Humans ; Neurothekeoma/surgery* ; Skin Neoplasms/surgery* ; Soft Tissue Neoplasms

No abstract available.
Eyelids ; Mucocele ; Neurothekeoma

Cellular neurothekeoma (CNT) is an uncommon variant of neurothekeoma that is composed of pithelioid to spindled cells with variable nuclear atypia or pleomorphism but no myxoid stroma. CNT occurs predominantly in the head and neck or upper trunk of children and young adults, with female predominance. The following case is different from typical CNTs. An 88-year-old female presented with a palpable mass on the scalp, which we excised. Histologically, the tumor was non-encapsulated and composed of spindled and epithelioid cells arranged in fascicles and nodules separated by a collagen-rich stroma. Immunohistochemical analysis showed that the epithelioid and spindle-shaped cells were focally positive for vimentin, neuron-specific enolase, smooth muscle actin, CD68, and CD10 but negative for S-100 protein, HMB-45, epithelial membrane antigen, and CD34. We report a new case of CNT that arose in the scalp of an older patient and that was associated with uncommon clinical, histological, and immunohistochemical profiles.
Actins ; Aged* ; Aged, 80 and over ; Child ; Epithelioid Cells ; Female ; Head ; Humans ; Mucin-1 ; Muscle, Smooth ; Neck ; Neurothekeoma* ; Phosphopyruvate Hydratase ; S100 Proteins ; Scalp* ; Vimentin ; Young Adult

Cellular neurothekeoma (CNT) is an uncommon variant of neurothekeoma that is composed of pithelioid to spindled cells with variable nuclear atypia or pleomorphism but no myxoid stroma. CNT occurs predominantly in the head and neck or upper trunk of children and young adults, with female predominance. The following case is different from typical CNTs. An 88-year-old female presented with a palpable mass on the scalp, which we excised. Histologically, the tumor was non-encapsulated and composed of spindled and epithelioid cells arranged in fascicles and nodules separated by a collagen-rich stroma. Immunohistochemical analysis showed that the epithelioid and spindle-shaped cells were focally positive for vimentin, neuron-specific enolase, smooth muscle actin, CD68, and CD10 but negative for S-100 protein, HMB-45, epithelial membrane antigen, and CD34. We report a new case of CNT that arose in the scalp of an older patient and that was associated with uncommon clinical, histological, and immunohistochemical profiles.
Actins ; Aged* ; Aged, 80 and over ; Child ; Epithelioid Cells ; Female ; Head ; Humans ; Mucin-1 ; Muscle, Smooth ; Neck ; Neurothekeoma* ; Phosphopyruvate Hydratase ; S100 Proteins ; Scalp* ; Vimentin ; Young Adult

No abstract available.
Neurothekeoma* ; Scalp*

Neurothekeoma is a rare cutaneous neoplasm, occurring as a cutaneous papule or nodule on the face, shoulders, and upper extremities. Neurothekeoma has been subclassified as either the myxoid, cellular, or mixed type, depending on the amount of myxoid matrix and on immunohistochemical analysis. We observed a clinical case with conflicting histopathological and immunohistochemical findings. In this case, microscopic examination showed the typical presentation of myxoid neurothekeoma; however, immunohistochemical staining was negative for S100 protein and positive for CD68, which is the characteristic pattern of cellular neurothekeoma. We report a very rare form of myxoid cellular neurothekeoma of the face in a young woman.
Female ; Humans ; Neurothekeoma* ; Shoulder ; Upper Extremity

PURPOSE: Nerve sheath myxoma is a rare cutaneous neoplasm originating from the peripheral nerve sheath and divided into three groups : myxoid, cellular and mixed type. There is a controversy on it's origin whether schwannian cell or perineurial differentiation, or anything else. Myxoid nerve sheath myxoma is asymptomatic, soft, papule or nodule in middle-age adults. We report a case of myxoid nerve sheath myxoma on the fingertip. METHODS: A 53-year-old woman presented with a painful, 0.4 x 0.4 x 0.6 cm sized, corn shaped nodule on the left 3rd fingertip. We put into surgical excision and studied it by histopathologically and specific immnohistochemical stain. RESULTS: The tumor has well defined nodules separated by thin fibrous connective tissue with abundant myxoid stroma and were positively stainded for S-100 protein, NSE and GFAP. After surgical treatment it was healed without recurrence. CONCLUSION: Nerve sheath myxoma is rare neoplasm and located mainly on face, but very rarely on the fingertip. We report a case of painful myxoid nerve sheath myxoma located on the 3rd fingertip.
Adult ; Connective Tissue ; Female ; Humans ; Middle Aged ; Neurothekeoma ; Peripheral Nerves ; S100 Proteins ; Zea mays

Neurothekeoma is a benign dermal soft tissue tumor that is probably of nerve sheath origin. It usually presents as a slow-growing, solitary papule or nodule that is mainly located on the head and neck or upper extremities except for the hand. There are three histologic subtypes - myxoid, mixed and cellular type - depending on the amount of myxoid stroma. Immunohistochemical markers such as S-100, glial fibrillary acidic protein, nerve growth factor receptor, NK1C3 (CD57) and Ki-M1p can be applied to the tumor cells to distinguish among thesethree subtypes of neurothekeoma. Only one case has been previously reported on the hand in Korea. Herein, we report a rare case of myxoid neurothekeoma on the hand with a review of the related literature.
Glial Fibrillary Acidic Protein ; Hand ; Head ; Korea ; Neck ; Nerve Growth Factor ; Neurothekeoma ; Upper Extremity

Cellular neurothekeoma is a rare, benign, cutaneous neoplasm of uncertain histogenesis and usually presents as a solitary papule or nodule on the head or neck area of children and young adults. Cellular neurothekeoma was thought to represent a cellular variant of nerve sheath myxoma but this neoplasm is histologically different from nerve sheath myxoma. Cellular neurothekeoma is characterized by a fasciculated, somewhat well-circumscribed proliferation of epithelioid and spindle cells. Herein, we report a case of cellular neurothekeoma with a review of related literature.
Child ; Head ; Humans ; Neck ; Neurothekeoma* ; Young Adult

Nerve sheath myxoma(NSM) is rare benign neoplasm of the dermis, divided into myxoid, cellular and mixed types. Myxoid NSM is asymptomatic, soft, skin colored or translucent papule or nodule in middle-aged adults and typically located on the face and the upper extremities. We, herein, reported a case of myxoid NSM in a 3 1-year -old male who had a painful, 1 X 1cm sized, dome-shaped nodule on the left sole.
Adult ; Dermis ; Humans ; Male ; Neurothekeoma* ; Skin ; Upper Extremity