Background: Musculoskeletal disorders account for 23.1-47.1% of occupational diseases in several countries. Studies have shown that operators of heavy machinery, including tractors and dump trucks, are twice as likely to experience lower back pain compared to workers not exposed to whole-body vibration. Furthermore, research has indicated that acute exposure to vibration can cause vasoconstriction and vascular inflammation. However, limited research has explored the relationship between lower back pain and specific biomarkers, highlighting the need for this study. Aim: This study aimed to compare lower back pain prevalence and muscle inflammation biomarkers among heavy machinery operators. Materials and Methods: A purposive sampling method was used to recruit 15 male participants aged 25-35 years who had worked as heavy machinery drivers for no more than three years. Inclusion criteria were: no alcohol consumption within 24 hours prior to sampling, body mass index (BMI) between 18.5-28.9 kg/m², no prior diagnosis of musculoskeletal disorders, and absence of infectious or non-infectious diseases during the study period. Blood samples were analyzed for Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-α) levels using enzyme-linked immunosorbent assay (ELISA). Results: The mean BMI of participants was 25.89±3.23 kg/m². Over half (53.3%, n=8) exceeded the exposure limit for whole-body vibration. Low back pain was reported by 13 participants (86.7%) over the past six months and by 12 participants (80%) over the past seven days. TNF-α levels did not differ significantly between groups based on low back pain status or vibration exposure. However, IL-6 levels showed a significant increase 24 hours after whole-body vibration exposure (p=0.027). Conclusion Lower back pain was highly prevalent among participants exposed to whole-body vibration. Furthermore, IL-6 levels were elevated among participants reporting lower back pain, regardless of vibration exposure levels.

Background: Obesity, especially central obesity, is a risk factor for non-communicable chronic diseases such as dyslipidemia, type 2 diabetes mellitus (T2DM), cardiovascular diseases (CVD), and metabolic syndrome (MetS). Aim: Study the association between the subcutaneous fat area (SFA) and visceral fat area (VFA) with lipid metabolism parameters in adults with MetS. Materials and Methods: Data from 1511 participants who visited the ‘NURA Mongolia’ Ai Health screening center between September 2023 and February 2024, including general information, DEXA (Dual X-ray Absorptiometry), and biochemical analysis results, were used. Metabolic syndrome (MeS) was assessed based on the harmonizing criteria 2009 (≥3 criteria). VFA and SFA were categorized into four groups using quartiles (Q1-Q4). Statistical analysis was performed using SPSS v26, including T-tests, multiple logistic regression (OR, 95% CI), and ROC (AUC) analysis. Results: The average age of the participants was 30.5±3.9 years, with a BMI of 25.1 kg/m², and 49.5% were male. The group with MetS (n=531) had significantly higher levels of VFA and SFA compared to the group that rated their health as relatively healthy and had no clinical diagnosis (n=979) (control group) (p<0.0001), with males showing higher VFA and females showing higher SFA (p<0.0001). The Q4 group for VFA had a significant association with MetS in males (4.611, 95% CI=2.394–9.591) and females (2.253, 95% CI=1.097-3.912) (p<0.001). Logistic regression analysis showed that increased VFA was more strongly associated with MetS in males (β=0.325, p<0.0001) and females (β=0.338, p<0.003) than BMI. The AUC for predicting MetS was 0.790 (95% CI=0.750-0.831) for VFA and 0.401 (95% CI=0.351-0.451) for SFA, with all results being statistically significant (p<0.001). VFA had a higher predictive value compared to other markers. Conclusion In healthy men with metabolic syndrome, VFA is more prominently defined, while SFA is higher in healthy women. Since VFA is a better predictor of metabolic syndrome than SFA, it increases the risk of diseases such as cardiovascular diseases and type 2 diabetes in men, whereas SFA in women serves as a protective factor.

