Background: In recent years, scientists have found that certain natural compounds have significant potential in cancer prevention and early-stage cancer treatment. Flavanones, a class of polyphenolic compounds found in plants, vegetables, seeds, fruit peels, and flowers, have been identified to possess anticancer, antioxidant, anti- inflammatory, and antibacterial bioactivities. Cancer has become a major global challenge in terms of both economic and public health concerns. Global statistics indicate that 22.8% of deaths are attributed to non-communicable diseases, and 16.8% are caused by cancer, accounting for one in four and one in six deaths, respectively. Aim : To investigate anticancer effects of Iris Tenuifolia-derived flavanone on cancer cell lines. Materials and Methods : The study was conducted at the Bio-Medical Research Institute of the Mongolian National Uni versity of Medical Sciences, investigating the effect of flavanones on cancer cell viability under in vitro conditions using the MTT assay. In the study, colon, liver, and lung cancer cells were cultured, stabilized, and used for the experiments. Colorectal cancer cells (MC38), liver cancer cells (HepG2), and lung cancer cells (A549) were revived, cultured, and stabilized for use in the experimental procedures. Statistical analysis of the results was performed using Microsoft Excel 2010, and graphs were generated using GraphPad Prism 8. Differences between groups were analyzed using Student’s t-test, and a p-value of <0.05 was considered statistically significant. Results : We treated MC38, HepG2, and A549 cancer cells with different concentrations of flavanone (2.5 µM, 5 µM, and 10 µM) for 24 to 48 hours to evaluate cell viability. Flavanone inhibited A549 cell viability by 2.5 μM-10%, 5 μM-25%, and 10 μM-38%, respectively. For HepG2 cells, flavanone treatment at concentrations of 5-10 µM reduced cell viability by 28–58%. No statistically significant effect on the viability of MC38 cells was observed following treatment with flavanone at concentrations ranging from 2.5 to 10 µM. Additionally, although MC38 inhibited cell viability in a dose-de pendent manner in cell cultures, it had a statistically significant effect at higher concentrations of 30-200 μM (p<0.01). Conclusion Flavanone inhibits the cancer cell viability in a dose and time dependent manner

Traditional drug Jonlon-5 have been widely used in the clinical practice for recent years in traditional medicine. The study was conducted on the experimental animal wistar rats by the carrageenan induced mice paw edema (Winter et al. 1962, Vogel, 2002) methods. We performed chemical and pharmacological investigation was based and implemented scientific research laboratory of Institute of Traditional Medicine and Technology. The Jonlon-5 significantly (P<0.05) inhibited carrageenan induced rat paw edema as compared to control group. TNF-α secretion was magnified by carrageenan injec¬tion (387.2 pg/ml). TNF-α secretion was reduced, com¬parable to carrageenan group, as a respond to extract administration. Administration of Jonlon-5 significantly reduced inflammatory mediator secretion TNF-α by 20.8%, IL-1 β – 41.7%, to be close to inhibition level of Indo¬methacin administration. Jonlon-5 significantly decreased (P<0.05) of serum malondialdehyde (MDA) 16.5% in animal model.

