GONG ; Abudumijit AIBAIDULA ; Zhi-Feng SHI ; Shuai WU ; Qi-Hao GUO ; Jin-Song WU
Chinese Medical Journal 2021;134(11):1356-1358
4.Phenolic glycosides from the stems of Homalium stenophyllum.
Shou-Yuan WU ; Meng BAI ; Qi ZHOU ; Xu-Hua NONG ; Guang-Ying CHEN ; Si-Yu ZHAO ; Chang-Ri HAN ; Xiao-Ping SONG
Chinese Journal of Natural Medicines (English Ed.) 2021;19(3):225-230
The phytochemical investigation of the stems of Homalium stenophyllum afforded seven new phenolic glycosides (1-5 and 8-9) and two known compounds (6 and 7). Their structures were elucidated by comprehensive analyses of NMR spectroscopic, mass spectrometric data and chemical hydrolysis. Additionally, their anti-inflammatory activities against the NO production in LPS-induced macrophages were evaluated.
5.Cloning and Expression Patterns of LmC3H1 Gene in Lonicera macranthoides and Its Correlation with Chlorogenic Acid Content
Ya CHEN ; An-qi WANG ; Cong LIU ; Yu-qing LONG ; Xia LIU ; Juan ZENG ; Can LI ; Xiang-dan LIU ; Ri-bao ZHOU
Chinese Journal of Experimental Traditional Medical Formulae 2020;26(9):167-175
Objective::To clone
6.Clinical observation of heat-sensitive moxibustion treatment for coronavirus disease 2019.
Xian-Bao HUANG ; Ding-Yi XIE ; Qi QIU ; Yang SHEN ; Lin JIAO ; Qiao-Lin LI ; Ri-Xin CHEN
Chinese Acupuncture & Moxibustion 2020;40(6):576-580
OBJECTIVE:
To observe clinical effect of heat-sensitive moxibustion on coronavirus disease 2019 (COVID-19) and to discusses the effective moxibustion treatment program.
METHODS:
A total of 42 patients with COVID-19 (general type) were treated with heat-sensitive moxibustion at the acupoint area of Shenque (CV 8) and Tianshu (ST 25). The treatment was conducted under the standards of heat-sensitive moxibustion manipulation, which were "locating acupoint by feeling, moxibustion by differentiate sensation, dosage varies individually, ending after sufficient dosage". The incidence of after first heat-sensitive moxibustion, the reduction of negative emotions, the improvement of chest distress and impaired appetite, and the active acceptance rate of moxibustion before and after treatment were observed.
RESULTS:
① The rate of heat-sensitive moxibustion for 20 min、40 min、1 h were respectively 52.4% (22/42), 90.5% (38/42), 100.0% (42/42). ② The incidences of feeling relaxed and comfortable immediately after the first, second, and third heat-sensitive moxibustion were 61.9% (26/42), 73.8% (31/42), and 92.9% (39/42), which were higher than 42.9% (18/42) before heat-sensitive moxibustion treatment (<0.05). ③ The incidences of chest distress after the first, second, and third heat-sensitive moxibustion were 23.8% (10/42), 16.7% (7/42), and 9.5% (4/42), which were lower than 50.0% (21/42) before heat-sensitive moxibustion treatment (<0.05); the incidences of impaired appetite after the first, second, and third heat-sensitive moxibustion were 26.2% (11/42), 19.0% (8/42), 9.5% (4/42), which were lower than 57.1% (24/42) before heat-sensitive moxibustion treatment (<0.05). ④ After the first treatment, the active acceptance rate of patients for heat-sensitive moxibustion was 100.0% (42/42), which was higher than 11.9% (5/42) before heat-sensitive moxibustion (<0.05).
CONCLUSION
The heat-sensitive moxibustion can effectively reduce the negative emotions and improve the symptoms of chest distress and impaired appetite with COVID-19. It is generally accepted by patients, and worthy of popularization and application in clinical treatment.
Acupuncture Points
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Betacoronavirus
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Coronavirus Infections
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therapy
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Hot Temperature
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Humans
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Moxibustion
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Pandemics
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Pneumonia, Viral
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therapy
7.Professor 's academic idea of "pain in joint and disorder in tendon region of meridian" and its clinical application for knee arthralgia.