Background: Diabetes mellitus (DM) is a complex metabolic disorder involving many organs and can devastate the lives of affected individuals. It is characterized by chronic high blood glucose that could lead to morbidity and mortality. The number of people suffering from diabetes worldwide is increasing at an alarming rate. It is predicted that about 366 million people are likely to be diabetic by the year 2030. Since all of the previous studies have focused on the therapeutic role of (Allium polyrhizum Turcz. ex Regel) preparations in diabetes mellitus, we investigated the preventive effect of oral administration of (Allium polyrhizum Turcz. ex Regel) extract on the changes of biochemical factors and histopathology alterations in hepatic tissue caused by diabetes. Therefore, this study aimed to investigate the effect of water extract (Allium polyrhizum Turcz. ex Regel) on the metabolism of rats with diabetes induced by a high-fat diet and streptozotocin. Aim: To investigate the antidiabetic properties of aqueous extract of (Allium polyrhizum Turcz. ex Regel) and its beneficial effect on hematological parameters in streptozotocin-induced diabetic rats. Materials and Methods: Experimental was performed at the Institute of Mongolian Medicine and Chemistry, Inner Mongolia University. Male Wistar rats weighing (180 g) were obtained from The Animal Experimental Unit of Mongolia Medicine and Chemistry Research Center, Inner Mongolia University. The rats were housed in well-aerated individual cages in an animal room and maintained in a temperature-controlled room (24±25°C) with a 12 h light/12 h dark cycle, 50-60 % humidity. They were fed with normal commercial chow and water ad libitum. Throughout the experiments, animals were processed according to the suggested international ethical guidelines for the care of laboratory animals, and all experimental procedures were approved by the Animal Care and Use Committee of Inner Mongolia University. After 4 weeks, the rats were fasted for 8 h before blood sampling, water was not restricted. Blood samples were collected from the orbital venous plexus. Results: The blood glucose level was significantly increased in model group 24.14±2.28 mmol/L, to Control group 5.31±0.49 mmol/L. Oral administration of Allium polyrhizum Turcz.ex Regel treated group 10.5±4.05 mmol/L, Metformin treated group 9.05±2.71 mmol/L resulted in significantly decreased blood glucose levels less model group. Conclusion The results of this study indicate that Allium polyrhizum Turcz.ex Regel possesses hypoglycemic, hypolipidemic, and antioxidant effects in STZ-induced diabetic rats and therapy of diabetes and its complications especially when used for a longer period.

Background: In traditional medicine, the Shimshin-6 formulation, which consists of Rheum undulatum L., Hippophae rhamnoides L., Zingiber officinalie Roscoe, Saussurea Lappa C.B.Clark, Sal ammoniacum, Tronae veneni, is recommended for women experiencing menstrual retention disorders. In recent years, Shimshin-6 has been widely used to promote postpartum uterine involution for women and our study aimed to evaluate and determine the acute and chronic toxicity effects of Shimshin-6. Aim: To evaluate and substantiate the acute and chronic toxicity effects of Shimshin-6. Materials and Methods: The acute toxicity of Shimshin-6 was evaluated using the rapid method described by V.B. Prozorovsky (1978) by administering intraperitoneal injections of the medicinal extract in white mice to determine the lethal dose. The active dose was determined following the methodology of I.P. Zapadnyuk (1983). Chronic toxicity was evaluated in Wistar rats according to the OECD 407 (2008) guidelines. The test animals were administered Shimshin-6 in tablet form (90 mg/kg and 180 mg/kg) and decoction form (tang) (162 mg/kg) daily for 60 days. At the end of the experiment, biochemical and complete blood analyses were conducted, along with histopathological examination of major organs. The study was conducted with ethical approval granted by the Ethics Committee of the Mongolian National University of Medical Sciences (MNUMS) on October 25, 2024. Results: The LD50 for Shimshin-6 tablets was 4.47 (3.39–5.1) g/kg, indicating low acute toxicity based on the K.K. Sidorov classification. The LD50 for the decoction form was 8.1 (7.1–9.4) g/kg, suggesting it is non-toxic. Regarding chronic toxicity, platelet count was significantly reduced compared to the healthy control group: Shimshin-6 tablet group: 46% reduction at 90 mg/kg and 29.7% reduction at 180 mg/kg. Shimshin-6 decoction group: 60.5% reduction at 162 mg/ kg. Additionally, hemoglobin levels in the decoction group (162 mg/kg) decreased by 15.7% (p<0.05). Biochemical analysis showed a 36.3% reduction in total cholesterol (LDL-C) levels in the tablet group (180 mg/kg) and decoction group (162 mg/kg) compared to the control (p<0.05). Conclusion Shimshin-6 tablets showed low acute toxicity in experimental mice. However, long-term administration may lead to a reduction in platelet count.

