1.Antibiotic prescription patterns among pediatric patients with pneumonia in primary care – A retrospective cohort study.
Jami Aliyah D. SALLIMAN ; Leonila D. DANS ; Sally Jane VELASCO-ARO ; Arianna Maever LORECHE-AMIT ; Cara Lois T. GALINGANA ; Mia P. REY ; Josephine T. SANCHEZ ; Nanette B. SUNDIANG ; Herbert S. ZABALA ; Antonio L. DANS
Acta Medica Philippina 2025;59(2):55-61
BACKGROUND AND OBJECTIVES
The etiology of pneumonia in the pediatric population varies by age group. Among patients one month to 59 months old, viral pathogens are the most common cause of lower respiratory infections. The study aims to determine the frequency distribution of antibiotic prescription among patients one month to 59 months old and to determine the adherence of primary care facilities to local guidelines with recommended antibiotics.
METHODSA descriptive retrospective study using electronic medical records was conducted at two primary care sites. Patients aged 1 month to 59 months old seeking consult via telemedicine or face-to-face diagnosed with community acquired pneumonia from April 2019-March 2020 in the rural facility and May 2019-April 2020 in the remote facility were included in the study. The primary outcome was to determine the patterns of antibiotic use in pneumonia in remote and rural areas and adherence to the recommended antibiotics by the 2016 Philippine Academy of Pediatric Pulmonologists pediatric community-acquired pneumonia clinical practice guidelines (CPG).
RESULTSThere were 30 pediatric patients diagnosed with pneumonia in the rural facility and 213 in the remote facility. Of these patients with pneumonia, 96.7% and 94.8% were prescribed antibiotics in the rural and remote sites, respectively. The most commonly prescribed antibiotic in the rural facility was co-amoxiclav (26.7%), while amoxicillin (51.6%) was the most common in the remote facility. Adherence to the CPG in the rural site was lower at 23.3% (n=8/30) compared to the remote site which was 55.9% (n=119/213).
CONCLUSIONPrimary care physicians prescribed antibiotics in over 90% of the time upon the diagnosis of pneumonia in children aged one month to 59 months old, despite viral pneumonia being the more common in primary care setting. Adherence to recommended antibiotics was higher in the remote setting than in the rural setting. Use of EMR to monitor quality of care can improve patient outcomes and safety, pointing out the importance of improving the quality of documentation in the study sites.
Human ; Infant Newborn: First 28 Days After Birth ; Infant: 1-23 Months ; Child Preschool: 2-5 Yrs Old ; Pediatrics ; Pneumonia ; Primary Health Care
2.Factors associated with adverse outcomes among SARS-CoV-2 positive children in a Tertiary Government COVID-19 Referral Hospital in the Philippines
Mark Jason DC. Milan ; Al Joseph R. Molina ; Anna Lisa T. Ong-Lim ; Ma. Esterlita V. Uy ; Herbert G. Uy
Acta Medica Philippina 2024;58(7):73-89
Background and Objective:
Pediatric COVID-19 epidemiology and factors associated with adverse outcomes-mortality, need for invasive mechanical ventilation, and ICU admission, are largely unstudied. We described the clinicodemographic characteristics of Filipino pediatric COVID-19 patients and determined the factors associated with adverse outcomes.
Methods:
This is a retrospective cohort study of 180 hospitalized SARS-CoV-2-confirmed cases 0-18 years old
from April 2020 to August 2021 in a tertiary COVID-19 referral hospital in Manila, National Capital Region. Crude associations were determined using chi-squared or Fisher’s exact tests; and medians were compared using the Mann-Whitney test. Factors predictive of mortality were determined using Cox proportional hazards regression analysis. The survivor functions were depicted in graphs.
Results:
About 41.67% had mild disease, 58.33% were males, 39.4% aged 0-4 years, and 69.44% had at least one comorbidity. About 9.44% died (adjusted 9.2 persons per 1000 patient-days, 95% CI 5.5%-15.2%), 17.78% needed invasive mechanical ventilation, and 20% needed ICU admission. Independently, severe-critical COVID-19 (HRc 11.51, 95% CI 3.23, 41.06), retractions (HRc 10.30, 95% CI 3.27, 32.47), alar flaring (HRc 4.39, 95% CI 1.53, 12.58), cyanosis (HRc 4.39, 95% CI 1.72, 14.11), difficulty of breathing (HRc 7.99, 95% CI 2.25, 28.71), poor suck/appetite (HRc 4.46, 95% CI 1.59, 12.40), ferritin (HRc 1.01, 95% CI 1.00, 1.01), IL-6 (HRc 1.01, 95% CI 1.00, 1.01), aPTT (HRc 1.05, 95% CI 1.01, 1.10), IVIg (HRc 4.00, 95% CI 1.07, 14.92) and corticosteroid (HRc 6.01, 95% CI 2.04, 17.67) were significant hazards for mortality. In adjusted Cox analysis, only retractions (HRa 34.96, 95% CI 3.36, 363.79), seizure (HRa 9.98, 95% CI 1.76, 56.55), and corticosteroids (HRa 8.21, 95% CI 1.12, 60.38) were significantly associated with mortality while alar flaring appeared to be protective (HRa 0.10, 95% CI 0.01, 0.95). Several clinical characteristics were consistently associated with adverse outcomes.
