OBJECTIVE: Reaction time is defined as the time from the start of a stimulus to the start of the voluntary movement. Time plays an important role in undertaking daily living activities. Reaction time is an important factor in respect of both quality of life and of capabilities demonstrated in the work environment. Alcohol and some addictive substances have effect on RT. The aim of this study was to compare the visual and auditory reaction times of patients with opioid use disorder with healthy control subjects. METHODS: The study was applied to two groups as the opioid use disorder group and the control group. A Sociodemographic and Clinical Data Form was prepared for each patient including age, gender, marital status and education level. Using a computer program the response to visual screen color change (red/blue) and to an auditory ‘beep’ sound of the computer system were recorded. The Student’s t-test was applied as a statistical method. RESULTS: The results showed longer reaction times in the patients with opioid use disorder. CONCLUSION: To add improving reaction time approaches in opioid use disorder treatment may contribute to treatment by increasing quality of life and work performance.
Activities of Daily Living ; Computer Systems ; Drug Users ; Education ; Heroin Dependence ; Humans ; Marital Status ; Methods ; Mortuary Practice ; Opioid-Related Disorders ; Quality of Life ; Reaction Time ; Work Performance

A non-physiological occlusal plane caused by continuous tooth loss, occlusal wear, and failure of a prosthesis may result in an unattractive appearance and functional problems, such as reduced masticatory efficiency and occlusal interference. Therefore, when undertaking prosthetic treatment for edentulous patients or patients with a collapsed occlusal plane, it is important to establish an occlusal plane that is compatible with masticatory function. The patient in this case report had undergone restoration of a completely edentulous maxilla using an implant-supported fixed prosthesis. On follow-up examination in the following 6 years, mechanical complications were observed in the existing implant prosthesis, including porcelain chipping, occlusal wear, and screw loosening. Moreover, due to occlusal wear and supraeruption of the opposing anterior teeth, as well as loss of some posterior teeth, the occlusal plane had collapsed. Following diagnosis, the patient underwent full mouth rehabilitation, involving additional implant installation in edentulous sites, recreation of the existing prosthesis, and prosthetic restoration of all remaining teeth.
Dental Occlusion* ; Dental Porcelain ; Diagnosis ; Follow-Up Studies ; Humans ; Maxilla ; Mortuary Practice ; Mouth Rehabilitation ; Prostheses and Implants* ; Recreation ; Tooth ; Tooth Attrition ; Tooth Loss

The objective of this study was to compare ovulation rate, number of large ovarian follicles, and concentrations of plasma progesterone (P4) and non-esterified fatty acids (NEFA) between lame (n = 10) and non-lame (n = 10) lactating Holstein cows. The study was conducted in an organic dairy farm, and cows were evaluated by undertaking ultrasonography and blood sampling every 3 days from 30 days postpartum for a period of 34 days. Cows which became lame during the first 30 days postpartum experienced a lower ovulation rate determined by the presence of a corpus luteum (50% presence for lame cows and 100% for non-lame cows, p ≤ 0.05). The number of large ovarian follicles in the ovaries was 5 for lame cows and 7 for non-lame cows (p = 0.09). Compared to non-lame cows, lame cows had significantly lower (p ≤ 0.05) concentrations of plasma P4. Furthermore, NEFA concentrations were lower (p ≤ 0.05) in lame cows than in non-lame cows. It is concluded that lameness in postpartum dairy cows is associated with ovulation failure and lower concentrations of P4 and NEFA.
Agriculture ; Corpus Luteum ; Fatty Acids ; Fatty Acids, Nonesterified ; Female ; Mortuary Practice ; Ovarian Follicle ; Ovary ; Ovulation ; Plasma ; Postpartum Period ; Progesterone ; Ultrasonography

Health policy is the governmental decision contained with the objectives to achieve the desirable health and the tools to achieve them. The academic journal in health policy could be involved in all stages of the health policy process–agenda setting, policy making, policy implementing, and policy evaluating. ‘Health Policy and Management’ has been undertaking the role of an academic society in health policy. ‘Health Policy and Management’ will strengthen its role in health policy.
Health Policy* ; Mortuary Practice ; Policy Making