Background: This study explores the potential of food industry by-products, such as plant peels, stems, and slags, as valuable sources of lignocellulosic material (LCM), which contains 25-40% xylan. These underutilized resources, often discarded as waste, hold the promise of sustainable applications in biotechnology. By safely extracting xylooligosaccharides (XOS) from LCM biomass, the value of these materials can be significantly enhanced, contributing to green production and supporting sustainable development. XOS, recognized for its prebiotic activity, has been shown to promote the growth of beneficial gut bacteria, making it a vital research area in the fields of food science, medicine, and technology. Aim: To extract and characterize oligosaccharides derived from by-products of the food industry, evaluate their physicochemical properties, and investigate selected biological activities. Materials and Methods: This study utilized microwave pretreatment and enzymatic hydrolysis to isolate and purify XOS from wheat bran and brewers’ spent grains (BSG), provided by Altan Taria LLC and APU CoL, respectively. Microwave irradiation at 200°C for 5 minutes was employed as a pretreatment step, followed by hydrolysis using commercial xylanase (Thermomyces lanuginosus, recombinant Aspergillus oryzae, 2500 BXU/g) at 55°C for 24 hours. The resulting hydrolysate underwent filtration with activated carbon and ethanol precipitation to yield purified XOS. Analytical methods, including FTIR spectroscopy, TLC and HPLC, were used for structural and compositional analysis of the purified oligosaccharides. In vitro tests evaluated the ability of XOS to support the growth of beneficial gut bacteria, including Bifidobacterium spp., Lactobacillus fermentum (ATCC 9338), and Lactobacillus casei (ATCC 344), using XOS-enriched media. Additionally, in vivo studies were conducted on rats to determine the biological effects of XOS on gut microbiota. Results: The results demonstrated that prolonged enzymatic hydrolysis for more than 10 hours, using 0.25 g of xylanase per 100 g of substrate, resulted in optimal yields. XOS purity was measured at 87.6% with an 8.1 g yield from wheat bran and 89% purity with a 7.2 g yield from brewers’ spent grains. Structural analysis confirmed the presence of xylobiose, xylotriose, and xylotetraose, with xylotetraose being the most abundant component in WBP-XOS (47.5%), and xylobiose dominating BGS’s derived XOS (47.8%). Biological effects revealed that wheat bran-derived XOS significantly supported the growth of Bifidobacterium spp. and L. fermentum (ATCC 9338) in a concentration-dependent manner, whereas no significant effect was observed on L. casei (ATCC 344). In vivo studies confirmed that XOS consumption increased populations of Bifidobacterium spp. and Akkermansia muciniphila spp. in gut microbiota (p<0.05). Furthermore, XOS consumption reduced plasma cholesterol, triglycerides, and LDL-C levels while increasing HDL-C levels, demonstrating metabolic benefits. Conclusion This research establishes that XOS with prebiotic activity can be efficiently extracted and purified from food industry by-products using microwave-assisted enzymatic hydrolysis. This approach highlights the potential of utilizing agricultural and industrial waste for producing functional prebiotics, contributing to sustainable practices and offering valuable applications in health and nutrition.

Diets, boosting circulating ketones are used to use for treating some neurological disease. But recent years it’s usage in coordinating the weight is becoming more popular among overweight population. Weight loss is being offered as a therapy is aimed to reduce some risk factors of metabolic syndrome. Ketogenic diet offers high amount of fat in food composition and very low amount of carbohydrate. Results regarding the impact of ketogenic diet on cardiovascular risk factors and metabolic parameters are controversial and seem to be limited in time, which means it depends on lasting time of ketogenic diet. Ketogenic diet is not totally safe and can be associated with some beneficial and adverse effects on metabolism.

In December 2019, a group of patients with severe acute respiratory syndrome were diagnosed in Wuhan, Hubei Province, China. The virus that causes the disease is called SARS-CoV-2, and COVID-19 is spreading rapidly from Asia to Europe and around the world. New epidemics, such as the new coronavirus, acute respiratory syndrome (SARS-CoV), Middle East respiratory syndrome (MERS-CoV), and H1N1 influenza A, have been a warning to global health organizations. However, none of these pathogens have had such a catastrophic impact worldwide as the novel coronavirus SARS-CoV-2. RNA viruses known to possess very high mutation rate, which is associated with increased virulence and variability. This feature can also be seen in COVID-19, which has over 50 million cases with a mortality rate of 2.5% in 217 countries. The clinical spectrum of COVID-19 ranges from asymptomatic carriage, mild upper respiratory tract infection (URTI), severe viral pneumonia to acute respiratory distress syndrome (ARDS) and death. Research has led to identification of the angiotensin-converting enzyme (ACE) 2 as the cell-entry receptor for SARS-CoV-2. However, despite these findings, systematic studies of viral dynamics and the immune response of infected individuals have not been fully established.
Coronavirus vaccines are being developed around the world and are expected to produced in 2021, according to Australian researchers. However, there is a urgent need for evidence-based treatment against SARS-CoV-2.
This article summarizes the many studies that have been conducted on the effects of vitamins and minerals in the treatment of coronavirus infections.

Air pollution, including particulate matter and gases has been associated with cardiovascular and respiratory diseases, particularly in urban areas. More than 80% of world population lives in environment those exceed the air quality guideline established by World Health Organization. Air pollution is a very complex mixture and its potential to cause harm can depend on multiple factors including physical and chemical characteristic of pollutants. It has been hypothesized that the intake of anti-oxidant and anti-inflammatory nutrients may improve various respiratory and cardiovascular effects of air pollution through reductions in oxidative stress and inflammation. Several studies have suggested that essential micronutrients including B vitamins and Vitamin C, E and long-chain polyunsaturated fatty acids has potentials to modify oxidative and inflammatory stress. Here, we review literature related to air pollution and its health impact and how essential micronutrients can worsen its negative effect.

