A 20-month-old male infant with multiorgan dysfunction after Epstein-Barr virus (EBV) infection developed Reye's syndrome. He also suffered from acute liver failure, life-threatening cerebral edema, severe disseminated intravascular coagulation (DIC), and myocardial involvement. EBV infection aggravated the progress of Reye's syndrome, leading to death despite full supportive and symptomatic therapy. This critical case suggested that pediatricians should pay attention to multiorgan involvement of severe EBV infection.
Epstein-Barr Virus Infections/complications* ; Fatal Outcome ; Herpesvirus 4, Human/physiology* ; Humans ; Infant ; Male ; Multiple Organ Failure/complications* ; Reye Syndrome/virology*