This article investigates the collaborative management of metabolic dysfunction-associated fatty liver disease （MAFLD） and chronic kidney disease （CKD）. As major public health issues worldwide， MAFLD and CKD are closely related in terms of epidemiology， pathogenesis， and management strategies， and however， there are still many challenges in the multidisciplinary collaborative management of the two diseases. This article systematically elaborates on the epidemiology of MAFLD and CKD， summarizes their common risk factors such as metabolic disorder， genetic susceptibility， and active metabolites， and reviews the mutual screening strategies and combined management models based on noninvasive imaging， serum markers， FIB-4 score， and liver stiffness measurement. In addition， this article summarizes the advances in the application of lifestyle intervention and new drugs （such as GLP-1 receptor agonists and SGLT-2 inhibitors） and emphasizes the importance of multidisciplinary collaboration in improving the prognosis of patients. Due to the close association between MAFLD and CKD， their joint management is crucial， and therefore， it is necessary to establish a multidisciplinary collaboration mechanism and implement the measures of precise screening， comprehensive treatment， and long-term monitoring， so as to improve the prognosis of patients and reduce the risk of complications. Finally， this article proposes that in the future， more effective combined treatment regimens should be explored to expand the clinical options for the co-management of the liver and the kidney.

[Purpose]To analyze the death causes of malignant tumor among residents in Qinghai Province from 2017 to 2021.[Methods]The death cause surveillance data and resident popula-tion data in Qinghai Province from 2017 to 2021 were collected.The crude mortality rate(CMR),age-standardized mortality rate by Chinese standard population(ASMRC),composition of death,rank of cause of death were analyzed by Excel 2021 and SPSS 21.0 software.[Results]From 2017 to 2021,the CMR of all cancers of residents in Qinghai Province was 89.64/105,the ASMRC was 103.17/105.The cancer mortality rate of males was higher than that of females.The mortality rate of stomach cancer ranked the first,and followed by liver cancer,lung cancer,esophageal cancer and colorectal cancer.The top 10 cancer deaths accounted for 83.73％of all cancer deaths.Mortality increased with age,there were significant differences in cancer mortality rate among age groups.The cancer mortality rate was highest in pastoral areas,followed by rural areas and urban areas.The ranking of cancer deaths varied in different areas.Stomach cancer was the leading cause of death in rural and pastoral areas,while lung cancer was the leading cause in ur-ban areas.[Conclusion]The mortality rates of stomach,liver and lung cancers are high in Qinghai Province.The targeted and comprehensive prevention and control strategies should be taken ac-cording to the epidemic characteristics of malignant tumors in different regions and populations.