Conclusions
Majority of hospitalized pediatric COVID-19 patients were very young, males, had mild
disease, and had at least one comorbidity. Mortality, invasive mechanical ventilation, and ICU admission were relatively low. Except for alar flaring which appeared to be protective, retractions, seizure, and use of
corticosteroids were associated with adverse outcomes.
COVID-19
;
Epidemiology
;
Philippines
;
Child
;
Pediatrics
3.Antibiotic prescription patterns among pediatric patients with pneumonia in primary care – A retrospective cohort study
Jami Aliyah D. Salliman ; Leonila D. Dans ; Sally Jane Velasco-Aro ; Arianna Maever Loreche-Amit ; Cara Lois T. Galingana ; Mia P. Rey ; Josephine T. Sanchez ; Nanette B. Sundiang ; Herbert S. Zabala ; Antonio L. Dans
Acta Medica Philippina 2024;58(Early Access 2024):1-7
Background and Objectives:
The etiology of pneumonia in the pediatric population varies by age group. Among
patients one month to 59 months old, viral pathogens are the most common cause of lower respiratory infections. The study aims to determine the frequency distribution of antibiotic prescription among patients one month to 59 months old and to determine the adherence of primary care facilities to local guidelines with recommended antibiotics.
Methods:
A descriptive retrospective study using electronic medical records was conducted at two primary care sites. Patients aged 1 month to 59 months old seeking consult via telemedicine or face-to-face diagnosed with community acquired pneumonia from April 2019-March 2020 in the rural facility and May 2019-April 2020 in the remote facility were included in the study. The primary outcome was to determine the patterns of antibiotic use in pneumonia in remote and rural areas and adherence to the recommended antibiotics by the 2016 Philippine Academy of Pediatric Pulmonologists pediatric community-acquired pneumonia clinical practice guidelines (CPG).
Results:
There were 30 pediatric patients diagnosed with pneumonia in the rural facility and 213 in the remote
facility. Of these patients with pneumonia, 96.7% and 94.8% were prescribed antibiotics in the rural and remote sites, respectively. The most commonly prescribed antibiotic in the rural facility was co-amoxiclav (26.7%), while amoxicillin (51.6%) was the most common in the remote facility. Adherence to the CPG in the rural site was lower at 23.3% (n=8/30) compared to the remote site which was 55.9% (n=119/213).
Conclusion
Primary care physicians prescribed antibiotics in over 90% of the time upon the diagnosis of pneumonia in children aged one month to 59 months old, despite viral pneumonia being the more common in primary care setting. Adherence to recommended antibiotics was higher in the remote setting than in the rural setting. Use of EMR to monitor quality of care can improve patient outcomes and safety, pointing out the importance of improving the quality of documentation in the study sites.
Pediatrics
;
Pneumonia
;
Primary Health Care
4.Caregivers’ perceptions and willingness to utilize telerehabilitation for outpatient consultation and therapy for pediatric patients in a COVID-referral center in a developing country: A cross-sectional study
Julie Ann T. Dulawan ; Sharon D. Ignacio ; Cynthia D. Ang-Muñ ; oz ; Frances Ann B. Carlos ; Carl Froilan D. Leochico
Acta Medica Philippina 2024;58(20):20-28
BACKGROUND
During the COVID-19 pandemic, social isolation and quarantine measures set to control the spread of the infection paved for the increased utilization of virtual methods of consultation and follow-up. Telerehabilitation allows access to rehabilitation services despite distance and makes possible the continuation of rehabilitation services despite the lack of face-to-face interaction. This is difficult for pediatric patients who are dependent on their caregivers for understanding and making decisions regarding their health. Loss of continuity of rehabilitation services led to poorer outcomes in children with disabilities. Although advantageous for them, pediatric patients may not benefit from telerehabilitation if caregivers have negative perceptions of the process and are unwilling to utilize the service.
OBJECTIVESThis study determined caregivers’ perceptions and willingness to participate in telerehabilitation as a method of outpatient follow-up for pediatric patients admitted to a COVID-referral center in a developing country.
