BACKGROUND

Molluscum contagiosum is a benign viral infection affecting children, sexually active adults, and immunocompromised individuals. Modified autoinoculation (MAI) is a procedure in which a solitary lesion of molluscum contagiosum lesion is inoculated in the affected skin to stimulate an immune response, thereby clearing the infection.

This study aimed to compare the efficacy and safety of modified autoinoculation versus curettage in the treatment of molluscum contagiosum infection.

This study was an assessor-blinded, randomized therapeutic trial performed at the Department of Dermatology of Jose R. Reyes Memorial Medical Center. 52 patients with newly diagnosed molluscum contagiosum that had not been previously treated were assigned randomly using computer-generated randomization to either curettage or MAI. 26 patients were allocated in each treatment group. Patients were followed-up every 2 weeks for 3 months and at 6 months to evaluate clearance and recurrence rates along with adverse events.

Curettage was significantly a more effective treatment than MAI in achieving higher clearance rates and reducing recurrences. Adverse events did not differ significantly.

While MAI was a less invasive alternative, curettage remains superior in terms of efficacy and recurrence prevention. However, MAI may still be considered for patients seeking a less painful procedure, especially in children and those with extensive lesions.

Humans ; Child ; Myrtus ; Molluscum Contagiosum/drug therapy* ; Dermatitis, Atopic/drug therapy*

No abstract available.
Epidermal Cyst ; Molluscum Contagiosum

No abstract available.
Heel* ; Molluscum Contagiosum* ; Weight-Bearing* ; Zea mays

Wells' syndrome or eosinophilic cellulitis is usually observed in adults who present with pruritic, erythematous and edematous plaques associated with papules or vesicles. It is a rare inflammatory dermatosis of unknown etiology showing an eosinophil-mediated immune response. Classical histopathological features observed in patients are eosinophil-predominant inflammatory infiltration and marked dermal edema, along with ‘flame figures’. An 11-year-old boy presented with edematous plaques surmounted by vesicles on his abdomen and lower extremities. A month prior to presentation, these skin lesions occurred on other parts of his abdomen; however, they resolved spontaneously within a week. Skin biopsies from the recurrent lesions showed features consistent with Wells' syndrome and a few molluscum bodies in the epidermis. Laboratory tests showed peripheral eosinophilia. We concluded that Wells' syndrome in this young patient was caused by preceding molluscum contagiosum infection.
Abdomen ; Adult ; Biopsy ; Cellulitis ; Child* ; Edema ; Eosinophilia ; Eosinophils ; Epidermis ; Humans ; Lower Extremity ; Male ; Molluscum Contagiosum* ; Skin ; Skin Diseases

No abstract available.
Acquired Immunodeficiency Syndrome ; HIV ; Humans ; Molluscum Contagiosum*

No abstract available.
Adult* ; Humans ; Molluscum Contagiosum*

Eyelid Diseases ; diagnosis ; immunology ; pathology ; Facial Dermatoses ; diagnosis ; immunology ; pathology ; HIV Infections ; complications ; immunology ; Humans ; Immunocompromised Host ; Male ; Middle Aged ; Molluscum Contagiosum ; complications ; diagnosis ; immunology ; pathology

No abstract available.
Molluscum Contagiosum*

PURPOSE: To report the relative frequency and clinical characteristics of patients with benign eyelid tumors. METHODS: A retrospective study of 192 consecutive patients admitted to Korea University Ansan Hospital with benign eyelid tumor between January 2009 and December 2014 was undertaken, and clinical records including age, sex, involved site, and pathology of tumors were reviewed retrospectively. All eyelid tumors were confirmed histopathologically. RESULTS: The sexual distribution revealed 87 males and 105 females with benign eyelid tumors. The mean age at diagnosis was 42.6 +/- 19.2 years. Molluscum contagiosum (5.5 +/- 3.5 years) and pilomatrixoma (14.0 +/- 15.6 years) were generally found in younger individuals, while seborrheic keratosis (60.2 +/- 15.8 years) and squamous cell papilloma (50.5 +/- 13.4 years) occurred predominantly in elderly patients. Tumors were most common on the upper lid (63.0%). The four most frequent subtypes were melanocytic nevus (37.5%), epidermal cyst (8.3%), squamous cell papilloma (5.7%), and seborrheic keratosis (5.2%). CONCLUSIONS: The most common histopathological diagnosis of benign eyelid tumors was melanocytic nevus. The results of this study provide epidemiological information that will be useful for diagnosis and therapy of such tumors.
Aged ; Diagnosis ; Epidermal Cyst ; Eyelids* ; Female ; Gyeonggi-do ; Humans ; Keratosis, Seborrheic ; Korea ; Male ; Molluscum Contagiosum ; Nevus, Pigmented ; Papilloma ; Pathology ; Pilomatrixoma ; Retrospective Studies