Lin JIAO ; Yan-Qi CHEN ; Zhen-Hai CHI ; Ri-Xin CHEN
Chinese Acupuncture & Moxibustion 2020;40(4):419-422
Professor -'s academic idea of "pain in joint and disorder in tendon region of meridian" was explored in this paper. According to the particular characteristics of the occurrence and development of the disease, knee arthralgia is divided into 4 stages, named tendon spasm, tendon blockage, tendon contraction and tendon atrophy. It is proposed that "tendon disorder results in bone disorder", implying the relationship between the disorders of tendon and bone. It is pointed that insufficiency occurs throughout knee arthralgia. "The tendon disorder should be treated at the first-line procedure for the bone disorder, and the tendon softening benefits the recovery of knee joints". The treatment principle includes "removing obstruction from meridian, eliminating pathogen, warming up and softening tendon". In clinical application, the heat-sensitive moxibustion is predominated. The various regimens are developed align with the pathogenesis characteristics of the disease at different stages.
Acupuncture Therapy
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Arthralgia
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therapy
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Humans
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Knee Joint
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physiopathology
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Meridians
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Moxibustion
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Pain
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Tendons
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physiopathology
8.Technical elements and clinical application of umbilical refining of heat-sensitive moxibustion.
Bo ZHANG ; Yan-Qi CHEN ; Chong-Xiu ZHOU ; Ri-Xin CHEN
Chinese Acupuncture & Moxibustion 2020;40(9):965-967
Under the guidance of the theory and technique of arrival of of heat-sensitive moxibustion, the technical elements of umbilical refining of moxibustion proposed in by were analyzed. It is believed that the parameters of moxibustion temperature and time are the key points. The standard of "quantitative moxa" is established to achieve the appropriate moxibustion temperature and moxibustion time. The umbilical refining of heat-sensitive moxibustion is established to reappear the magic effect of 's umbilical refining of moxibustion. The umbilical refining of heat-sensitive moxibustion is recommended for stomachache, diarrhea, constipation, dysmenorrhea, impotence, etc. with significant curative effect.
9.Application of professor 's academic thought " is often insufficient, but is often surplus" in heat-sensitive moxibustion for tumor rehabilitation.
Xian-Bao HUANG ; Yan-Qi CHEN ; Ding-Yi XIE ; Ri-Xin CHEN
Chinese Acupuncture & Moxibustion 2020;40(1):79-83
Professor has explored the causes of the characteristics of TCM syndromes in modern disease spectrum and pointed out that the TCM syndromes are generally characterized by " is often insufficient, but is often surplus". Based on the clinical experience and the understanding of TCM classics and ancient literature on tumor, professor has proposed that TCM syndromes of patients with advanced tumor are also generally characterized by " is often insufficient, but is often surplus". The heat-sensitive moxibustion has the functions of warming and nourishing eliminating dampness, warming meridians and dispersing cold, activating blood circulation and clearing collaterals, therefore tumor patients with deficiency syndrome (-deficiency, deficiency), cold syndrome, dampness syndrome, phlegm syndrome and blood-stasis syndrome belonging to the indications of heat-sensitive moxibustion. The heat-sensitive moxibustion has unique advantages in treating spleen-stomach dysfunction after chemotherapy and radiotherapy, bone marrow suppression after chemotherapy and radiotherapy, cancerous deficiency, cancerous pain, pleural effusion, ascites, constipation, which has important clinical value in improving the quality of life and prolonging the life time for patients with advanced tumors.
Hot Temperature
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Humans
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Medicine, Chinese Traditional
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Moxibustion
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Neoplasms
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therapy
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Quality of Life
10.Professor -'s academic thought and clinical application of "no allergy without any deficiency".
Jun XIONG ; Yan-Qi CHEN ; Ri-Xin CHEN
Chinese Acupuncture & Moxibustion 2020;40(2):199-202
The academic thought of professor - on "no allergy without any deficiency" was explored. Theory and the clinical application were elaborated on allergic diseases treated with heat-sensitive moxibustion. It is believed that the critical pathogenesis of allergic diseases is deficiency, particularly the deficiency of the lung, the spleen and the kidney. The invasion of exogenous factors or the disturbance of the retained pathogens in the body may induce allergy. Regarding the therapeutic method, the warming method is applicable for the deficiency and the heat-sensitization counteracts allergy. The sensitized points are detected in accordance with the two-step location method and they are stimulated with the suspended moxibustion. The feeling of heat-sensitive moxibustion is a sign of activation of endogenous regulatory function in the human body. It is a kind of external therapy for the internal disorders, directly acting on the pathogenesis, strengthening the antipathogenic and removing the allergic factors. This therapy is a new endogenous anti-allergic approach.

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