Purpose: Prostate-specific membrane antigen (PSMA) Positron emission tomography/magnetic resonance imaging (PET/ MRI) surpasses conventional MRI (cMRI) in prostate cancer (PCa) evaluation. Our objective is to evaluate correlation of quantitative parameters in PCa using Fluorine-18 (F-18) PSMA-1007 PET/MRI and their potential for predicting metastases. Methods: This retrospective study included 51 PCa patients. Apparent diffusion coefficient (ADC), maximum standardized uptake value (SUVmax), PSMA total lesion uptake (PSMA-TLU), and PSMA total volume (PSMA-TV) were calculated in primary tumor. Correlation of ADC with other parameters was analyzed. Receiver Operating Characteristic curve analysis was conducted to determine optimal cut-off values for predicting metastases. Results: ADC inversely correlated with SUVmax, PSMA-TLU, and PSMA-TV (p < 0.0001, < 0.0001, 0.0050, respectively).Lower ADC was associated with metastatic disease (p < 0.001). SUVmax, PSMA-TLU, PSMA-TV, SUVmax/ADC, PSMATLU/ADC, and PSMA-TV/ADC were higher in patients with metastases (p = 0.033 to < 0.001). PSMA-TLU/ADC and PSMA-TV/ADC best predicted metastases (sensitivity: 73.91% and 82.61%; specificity: 89.29% and 71.43%). PSMA-TLU, PSMA-TV, PSMA-TLU/ADC, and PSMA-TV/ADC were higher in patients with lymph node metastasis (p = 0.001 to 0.005).PSMA-TLU/ADC and PSMA-TV/ADC best predicted lymph node metastasis (sensitivity: 77.78% and 100%; specificity:89.29% and 71.43%). SUVmax and SUVmax/ADC were higher in bone metastasis cases (p = 0.045), but their predictive value for bone metastasis was limited (Area under the curve (AUC): 0.634 and 0.652). Conclusion F-18 PSMA-1007 PET/MRI may improve diagnostic accuracy for primary PCa lesions by utilizing the inverse relationship between ADC and other parameters. Moreover, a strong correlation between such parameters and presence of metastasis holds prognostic value of this modality.

Purpose: Prostate-specific membrane antigen (PSMA) Positron emission tomography/magnetic resonance imaging (PET/ MRI) surpasses conventional MRI (cMRI) in prostate cancer (PCa) evaluation. Our objective is to evaluate correlation of quantitative parameters in PCa using Fluorine-18 (F-18) PSMA-1007 PET/MRI and their potential for predicting metastases. Methods: This retrospective study included 51 PCa patients. Apparent diffusion coefficient (ADC), maximum standardized uptake value (SUVmax), PSMA total lesion uptake (PSMA-TLU), and PSMA total volume (PSMA-TV) were calculated in primary tumor. Correlation of ADC with other parameters was analyzed. Receiver Operating Characteristic curve analysis was conducted to determine optimal cut-off values for predicting metastases. Results: ADC inversely correlated with SUVmax, PSMA-TLU, and PSMA-TV (p < 0.0001, < 0.0001, 0.0050, respectively).Lower ADC was associated with metastatic disease (p < 0.001). SUVmax, PSMA-TLU, PSMA-TV, SUVmax/ADC, PSMATLU/ADC, and PSMA-TV/ADC were higher in patients with metastases (p = 0.033 to < 0.001). PSMA-TLU/ADC and PSMA-TV/ADC best predicted metastases (sensitivity: 73.91% and 82.61%; specificity: 89.29% and 71.43%). PSMA-TLU, PSMA-TV, PSMA-TLU/ADC, and PSMA-TV/ADC were higher in patients with lymph node metastasis (p = 0.001 to 0.005).PSMA-TLU/ADC and PSMA-TV/ADC best predicted lymph node metastasis (sensitivity: 77.78% and 100%; specificity:89.29% and 71.43%). SUVmax and SUVmax/ADC were higher in bone metastasis cases (p = 0.045), but their predictive value for bone metastasis was limited (Area under the curve (AUC): 0.634 and 0.652). Conclusion F-18 PSMA-1007 PET/MRI may improve diagnostic accuracy for primary PCa lesions by utilizing the inverse relationship between ADC and other parameters. Moreover, a strong correlation between such parameters and presence of metastasis holds prognostic value of this modality.

Purpose: Prostate-specific membrane antigen (PSMA) Positron emission tomography/magnetic resonance imaging (PET/ MRI) surpasses conventional MRI (cMRI) in prostate cancer (PCa) evaluation. Our objective is to evaluate correlation of quantitative parameters in PCa using Fluorine-18 (F-18) PSMA-1007 PET/MRI and their potential for predicting metastases. Methods: This retrospective study included 51 PCa patients. Apparent diffusion coefficient (ADC), maximum standardized uptake value (SUVmax), PSMA total lesion uptake (PSMA-TLU), and PSMA total volume (PSMA-TV) were calculated in primary tumor. Correlation of ADC with other parameters was analyzed. Receiver Operating Characteristic curve analysis was conducted to determine optimal cut-off values for predicting metastases. Results: ADC inversely correlated with SUVmax, PSMA-TLU, and PSMA-TV (p < 0.0001, < 0.0001, 0.0050, respectively).Lower ADC was associated with metastatic disease (p < 0.001). SUVmax, PSMA-TLU, PSMA-TV, SUVmax/ADC, PSMATLU/ADC, and PSMA-TV/ADC were higher in patients with metastases (p = 0.033 to < 0.001). PSMA-TLU/ADC and PSMA-TV/ADC best predicted metastases (sensitivity: 73.91% and 82.61%; specificity: 89.29% and 71.43%). PSMA-TLU, PSMA-TV, PSMA-TLU/ADC, and PSMA-TV/ADC were higher in patients with lymph node metastasis (p = 0.001 to 0.005).PSMA-TLU/ADC and PSMA-TV/ADC best predicted lymph node metastasis (sensitivity: 77.78% and 100%; specificity:89.29% and 71.43%). SUVmax and SUVmax/ADC were higher in bone metastasis cases (p = 0.045), but their predictive value for bone metastasis was limited (Area under the curve (AUC): 0.634 and 0.652). Conclusion F-18 PSMA-1007 PET/MRI may improve diagnostic accuracy for primary PCa lesions by utilizing the inverse relationship between ADC and other parameters. Moreover, a strong correlation between such parameters and presence of metastasis holds prognostic value of this modality.