Endoscopic retrograde cholangiopancreatography (ERCP) in a surgically altered anatomy is a technically challenging undertaking with variable success and adverse event rates. There are several potential challenges to successfully perform an ERCP in patients with surgically altered anatomy such as identification of afferent limb, accessing and visualization of the papilla, and selective cannulation of the biliary and pancreatic ducts from altered orientation of the papilla. Several strategies to improve the success rate have been recommended by various endoscopy experts. In this review, we discussed the published literature involving various ERCP techniques described for surgically altered anatomies.
Catheterization ; Cholangiopancreatography, Endoscopic Retrograde* ; Endoscopy ; Extremities ; Gastric Bypass ; Humans ; Mortuary Practice ; Pancreatic Ducts ; Pancreaticoduodenectomy

Ginseng gintonin is an exogenous ligand of lysophosphatidic acid (LPA) receptors. Accumulating evidence shows LPA helps in rapid recovery of corneal damage. The aim of this study was to evaluate the therapeutic efficacy of gintonin in a rabbit model of corneal damage. We investigated the signal transduction pathway of gintonin in human corneal epithelium (HCE) cells to elucidate the underlying molecular mechanism. We next evaluated the therapeutic effects of gintonin, using a rabbit model of corneal damage, by undertaking histochemical analysis. Treatment of gintonin to HCE cells induced transient increases of [Ca²⁺](i) in concentration-dependent and reversible manners. Gintonin-mediated mobilization of [Ca²⁺](i) was attenuated by LPA1/3 receptor antagonist Ki16425, phospholipase C inhibitor U73122, inositol 1,4,5-triphosphate receptor antagonist 2-APB, and intracellular Ca²⁺ chelator BAPTA-AM. Gintonin facilitated in vitro wound healing in a concentration-dependent manner. When applied as an eye-drop to rabbits with corneal damage, gintonin rapidly promoted recovery. Histochemical analysis showed gintonin decreased corneal apoptosis and increased corneal cell proliferation. We demonstrated that LPA receptor activation by gintonin is linked to in vitro and in vivo therapeutic effects against corneal damage. Gintonin can be applied as a clinical agent for the rapid healing of corneal damage.
Apoptosis ; Cell Proliferation ; Corneal Injuries ; Epithelium, Corneal ; Humans ; In Vitro Techniques ; Inositol 1,4,5-Trisphosphate ; Mortuary Practice ; Panax ; Rabbits ; Receptors, Lysophosphatidic Acid ; Signal Transduction ; Therapeutic Uses ; Type C Phospholipases ; Wound Healing* ; Wounds and Injuries*

BACKGROUND: Current National Health Examination (NHE) in Korea provides health examination to the public throughout the entire life course; however, management after NHE is not sufficiently delivered. In this study, we investigated knowledge and attitude of health care providers in order to revise result forms and counseling manual of NHE. METHODS: We recruited 30 doctors, who undergo NHE, and conducted survey from January 7, 2016 to January 26, 2016. Participants answered questionnaires regarding difficulty of explaining each items of result forms, difficulty of counseling each items of NHE, and ways of improvement. Furthermore, we conducted in-depth interview regarding pros and cons of NHE and improvements needed. RESULTS: The average Likert score for difficulty of explaining items of result forms was lowest (3.8/5.0 points) for blood test due to its graphic format. Difficult counseling items were mental health, mild cognitive impairment and dementia, and healthcare for the elderly. The proportions of doctors, who often counsel these items, were less than 40%. In the in-depth interview, health care providers suggested that examinees' knowledge for result forms decreases because it is hard to interpret, and management after NHE should be improved by undertaking NHE in primary health care facilities. CONCLUSIONS: The graphic format of blood test result form should be revised into readable format, and contents of counseling manual for mental health, mild cognitive impairment and dementia, and healthcare for the elderly should be improved. Financial support for doctors should be provided, and NHE should ultimately be reinforced in primary health care facilities.
Aged ; Counseling ; Delivery of Health Care* ; Dementia ; Financial Support ; Health Personnel* ; Hematologic Tests ; Humans ; Korea ; Mental Health ; Mild Cognitive Impairment ; Mortuary Practice ; National Health Programs ; Primary Health Care

