OBJECTIVE: Detection and significance of CXCL8, IL-10 in serum and tissue of the patients' with OSHAS. METHOD: All subjects take serum CXCL8 and IL-10 levels were determined by ELISA. All subjects take the same position of the soft palate tissues in the operation. CXCL8 and IL-10 in the tissue expression was measured by immune histochemistry. RESULT: (1) Serum CXCL8 levels in OSHAS is higher than that in the control group (P < 0.05). (2) Serum IL-10 levels in OSHAS is lower than that in the control group (P < 0.05). (3) Tissues CXCL8 expression was correlated with serum CXCL8 (r = 0.474, P < 0.05). (4) Tissues IL-10 expression wasn't any correlated with serum IL-10. (5) Tissues IL-10 expression was correlated with tissues CXCL8 (r = 0.482, P < 0.05). CONCLUSION OSAHS may be a disease associated with inflammation, and closely relate with CXCL8 and IL-10.
Adult ; Case-Control Studies ; Female ; Humans ; Interleukin-10 ; blood ; metabolism ; Interleukin-8 ; blood ; metabolism ; Male ; Middle Aged ; Sleep Apnea, Obstructive ; blood ; metabolism

OBJECTIVE: To evaluate the prospective effect of applying midline partial glossectomy with Uvulopalatopharyngoplasty in the treatment of OSAHS. METHOD: The data of 40 patients with OSAHS operated with midline partial glossectomy with UPPP were analyzed. RESULT: The follow-up polysomnography (6-month follow-up) revealed that the mean apnea and hypopnea index decreased from 62.39+/-21.68 to 18.60+/-5.01 (P<0.01), and the mean minimal oxygen saturation (SaO2) increased from 64.40%+/-14.96% to 88.39%+/-9.21% (P<0.01). In general, 29 patients were with excellent curative effect, 8 with good effect, and 3 with bad effect. Total effective rate was 92.5%. CONCLUSION The study confirms that the same-stage midline partial glossectomy with UPPP for OSAHS is a safe and effective procedure.
Adult ; Female ; Glossectomy ; methods ; Humans ; Male ; Middle Aged ; Palate, Soft ; surgery ; Pharynx ; surgery ; Sleep Apnea, Obstructive ; surgery ; Treatment Outcome ; Uvula ; surgery