METHODSThe study utilized a descriptive cross-sectional design. Respondents were adults (≥19 years old) caring for pediatric patients admitted at non-COVID wards of the Philippine General Hospital and who were referred for rehabilitation services. A survey tool adapted from a previous study on willingness to utilize telemedicine among caregivers of pediatric patients was translated into the Filipino language and used in the study. A dataset from Excel was imported in STATA 16 (StataCorp, Texas, USA) and was exhaustively checked for completeness, accuracy, and consistency before analysis. The association between patient characteristics and willingness to utilize telerehabilitation for any app was determined using Pearson’s chi-squared test or Fisher’s exact test, as appropriate. The latter was used when more than 20% of the cells had an expected value of less than or equal to five. A P value of less than 0.05 was considered significant for all tests.
RESULTSOf 123 respondents, 92 (75%) reported willingness to utilize telerehabilitation for outpatient consultation and therapy using video calls or a customized telerehabilitation app when available. Among 31 (25%) respondents who were not willing or unsure of participation, the main reasons identified were preference for face-to-face, lack of financial resources/load, poor connectivity, and doubt about the effectiveness of telerehabilitation.Patients with younger age (Fisher’s exact test, P=0.023), low usage of video call service (Fisher’s exact test, P=0.020), and lack of available devices (Fisher’s exact test, P=0.015) significantly reduced willingness to utilize telerehabilitation. Caregiver age, sex, educational attainment, estimated monthly income, number of devices used, speed of internet connectivity, and technological behaviors did not show statistical significance in association with willingness to participate in telerehabilitation.Most caregivers recognized the usefulness of a service allowing transmission of health data to and from the hospital, consultation with a doctor in case of an emergency, sending of reminders for medical visits and therapy, and provision of a list of home exercises and nutritional recommendations. Telerehabilitation was perceived advantageous, but concerns regarding privacy, trust, lack of human contact, and technological difficulty were also present.
CONCLUSIONWith high levels of willingness among caregivers, telerehabilitation is a viable method of providing rehabilitation services for the continuation of management after inpatient admission among pediatric patients. Limitations in its utilization include technological issues including the lack of devices, low level of service use, and slow internet connectivity. Although well perceived as advantageous, there are concerns regarding loss of human contact, difficulty in using technological devices, and trust and privacy issues that may affect utilization.
Human ; Telerehabilitation ; Caregivers ; Pediatrics ; Children With Disability ; Disabled Children ; Covid-19 ; Developing Countries
5.Diagnostic accuracy of pneumonia panel multiplex RT-PCR assay for the detection of respiratory bacterial pathogens among pediatric patients admitted for pneumonia at a tertiary hospital in Manila, Philippines
Lalaine Victoria F. Improgo ; Carmina A. delos Reyes
Pediatric Infectious Disease Society of the Philippines Journal 2024;25(2):42-53
BACKGROUND
Pneumonia in children causes significant morbidity and mortality especially in those less than 5 years of age. Accuracy of multiplex diagnostic tests for rapid identification of microbial etiology is not well established. This study was undertaken to determine the diagnostic accuracy of a pneumonia panel multiplex RT-PCR assay in the detection of respiratory pathogens among pediatric patients with pneumonia.
METHODOLOGYThis retrospective analytic cross-sectional study included children less than 19 years old diagnosed with pneumonia between June 2022 to June 2023 with respiratory samples for bacterial culture and pneumonia panel multiplex RT PCR assay.
RESULTSA total of 211 pediatric patients were included in the study. Of these, 72% were diagnosed with community acquiredpneumonia, 95% of them had endotracheal aspirate specimens. Bacterial pathogens were detected in 131 patients (61%). Of the 172 patients who had positive detections, 51 (30%) had at least one antibiotic-resistant gene identified. There was moderate agreement between the two methods (72.51%, kappa = 0.4632). Pneumonia panel multiplex RT-PCR assay showed acceptable discriminative ability (0.74) with accuracy at 72.51% and high sensitivity (88.42%), but specificity was only 59.48%. Its useresulted to the escalation of antimicrobial therapy in 15% of patients.
The pneumonia panel multiplex RT PCR assay is a valid diagnostic aid in the detection of respiratory pathogens for children with pneumonia given its good discriminative ability, high accuracy, and sensitivity.
Pneumonia ; Pediatrics
6.Adherence of primary care providers to practice guidelines for common pediatric conditions in urban, rural, and remote sites in the Philippines: A cross-sectional study
Raezelle Nadine C. Ramoso ; Mara Isabel C. Moreno ; Leonila F. Dans ; Zharie P. Benzon ; Regine Ynez H. De Mesa ; Noleen Marie C. Fabian ; Cara Lois T. Galingana ; Carol Stephanie C. Tan-Lim ; Antonio Miguel L. Dans
Acta Medica Philippina 2024;58(21):20-29
BACKGROUND
Evaluation of primary care allows for identification of problems in the healthcare system, such as poor health outcomes, inappropriate health services, overuse of unnecessary resources, or underuse of recommended strategies. Assessment of adherence to existing clinical practice guidelines as quality indicators is critical for evaluating the effectiveness of primary care and shaping healthcare policies.