Background: The prescription of Shar gaa made from the Curcuma longa L., Tribulus terrestris L., Cortex Phellodendri L., Gardenia jasminoides L. By reviewing a lot of relative research papers and the pharmacological dictionaries, we summarized the conclusion that the efficiency components of the Shar gaa extract is effective to control the infection of bacteria and the fungi, to relieve skin inflammation and pain.Aim:We conducted the control experiment to discuss thecontrol effect of the Shar gaa extract to the fungi and the bacteria. Materials and methods:We carried out susceptibility test to fungus and bacterium using medicine dilution method and cup-plate method on the sand clan proof agar culture and nutrient agar culture. The fungi inhibition results show that the Shar gaa extract has the significant restrain effects to all of experimental fungi. It has the better effects to the Microsporum lanosum M.grpseum、T.rubrum、M. canis、C.albicans、Pityrosporum than the 20% Ethanol control group (P<0.05). Meanwhile, it has the same affects with the CAILE extract (P>0.05). In addition, the Shar gaa extract of high concentration has no significant difference with the one of the low concentration. This phenomenon demonstrated the truth that the Shar gaa extract has no concentration diversity to inhibit the fungi (P>0.05). On the other hand, the bacterium inhibition results demonstrate that the weak restrain effects of the Shar gaa extract. Regard to the gram positive bacteria (mainly including the S.aureas, Bacillus anthraci, Staphylococcus), the Shar gaa extract has the less effect to control the bacteria than the Penicillin group (P<0.05) and to the gram negative bacteria (the Pseudomonas) the Shar gaa extract has the less effect to control the bacteria than the Gentamicin group (P<0.05). Invalid of the drug-resistant E. coli and the P.mirabilis the Shar gaa extract group. The 20% Ethanol on bacterial group had no inhibitory effect. Conclusion: The Shar gaa extract possessed favourable inhibitory effect to frequent fungus and relative weak inhibitory effect to general bacterium in clinic. The research achievement not only expanded the new type of the Shar gaa -4 tan, but also developed the new usage of the Shar gaa-4 tan. It is to have the potential guide significance to clinical application.

Introduction. Garidi-5, a traditional medicine composed of 5 herbs including Terminalia chebula Retz., Aconitum Kusnezoffii Reichb., Acorus calamus L., Saussurea lappa L., and musk of Moschus moschiferus, has been used in traditional Mongolian medicine as an analgesic and antibacterial medicine. The present work was undertaken to evaluate the traditional drug Garidi-5 for its analgesic and anti-inflammatory activity.Materials and Methods. The method of Winter et al. was used to study acute inflammation. Rats in groups of five each were treated with vehicle, Garidi-5 (20, 80 and 200 mg/kg, p.o.) and Indometacin (10 mg/kg) one hour prior to Carrageenan injection. 0.1 ml of 1% Carrageenan was injected into the subplantar tissue of left hind paw of each rat. Swelling of carrageenan injected foot was measured at 0, 0.5, 2, 4 h using Plethysmometer (UGO Basile, Italy)). The right hind paw was injected with 0.1 ml of vehicle.Results. The Garidi-5 (20, 80 and 200 mg/kg) significantly (P<0.01) inhibited carrageenan induced rat paw edema as compared to control group. Maximum inhibition of paw edema was observed with Garidi- 5 (80 and 200 mg/kg) at 4 h when compared to the control group (Tab.1). In assay data, the TNF-α, IL-1β and IL-6 secretion in serum were highly elevated by carrageenan induction but administration of Garidi-5 signifi cantly reduced serum secretion of inflammatory mediatorsas compared to vehicle group (Tab. 2).Conclusion. In conclusion, Traditional drug Garidi-5 have anti-in flammatory properties. The potential efficacy of Garidi-5 to treat inflammation is based in a part on the hy pothesis that it will suppress the proinflammatory cytok ines resulting in less oedema.

