Objective To investigate the clinical effect and value of meropenem in the treatment of purulent meningitis .Methods 88 patients with purulent meningitis in our hospital from January 2009 to December 2012 were randomly divided into observation group and control group, according to the proportion of 1:1, the subjects were randomly divided into observation group and control group, with 44 cases in each group.The control group was treated with ceftriaxone and amoxicillin sulbactam.The observation group was treated with meropenem for injection.Comparison of the two groups of children with temperature decline time, the time of disappearance of intracranial pressure, brain marrow fluid returned to normal time, clinical efficacy and bacteriological efficacy and adverse reactions.Results After treatment,The cure rate of the observation group was 68.18%, the total effective rate was 95.45%, higher than the control group 45.45%, 65.91%, the difference was statistically significant ( P<0.05 ) .Bacterial clearance rate of the observation group was 65.91%, higher than the control group 43.18%, the difference was statistically significant (P<0.05).The unclear rate 2.27%, replacement rate 2.27%, and the re-infection rate 2.27% of the observation group were significantly lower than those of the control group 18.18%, 9.09%, 9.09%, the difference was statistically significant (P<0.05).The temperature decline time, the time of disappearance of intracranial pressure and CSF recovery time of the observation group were significantly shorter than the control group, the difference was statistically significant (P<0.05). Gastrointestinal symptoms, neurological symptoms and skin symptoms and other adverse reaction rate of 4.55% of the observation group compared with the control group 4.55%, the difference was not statistically significant.Conclusion Meropenem treatment of purulent meningitis in children with significant effect, safe and reliable, is purulent meningitis in children is an ideal choice, it is worth further expanding the sample to be studied for the rationalization of the drug to provide more reference basis for clinical services .