OBJECTIVESTo determine the adherence of primary care providers to existing practice guidelines for common pediatric concerns in remote, rural, and urban areas in the Philippines.
METHODSThis cross-sectional study included data from the electronic medical records (EMR) of patients aged 19 years and below who consulted at the three pilot sites of the Philippine Primary Care Studies (PPCS) from January to December 2019. Relevant demographic data and quality indicator measures (e.g., immunization history, adolescent smoking history, medication and supplement prescription) were extracted from the EMR by the PPCS data management team. Adherence to existing guidelines on pediatric history taking and management of common illnesses (e.g., diarrhea, upper respiratory tract infections, malnutrition) was evaluated.
RESULTSThis study included 8,724 pediatric patients seen across the three pilot sites from January to December 2019. Immunization history was taken in only 0.4% of pediatric patients. Smoking history was taken in only 6.8% of adolescent patients. Zinc was prescribed in only 40.1% of patients with diarrhea. No infants were prescribed with vitamin A, while iron was prescribed in only 2.5% of children and 3% of adolescent females. In contrast to the recommendations of existing guidelines, antibiotics were prescribed in 38.5% of patients with AGE and 62.5% of patients with viral URTI. Montelukast was prescribed as first-line asthma treatment in 4.7% of cases. Multivitamins were prescribed in 57.2% of all pediatric patients.
Overuse of inappropriate medications and underuse of appropriate interventions were observed in this study. There was low adherence to evaluation of pediatric immunization history, adolescent smoking history, zinc supplementation for diarrhea, and iron and vitamin A supplementation among identified vulnerable population groups. Over prescription of the following were observed: (1) antibiotics for acute gastroenteritis and probable viral URTI, (2) multivitamins for the general pediatric population, and (3) montelukast among newly diagnosed asthma patients.
Human ; Pediatrics ; Primary Health Care ; Electronic Medical Records ; Electronic Health Records
7.Sleep disturbances among 4- to 12-year-old Filipino children with drug resistant epilepsy in a pediatric tertiary hospital
The Philippine Children’s Medical Center Journal 2024;20(1):59-72
Objectives:
To perform a pilot study on the frequency of sleep-disturbance (Total sleep
Disturbance Score (TSD) of > 41) in children diagnosed with Drug Resistant Epilepsy aged 4 to 12
years, using the Children’s Sleep Habits Questionnaire (CSHQ).
Methodology:
The Children’s Sleep Habits Questionnaire (CSHQ) was used to screen for sleep disturbances among 73 patients aged 4 to 12 years old with drug-resistant epilepsy seen at the Seizure Clinic of Philippine Children’s Medical Center. Descriptive statistics were used to characterize sociodemographic variables, and sleep and epilepsy-related variables. Continuous data were presented as mean ± standard deviation (SD), and categorical data as frequencies (percentages).
Results:
Sleep disturbances were common and severe in children with drug-resistant epilepsy. Out of the seventy-three participants, 61 patients had a TSD score of greater than 41 (84%) and 12 (16%) had TSD scores below 41 with a mean CSHQ score of 58. The most frequently occurring sleep disturbances involve the domains of bedtime resistance (29%), night wakings (28%), and daytime sleepiness (23%). Meanwhile, the least frequently occurring sleep disturbances involve the domains of sleep disordered breathing (76%), parasomnias (65%), and sleep anxiety (56%).
Conclusion
Majority of the children with drug-resistant epilepsy are sleep disturbed exhibiting high TSD scores (>41) using the Children’s Sleep Habits Questionnaire. We recommend to actively evaluate and screen for sleep and behavioral problems concurrently in children with epilepsy.
Epilepsy
;
Pediatrics
8.State of maternal–fetal medicine in the Philippines
Philippine Journal of Obstetrics and Gynecology 2024;48(2):79-82
The practice of maternal–fetal medicine (MFM) in
the Philippines originated within the broader scope
of obstetrics and gynecology. The specialty started to
emerge to address the need for specialized care for
high‑risk pregnancies and the management of fetal
complications. Over the years, the development of
MFM as a distinct subspecialty has evolved through
advancements in medical technology, training programs,
and the increasing complexity of pregnancy management.
The Philippine Society of MFM (PSMFM), established
in 1996, is the primary organization representing MFM
specialists in the country. It is dedicated to advancing
the field through education, training, service, and
research. PSMFM provides its members a platform to
enhance their knowledge, improve their skills, foster
collaboration, and share expertise.
Perinatology
;
Pregnancy, High-Risk
10.Advancing pediatric care before birth.
Kun SUN ; Mark WALKER ; Yongjun ZHANG ; Tao DUAN ; Luming SUN ; Jun ZHANG
Frontiers of Medicine 2023;17(2):352-354


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