Purpose: Prostate-specific membrane antigen (PSMA) Positron emission tomography/magnetic resonance imaging (PET/ MRI) surpasses conventional MRI (cMRI) in prostate cancer (PCa) evaluation. Our objective is to evaluate correlation of quantitative parameters in PCa using Fluorine-18 (F-18) PSMA-1007 PET/MRI and their potential for predicting metastases. Methods: This retrospective study included 51 PCa patients. Apparent diffusion coefficient (ADC), maximum standardized uptake value (SUVmax), PSMA total lesion uptake (PSMA-TLU), and PSMA total volume (PSMA-TV) were calculated in primary tumor. Correlation of ADC with other parameters was analyzed. Receiver Operating Characteristic curve analysis was conducted to determine optimal cut-off values for predicting metastases. Results: ADC inversely correlated with SUVmax, PSMA-TLU, and PSMA-TV (p < 0.0001, < 0.0001, 0.0050, respectively).Lower ADC was associated with metastatic disease (p < 0.001). SUVmax, PSMA-TLU, PSMA-TV, SUVmax/ADC, PSMATLU/ADC, and PSMA-TV/ADC were higher in patients with metastases (p = 0.033 to < 0.001). PSMA-TLU/ADC and PSMA-TV/ADC best predicted metastases (sensitivity: 73.91% and 82.61%; specificity: 89.29% and 71.43%). PSMA-TLU, PSMA-TV, PSMA-TLU/ADC, and PSMA-TV/ADC were higher in patients with lymph node metastasis (p = 0.001 to 0.005).PSMA-TLU/ADC and PSMA-TV/ADC best predicted lymph node metastasis (sensitivity: 77.78% and 100%; specificity:89.29% and 71.43%). SUVmax and SUVmax/ADC were higher in bone metastasis cases (p = 0.045), but their predictive value for bone metastasis was limited (Area under the curve (AUC): 0.634 and 0.652). Conclusion F-18 PSMA-1007 PET/MRI may improve diagnostic accuracy for primary PCa lesions by utilizing the inverse relationship between ADC and other parameters. Moreover, a strong correlation between such parameters and presence of metastasis holds prognostic value of this modality.

Purpose: Prostate-specific membrane antigen (PSMA) Positron emission tomography/magnetic resonance imaging (PET/ MRI) surpasses conventional MRI (cMRI) in prostate cancer (PCa) evaluation. Our objective is to evaluate correlation of quantitative parameters in PCa using Fluorine-18 (F-18) PSMA-1007 PET/MRI and their potential for predicting metastases. Methods: This retrospective study included 51 PCa patients. Apparent diffusion coefficient (ADC), maximum standardized uptake value (SUVmax), PSMA total lesion uptake (PSMA-TLU), and PSMA total volume (PSMA-TV) were calculated in primary tumor. Correlation of ADC with other parameters was analyzed. Receiver Operating Characteristic curve analysis was conducted to determine optimal cut-off values for predicting metastases. Results: ADC inversely correlated with SUVmax, PSMA-TLU, and PSMA-TV (p < 0.0001, < 0.0001, 0.0050, respectively).Lower ADC was associated with metastatic disease (p < 0.001). SUVmax, PSMA-TLU, PSMA-TV, SUVmax/ADC, PSMATLU/ADC, and PSMA-TV/ADC were higher in patients with metastases (p = 0.033 to < 0.001). PSMA-TLU/ADC and PSMA-TV/ADC best predicted metastases (sensitivity: 73.91% and 82.61%; specificity: 89.29% and 71.43%). PSMA-TLU, PSMA-TV, PSMA-TLU/ADC, and PSMA-TV/ADC were higher in patients with lymph node metastasis (p = 0.001 to 0.005).PSMA-TLU/ADC and PSMA-TV/ADC best predicted lymph node metastasis (sensitivity: 77.78% and 100%; specificity:89.29% and 71.43%). SUVmax and SUVmax/ADC were higher in bone metastasis cases (p = 0.045), but their predictive value for bone metastasis was limited (Area under the curve (AUC): 0.634 and 0.652). Conclusion F-18 PSMA-1007 PET/MRI may improve diagnostic accuracy for primary PCa lesions by utilizing the inverse relationship between ADC and other parameters. Moreover, a strong correlation between such parameters and presence of metastasis holds prognostic value of this modality.

A patient with intrahepatic cholangiocarcinoma who underwent hepatic resection with completed neoadjuvant chemotherapy presented with increased CEA levels. Previous whole abdominal and chest CT scan revealed no evidence of local recurrence or metastasis. 68Ga-FAPI-46 PET showed significantly higher tumor-to-background contrast of recurrent tumor and nodal metastasis, which were undetectable in the FDG PET or conventional CT scan. These findings changed patient management. Larger studies with histopathological correlation and comparisons with other imaging modalities are required to validate the diagnostic performance. Moreover, a cystic lesion with FAPI uptake at the neck to the proximal body of the pancreas without FDG uptake is also incidentally noted. Differential diagnoses include sided branch IPMN and serous cystadenoma.