1.Gene Therapy for Bone Tissue Engineering.
Young Dong KIM ; Prasad POFALI ; Tae Eun PARK ; Bijay SINGH ; Kihyun CHO ; Sushila MAHARJAN ; Prajakta DANDEKAR ; Ratnesh JAIN ; Yun Jaie CHOI ; Rohidas AROTE ; Chong Su CHO
Tissue Engineering and Regenerative Medicine 2016;13(2):111-125
Gene therapy holds a great promise and has been extensively investigated to improve bone formation and regeneration therapies in bone tissue engineering. A variety of osteogenic genes can be delivered by combining different vectors (viral or non-viral), scaffolds and delivery methodologies. Ex vivo & in vivo gene enhanced tissue engineering approaches have led to successful osteogenic differentiation and bone formation. In this article, we review recent advances of gene therapy-based bone tissue engineering discussing strengths and weaknesses of various strategies as well as general overview of gene therapy.
Bone and Bones*
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Bone Morphogenetic Proteins
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Genetic Therapy*
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Osteogenesis
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Regeneration
;
Tissue Engineering
Result Analysis
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