Objective:To explore the risk factors of changes in the condition of patients waiting for emergency pre-examination and triage, so as to provide a feasible basis for medical and nursing staff to effectively assess changes in the condition of emergency patients.Methods:From October to December 2019, 244 patients waiting for pre-examination and triage in the Emergency Department of a ClassⅢ Grade A in Beijing were selected as the research object. Patients with changes in their condition during treatment were regarded as the observation group ( n=120) , and patients without changes in their condition were regarded as the control group ( n=124) . Univariate analysis and multivariate logistic regression analysis were used to identify the risk factors for changes in the condition of waiting patients in the Emergency Department. Results:The differences in gender, age, systolic blood pressure, diastolic blood pressure, heart rate, blood oxygen saturation, disease type, main symptoms and triage level between the two groups of patients waiting for emergency pre-examination and triage were statistically significant ( P<0.05) . Binary Logistic regression analysis showed that male, age ≥60 years, abnormal heart rate, low blood oxygen saturation, and low triage level had a high rate of disease change ( P<0.05) . Conclusions:The risk factors for changes in the condition of emergency pre-examination and triage patients are mainly reflected in five aspects, namely gender, age, heart rate, blood oxygen saturation and triage level. During the pre-examination and triage, nurses should not only make timely and correct responses according to the triage level, but also pay full attention to patients with high-risk factors in order to timely find patients with changing conditions and provide emergency treatment.