Angiomatoid Spitz nevus is a variant of melanocytic nevus with prominent vasculature. Due to its pathologic features, angiomatoid Spitz nevus in the vaginal wall is extremely rare. A 42-year-old woman presented to the hospital with abnormal vaginal bleeding. Vaginal examination revealed a 2×2-cm well-demarcated tumor on the posterior wall of the vagina. The mass was successfully removed by complete excision and was diagnosed as angiomatoid Spitz nevus on pathologic examination. We present the first reported case of vaginal angiomatoid Spitz nevus, which caused vaginal bleeding. Although angiomatoid Spitz nevus has many histopathological similarities with malignant melanoma, precise histopathological diagnosis is important for preventing overtreatment.
Adult ; Diagnosis ; Female ; Gynecological Examination ; Humans ; Medical Overuse ; Melanoma ; Nevus, Epithelioid and Spindle Cell ; Nevus, Pigmented ; Uterine Hemorrhage ; Vagina

No abstract available.
Nevus, Epithelioid and Spindle Cell*

Hyalinizing Spitz nevus was first introduced in 1994 by Suster. It is considered a rare variant in the spectrum of Spitz nevus, with only a dozen cases having been reported to date. Herein we report a case of a 28-year-old Korean woman who had a brown papular lesion on the left palm, which was diagnosed as hyalinizing Spitz nevus. Upon histopathological investigation, discohesive growth patterns of nevus cells in a hyalinized stroma were noted. Immunohistochemical stains showed positive reactivity of nevus cells with S-100 protein and vimentin, but negative stains with HMB-45 and CD68. This case demonstrates a rare variant of Spitz nevus located on an unusual site, and calls for awareness in the diagnosis of cutaneous lesions that histologically exhibit a prominent hyalinized stroma.
Adult ; Biopsy ; Coloring Agents ; Diagnosis ; Diagnosis, Differential ; Female ; Humans ; Hyalin* ; Nevus ; Nevus, Epithelioid and Spindle Cell* ; S100 Proteins ; Vimentin

Spitz nevus is a benign melanocytic nevus, common in children or young adults, and it has histological features that are confused with those of malignant melanoma. Polypoid Spitz nevus is the benign counterpart of polypoid malignant melanoma. A 22-year-old woman presented with a solitary 1.5×1.5 cm-sized firm polypoid erythematous nodule on the left thigh. On dermoscopy, pink to yellowish lagoons intermingled by white fibrous septa were found but milky red globules or irregular linear vessels were not found. Therefore, melanoma almost could be ruled out cautiously. Histopathology showed symmetrical, well-circumscribed, polypoid architecture with predominant dermal nests of spindle cells. Immunohistochemically, the nevus cells were strongly positive for S-100 protein and negative for HMB-45. Thus, the diagnosis of polypoid Spitz nevus was made. Herein, we report a case of polypoid Spitz nevus that was differentiated from polypoid melanoma by histopathologic and dermoscopic findings.
Child ; Dermoscopy ; Diagnosis ; Female ; Humans ; Melanoma ; Nevus ; Nevus, Epithelioid and Spindle Cell* ; Nevus, Pigmented ; S100 Proteins ; Thigh ; Young Adult

No abstract available.
Nevus, Epithelioid and Spindle Cell*

Spitzoid melanoma is a subtype of melanoma that, clinically and histologically, resembles a Spitz nevus. Clinically, spitzoid melanomas usually evolve from amelanotic nodular lesions, growing to 1 cm or more in diameter. They often remain clinically undiagnosed because of their wide variety of clinical appearances and a lack of pigmentation. Distinguishing a Spitz nevus from a spitzoid melanoma can be extremely difficult. Features that favor the diagnosis of a spitzoid melanoma are asymmetrical shape, diameter greater than 1 cm, a lesion with a deep invasive component, and a high degree of cytologic atypia. There have been only rare reports in the literature of the presence of giant cells in malignant melanoma, and the presence of these cells may result in its misdiagnosis as a histiocytic tumor. We present a case of spitzoid melanoma on the right ankle of a 22-year-old-woman.
Ankle ; Diagnosis ; Diagnostic Errors ; Giant Cells ; Melanoma* ; Nevus, Epithelioid and Spindle Cell ; Pigmentation

No abstract available.
Child* ; Humans ; Nevus, Epithelioid and Spindle Cell*

No abstract available.
Nevus, Epithelioid and Spindle Cell*

Deep penetrating nevus (DPN) is a distinctive melanocytic nevus firstly reported by Seab et al. in 1989. It is characterized by its dark pigmentation, occurring mostly on the face, neck, or shoulder, and usually measures less than 1 cm in diameter. Since it has histologic similarities with other cutaneous pigmented lesions such as combined nevus, blue nevus, Spitz nevus, and pigmented spindle cell nevus, it is often difficult to diagnose and it may be clinically and histologically mistaken for a malignant melanoma. There have been 2 reported cases of DPN in the Korean dermatologic literatures; therefore, we report a case of DPN mimicking malignant melanoma.
Melanoma ; NAD ; Neck ; Nevus ; Nevus, Blue ; Nevus, Epithelioid and Spindle Cell ; Nevus, Pigmented ; Nevus, Spindle Cell ; Pigmentation ; Shoulder

Atypical Spitz's nevus is a rare spitzoid melanocytic proliferations with an uncertain malignant potential. Atypical Spitz's nevus have overlapping features of both Spitz nevi and spitzoid melanoma, and consequently, generate controversies with diagnosis and management. Herein, we report a case of atypical Spitz's nevus developing on the lower right leg of a 46-year-old man. Histologically, the lesion shows numerous uniform nests of spindle cells and epithelioid cells in the dermis. The lesion had a high Ki-index, prominent cellular density, but not enough to consider a diagnosis of melanoma. The nevus was removed by total excisions. No recurrences or metastases were detected during the follow-up period of 6 months.
Adult ; Dermis ; Epithelioid Cells ; Follow-Up Studies ; Humans ; Leg ; Melanoma ; Neoplasm Metastasis ; Nevus ; Nevus, Epithelioid and Spindle Cell ; Recurrence