Background: Urinary incontinence is a common and distressful problem worldwide as well as in Mongolia. According to a survey conducted by Dr.Sanjsuren, 32.2% of participated woman were diagnosed with the urinary incontinence. To diagnose and treat this highly prevalent disease, it is important to know the most common types of incontinence in Mongolian woman and its risk factors. However, there is no known studies in Mongolia ultimately concentrated on the prevalence of common types of incontinence and its causes. Therefore, this study aimed at assessing the common types of incontinence among Mongolian woman and its key risk factors. Materials and Methods: We used a cross sectional data collected from the urogynecological cabinet based on the first maternal hospital in Ulaanbaatar from June to November 2016. 117 woman aged 20-80, who has incontinence symptoms participated in this study. The type of urinary incontinence is checked by urodynamical equipment “Uromic Samba”. Participants also answered a questionnaire with a purpose of assessing the risk factors. Results: Descriptive analysis shown that age, body weight, number of birth and type of delivery may be the key risk factors of incontinence. Foreinstance, the prevalence of incontinence was 6.8 % among woman aged 25-35 and increases with age 26.3 % at age 36-45, 36.4 % with age group 46-55, 30.5% with age 56-80 above respectively. According to the BMI, 81.2% percent of the participating woman with incontinence are obese. As a result of birth survey among total respondents, 59.3% had 3 or more deliveries. Association between incontinence and age, body mass index was found to be the strongest and type of the delivery was the weakest. 40% of total respondents have stress incontinence, 27% have mixed incontinence, 25% have urge incontinence, 8% have other type incontinance symptoms. Conclusion The most prevalent type of incontinence among Mongolian woman is stress incontinence followed by the urge incontinence. Delivery, body weight was associated with incontinence.

Introduction: Preeclampsia, which affects about 2-8% of pregnancies, is major cause of maternal and perinatal morbidity and mortality, particularly in developing countries. In Mongolia, preeclampsia and eclampsia occurred among pregnancy complications about 25% in recent years. There is a percentage for a cause of maternal death was 17.7% in preeclampsia and eclampsia between 2012 and 2015 in Mongolia.
Effective prediction of preeclampsia can be achieved at 11-13 week’s gestation by combination of maternal characteristics, mean arterial pressure (MAP), uterine artery pulsatility index (UtA PI), maternal serum placental growth factor (PlGF), and pregnancy-associated plasma protein-A (PAPP-A). Goal: To investigate plasma concentration of PIGF and PAPP-A, in pregnant women at 11-13+6 of gestation for screening of preeclampsia, To examine the performance of first-trimester screening for preeclampsia based on maternal characteristics, MAP, and mUt.A-PI. Materials and Methods : The study conducted among 393 single pregnant women at 11-13+6 weeks, who were visiting antenatal care services, between March, 2015 and June, 2017. The prospective Cohort research method was used for this study. Written informed consent was obtained from all participants. Maternal plasma PAPP-A, PlGF were determined using Perkin Elmer kits by fluoroimmunoassay.
Measurement of MAP was by validated automated devices (HEM-7120, Оmron, Japan). MAP was calculated from the formula DP + 1/3*(SP-DP), where DP represents diastolic blood pressure and SP- systolic blood pressure. Trans-abdominal ultrasound (Voluson E8, GE, USA) examination was carried out for Ut.A-PI. Results: In the study population, there were 66 (16.8%) cases that experienced preeclampsia and 327 (83.2%) cases that were unaffected by preeclampsia. The result showed that the mean concentration of PlGF was 38.6±19.6 pg/ml in PE group whereas the mean was 45.1±24.0 pg/ml in normal pregnant women. Level of PAPP-A was 366.1±195.3 mU/L in group with PE, 633.6±496.9 mU/L in group without preeclampsia.
The best Youden’s index and area under the curve (AUC) for MAP and mUt.A-PI were as a predictor of PE. It can be shown that the cutoff point for MAP was 89.5 mmHg (sensitivity-71.2%; specificity-75.5% J-0.467; AUC-0.792; P<0.001). The cutoff point of mUt.A-PI was 2.34 (sensitivity-33.3%; specificity-77.7% J-0.12; AUC-0.577; P<0.001). Conclusions The concentration of PIGF and PAPP-A in pregnant women with preeclampsia at 11-13+6 of gestation was lower than normal pregnant women. The detection risk of PE by MAP is more accurate than the mUtA-PI measurement.