Introduction. Garidi-5, a traditional medicine composed of 5 herbs including Terminalia chebula Retz. Aconitum Kusnezoffii Reichb., Acorus calamus L., Saussurea lappa L., and musk of Moschus moschiferus, has been used in traditional Mongolian medicine as an analgesic and antibacterial medicine. The present work was undertaken to evaluate the traditional drug Garidi-5 for its analgesic and anti-inflammatory activity.Materials and Methods. The method of Winter et al. was used to study acute inflammation. Rats in groups of five each were treated with vehicle, Garidi-5 (20, 80 and 200 mg/kg, p.o.) and Indometacin (10 mg/kg) one hour prior to Carrageenan injection. 0.1 ml of 1% Carrageenan was injected into the subplantar tissue of left hind paw of each rat. Swelling of carrageenan injected foot was measured at 0, 0.5, 2, 4 h using Plethysmometer (UGO Basile, Italy)). The right hind pawwas injected with 0.1 ml of vehicle.ResultsThe Garidi-5 (20, 80 and 200 mg/kg) significantly (P<0.01) inhibited carrageenan induced rat paw edema as compared to control group. Maximum inhibition of paw edema was observed with Garidi-5 (80 and 200 mg/kg) at 4 h when compared to the control group (Tab.1). In assay data, the TNF-α, IL-1β and IL-6 secretion in serum were highly elevated by carrageenan induction but administration of Garidi-5 signifi cantly reduced serum secretion of inflammatory mediators as compared to vehicle group (Tab. 2). ConclusionIn conclusion, Traditional drug Garidi-5 have anti-in flammatory properties. The potential efficacy of Garidi-5 to treat inflammation is based in a part on the hy pothesis that it will suppress the proinflammatory cytok ines resulting in less oedema.

Shoulder pain is the third common areas of musculoskeletal pain. Shoulder pain was originated from pathology which neck and upper thoracic spines and destabilize movement of shoulder girdle. Treatment of chronic shoulder pain was used by acupuncture in recent time. Therefore research studies increased and we made search Medline and found articles on biomechanics of shoulder complaint, when we consolidated articles on biomechanics of shoulder complaint. Then we coordinated results of consolidated articles to theory of the Chinese acupuncture meridians and collaterals. Findings of coordination biomechanics of shoulder complaints to theory of the Chinese acupuncture meridians and collaterals studies to improve diagnostics and acupuncture treatment of shoulder pain.

Garidi-5, a traditional medicine composed of 5 herbs including Terminalia chebula Retz., Aconitum Kusnezoffii Reichb., Acorus calamus L., Saussurea lappa L., and musk ofMoschus moschiferus, has been used in traditional Mongolian medicine as an analgesic and antibacterial medicine. The aim of the study was to evaluate the central and peripheral analgesic action of traditional mongolian drug Garidi-5 in experimental animal models. Analgesic activity was assessed by tail flick method (for central action) and l acetic acid- induced writhing test (for peripheral action). Garidi-5 extract (20 mg/kg, 80, 200mg/kg p.o.) and aspirin (100 mg/kg) showed significant peripheral analgesic activity (p<0.05). Garidi-5 extract (20 mg/kg, 80, 200mg/kg p.o.) and Morphin (10 mg/kg, i.p.) also showed significant central analgesic activity (p<0.05). Conclusion: Biological activity substances were detected in the Traditional drug Garidi-5. Traditional drug Garidi-5 has analgesic effects.

Medicine has history of more than 3000 years, and it’s one of the most valuable heritages people in the world. During this long period, although it is still keeping itsown distinct features. Medicine had been developed in close relationship with Indian Ayurvedic medicine, Tibetan medicine and Chinese medicine, Hippocratic medicine, Avicenna medicine for many centuries (for long history period). Above mentioned medicines have the own diagnosticmethods and treatment. The services provided by practitioners of medicine covered the whole health-care spectrum and dealt less satisfactorily with most of the health problems at that time. However, researchers are facing to answer the following questions, what is medicine, what is medical science, what criteria should have treated in medicine by the modern time? For this reason, we need to study how medicine had been developed in particular part of the world especially in India, Tibetan, Greece and etc. Furthermore, main task of the researchers is included in identifying hypothetic criterion which is related to specific characteristicsdifferent fields of medicine. In addition, future perspectives and the latest achievements of scientific research into new medicine will be presented. The study explains the thoughts, theories and diagnostics and treatment- methods. We expect that study will demonstrate clearly updated (comprehensive) review of the origin and development of medical theories thoughts. This review states traces in the history of medicine and its special characteristics and achievements of during the historical period.