Malignant gastric outlet obstruction describes a constellation of symptoms that can result as a common endpoint from a variety of primary tumours, particularly those of the upper gastrointestinal tract and pancreas. Affected patients face a dismal, undignified and rapid decline in health secondary to malnutrition, dehydration and constant nausea with associated vomiting. Palliative treatment has traditionally involved a gastrojejunostomy—a major undertaking given the functional status of these patients. More recent advances in the endoscopic placement of metal stents to relieve obstruction have clear benefits over the surgical method. We look at the factors involved in patient selection, the techniques and considerations involved in stent deployment and the potential complications associated with this method.
Dehydration ; Duodenal Neoplasms ; Endoscopy ; Gastric Outlet Obstruction ; Humans ; Malnutrition ; Methods ; Mortuary Practice ; Nausea ; Palliative Care ; Pancreas ; Patient Selection ; Stents ; Upper Gastrointestinal Tract ; Vomiting

OBJECTIVE: The aim of this study is to assess the effectiveness of oral progestin treatment in women diagnosed with complex atypical hyperplasia (CAH) or grade 1 endometrial cancer (G1EC), who desire to preserve their fertility, as alternative treatment to a hysterectomy. METHODS: We reviewed the medical records of women younger than 45 years old that had been diagnosed with CAH or G1EC, who expressed a desire to preserve their fertility using alternative treatment at our institution. Women without evidence of myometrial invasion on pelvic magnetic resonance imaging scans were included. The study period was between 2004 and 2014. Endometrial biopsies were taken at follow-up appointments. RESULTS: We identified 31 young women with CAH or G1EC. The median age was 33 years old (range, 20 to 41), and the median period of time undertaking the treatment was 5 months (range, 1 to 12). Twenty-three patients (74.2%) achieved complete remission (CR; median time to CR was 3 months; range, 1 to 22), 16 patients (88.9%) with CAH and 7 (53.8%) with G1EC achieved CR. 6 patients (26.1%) who had achieved CR, had recurrence of the disease (median time from CR to recurrence was 12.5 months; range, 4 to 18). Eight patients (25.8%) finally underwent a hysterectomy. CONCLUSION: Oral progestin therapy is an alternative treatment for women with CAH or G1EC who desire fertility preservation. However, more prospective studies are needed for standard progestin regimen. Also, there still remains a risk of disease progression and recurrence. Therefore, close follow-up is important during treatment and after CR. In addition, a hysterectomy is recommended as a definitive treatment after completion of childbearing.
Appointments and Schedules ; Biopsy ; Disease Progression ; Endometrial Hyperplasia ; Endometrial Neoplasms* ; Female ; Fertility ; Fertility Preservation ; Follow-Up Studies ; Humans ; Hyperplasia* ; Hysterectomy ; Magnetic Resonance Imaging ; Medical Records ; Mortuary Practice ; Progestins ; Prospective Studies ; Recurrence

OBJECTIVES: The survival rate of all childhood cancers has been increasing, and latent effects on childhood cancer survivors have been gaining researchers' attention. It has been shown that childhood cancer survivors experience social maladaptation and a decreased quality of life. Although neuroblastoma is one of the most common solid cancers in childhood, there are few reports on psychosocial status in neuroblastoma survivors. The purpose of this study was to investigate temporal changes in psychosocial status in neuroblastoma survivors. METHODS: This study was conducted by undertaking retrospective chart reviews of neuroblastoma survivors that were treated between January 1997 and February 2016 at Samsung Medical Center, Seoul, Korea. Among the 54 survivors identified, data for 28 patients who underwent psychological evaluation before and after treatment completion were selected for further analysis. We compared intelligence score, Korea-Child Behavior Checklist (K-CBCL), and Korean Personality Rating Scale for Children (K-PRC) scores before and after treatment completion. Time derivatives for each variable were calculated to identify temporal changes in scores. RESULTS: After treatment completion, K-CBCL scores for total competence (t=−2.34, p=0.044), somatic complaints (t=−2.43, p=0.022), and thought problems (t=−3.03, p=0.006) were higher than the scores prior to treatment. Familial relationship in K-PRC was significantly improved after treatment (t=2.11, p=0.045). Time derivatives of the significant K-CBCL subscales, except for the withdrawal and externalizing symptom scores, showed a tendency to increase with time. CONCLUSION: Although familial relationship and social competence improved after treatment, the levels of somatic complaints and thought problems increased following neuroblastoma treatment.
Checklist ; Child ; Humans ; Intelligence ; Korea ; Mental Competency ; Mortuary Practice ; Neuroblastoma* ; Quality of Life ; Retrospective Studies ; Seoul ; Social Skills ; Survival Rate ; Survivors*