1.Study of some bioactive substances contained in dry extracts of cultivated Inula helenium L. plant
Bujinlkham B ; Sugarmaa B ; Batdorj D ; Ganchimeg G ; Saikhanbayar P ; Munkhzaya B ; Maral L ; Badamtsetseg S ; Lkhaasuren R ; Akhtolkhyn T
Mongolian Pharmacy and Pharmacology 2024;25(2):29-37
Introduction:
Since 1993, the Inula helenium L. plant has been planted in the production area (Bulgan
Province, Dashinchilen Sum) of the Traditional Hatchery Science and Production Corporation’s medicinal
plant introduction and cultivation experience. At the Drug Research Institute, there is also a botanical institute
for medicinal plants where it is grown. In traditional Mongolian medicine, the roots and rhizomes of Inula
helenium L. are used to reduce inflammation, boost immunity, enhance hunger, and improve intestinal
motility. Inula helenium L. roots and rhizomes contain biologically active compounds such as monoterpenes,
sesquiterpenes, phenols, flavonoids, and polysaccharides.
Methods:
The roots and rhizomes of Inula helenium L. were extracted with water and 70% ethanol at the
following ratios 1:10 (2% of WAC), 1:8, and 1:6 by partial maceration at 700C for 2 hours each, extracted
and concentrated. The dry extract was obtained by the spray drying procedure. High-performance liquid
chromatography for determining the content of alantolactone, thin-layer chromatography for qualitative
analysis. Spectrophotometer for determining the content of polyphenolic compounds, colored compounds
with Folin-Ciocalteu reagent for qualitative analysis. Spectrophotometer for determining the content of inulin, and colored compounds with phenol and sulfuric acid solutions for qualitative analysis.
Conclusion
In determining the content of polyphenolic compounds, inulin, and alantolactone in the dry extract
taken from the roots and rhizomes of cultivated Inula helenium L., the content of polyphenolic compound in dry extract A was 2.50±0.08%, and alantolactone was 1.39±0.11% in the raw material of the plant, while B dry the extract had a high concentration of inulin of 58.51±0.66%.
2.A review of clinical research on the five medicinal herb soak therapy
Enkhbold G ; Badamtsetseg S ; Munkhzaya B ; Lkhaasuren R ; Khurelbaatar L
Mongolian Pharmacy and Pharmacology 2024;25(2):100-110
Introduction:
The Five Medicinal Herb Soak Therapy, as described in the 23rd chapter of “The Secret
Quintessential Instructions on the Eight Branches of the Ambrosia Essence Tantra,” a key text in traditional medicine, is noted for its therapeutic applications. It is recommended for conditions such as joint stiffness, tumors, acute and chronic wound swelling, sores, abscesses, hunchback, muscle rheumatism, anthrax, scattered heat and wind disorders. The Five Medicinal Herb Soak consists of Ledum palustre L., Juniperus pseudosabia Fisch.Et M., Myricaria alopecuroides Schrenk., Ephedra Przewalskii Stapf., and Artemisia frigida Willd. This therapy is widely practiced in Mongolia, China, the Inner Mongolia Autonomous Region, the Tibetan Autonomous Region, the Qinghai Province, and the Gansu Province. This clinical observational study review aims to predict treatment outcomes, establish treatment guidelines, and facilitate the development of other pharmaceutical forms. It is anticipated that this review will serve as a scientific reference for the application of the Five Medicinal Herb Soak Therapy.
Objective:
The objective of this review is to analyze and synthesize clinical studies on the Five Medicinal
Herb Soak Therapy.
Methods:
Keywords “五味甘露” (Wu wei gan lu), “Tibetan medicine five-flavor Manna” were used to search
for relevant research articles and theses in biomedical databases, including PubMed (https://pubmed.ncbi.
nlm.nih.gov/) and the China National Knowledge Infrastructure CNKI (https://www.cnki.net/). The collected
data were systematically analyzed and reviewed.
Conclusion
The Five Medicinal Herb Soak Therapy demonstrates significant therapeutic value in treating
conditions such as gout, rheumatic joint inflammations, digestive disorders, female reproductive system
diseases, spinal herniation, arthritis, varicose veins, and scurvy. Integrating this therapy with Mongolian,
Tibetan, Chinese, and European medical practices can enhance treatment efficacy by reducing treatment
duration, alleviating symptoms, and preventing recurrence. Furthermore, developing more efficient
pharmaceutical forms of the Five Medicinal Herb Soak could improve its effectiveness and reduce potential
side effects.
3.BI-RADS assessment using for diagnosis of invasive ductal carcinoma
Munkhzaya S ; Ariuntungalag B ; Nasantogtokh E
Mongolian Journal of Obstetrics, Gynaecology and Pediatrics 2021;29(1):2110-2113
BI-RADS assessment using for diagnosis of invasive ductal carcinoma
Introduction: Scientific evidence is needed to introduce non-invasive and effective diagnostic methods for early detection of breast cancer. One of these methods is the BI-RADS (Breast Imaging Reporting and Data System) assessment, which has entered the field of imaging. However, in the United States, 58% of all cases diagnosed negatively by ultrasound (BI-RADS1-3) were diagnosed by breast biopsy. The significance of BI-RADS assessment in Invasive Ductal Carcinoma will be investigated in the National Cancer Center of Mongolia
Materials and methods: The study was conducted using the descriptive design from January 2021 to August 2021, based on the National Cancer Center of Mongolia. The study data were initially collected using a database of tissue and immunohistochemical analyzes and breast ultrasound. Of the 75 women aged 23-86, 81.3% were diagnosed with breast cancer.
Results: The study found that 75.4% of women diagnosed with breast cancer by biopsy had a suspected BI-RADS cancer (4a-5). In addition, a woman's age is a statistically significant predictor variable in the diagnosis of peritoneal breast cancer (ROC = ROC = 0.736, p = 0.006).
Conclusions: BI-RADS assessment can be used for invasive ductal carcinoma. Our study retrospectively included only women with cancer and other breast disease. In the future, it is necessary to study in detail the relationship between BI-RADS evaluation indicators and invasive ductal carcinoma.
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