Acupuncture and moxibustion are an important component of Traditional Mongolian Medicine with a long history. As early as the new Stone Age in Mongolian territory, primitive human beings used the stone needles, the earliest acupuncture instrument, to treat diseases. The activities of human beings appeared in Mongolian territory about 800000 years ago. We mentioned about the History of Acupuncture and Moxibustion in the chapter one. In this time, I am going to explain how to set up the Sect of Acupuncture and Moxibustion based on some of the Chinese medical books between the end of 17th and the beginning of 18th centuries. Sect of Acupuncture and Moxibustion established through the Great Compendium of Acupuncture and Moxibustion by Yang Ju Zhou (1601), in the end of 17th and the beginning of 18th centuries in the Western part of Mongolia. The 17-18th century, students of Namkhaijamts, Zaya bandida and Oirad have translated as acupuncture and moxibustion books from Chinese into a Mongolian script that is named “Tod (one of the ancient Mongolian letters)”. A collection of acuptuncture books, the rich inheritance of Tod and the Kalmykia nationality also translated in 1997 into Russian and a book was printed titled “Traktati ob igloukalivanii i prijiganii – Scripture on Moxibustion.” In 1648, the great Zaya Bandid created the Mongolian letter “Tod,” and tried to spread it throughout Mongolia with the assistance of his students. They translated many books from Tibetan and also translated some selected acupuncture and moxibustion books from Chinese. From some historical facts, we see Western Mongols willing to be independent and to have their own letters and they tried to develop philosophy and its related sections within their own communities. It should be understood that in 1640, 44 people including Baatar prince, Subeedei king of Khalkh, Guush king of Khoshood aimag, Janjaa khutagt lama and the Great zaya bandid Namkhaijamts met and set the law of Mongol Oirad with regard to to approval rights, province border and power. Translating acupuncture and moxibustion books from Chinese into Mongolian initiated the beginning stage of the development of a new, understanding and theory. First of all, Chinese health development strongly influenced the special position acupuncture occupied. For instance there are some works such as Zheng Zi-He “Ru Men Shi Qin,” 1228, Hua Shou “Shi Si Jing Fa Hui,” 1341, Zhu Zhen-Hen “Dan Xi Xin Fa,” 1347, and “Zhen Jui Da Cheng,” in 1601. It is certain that the educated Mongolians had tried to consider and develop some of these works. Under the Chinese influence a well- known Korean doctor had written a book titled “Eastern health science dictionary,” in the northern part of Korea. This work is the first and most classic book in northern Korea. Even though Buddhism spread strongly in Mongolia, Western Mongols were comprised of many types of nomads with different nationalities and genetics, so their psychology and wisdom is different and people living in this area viewed society from many different perspectives. The academician Ch.Dalai explained the abovementioned matter represented by the great Zaya bandida; “It is very clear from his state and religious leading activities that Zaya bandida viewed everything from a central view and with wide aspects. He knew both theories of a governing state and the religion that great Mongolian kings inherited. Therefore he is a scientific lama who tried to implement both points of view. Unfortunately this health science trend that was based on the above was not developed because of Buddhism that spread strongly in all strata of Mongolian society and was snowed under the Buddhism in Oirad 1 .” Later local research museum officer Sambuu, in Uvs aimag, Mongolia found notes from Grandma Rolmaa or Dulmaa, Uriankhai–etnic group in 1959, and he brought them to the library of literature institute and gave them to Professor B. Rinchin. He took photos and wrote the foreword and printed 500 copies of a text which was titled “Collected notes of acupuncture,” in 1967. In his foreword he said, “Here there are many things to study from the perspective of literature and also the difference of this inherited slang and phrases of “Tod,” letter that was used in literature from Indian and Tibetan literature.” Further he mentioned, “Those two volumes published are related to many aspects, and also present many issues for our scientists and Mongolism researchers.” This book has six volumes (some say 10) but in the above publication it was only printed 4 and 6 volume annotations. Other notes could not be preserved until today.