Background: Excessive sugar intake is a major global health concern, linked to elevated risks of obesity and various chronic diseases. Taste perception significantly influences dietary behaviors, yet the relationship between salty taste perception and sugar consumption remains underexplored. This study examines whether salty taste perception affects dietary behaviors related to sugar intake. Methods: A total of 139 adults (35 males and 104 females) aged 19 and older participated. Salty taste recognition thresholds and preferences were evaluated using sensory tests involving salt solutions and soup samples with varying salt concentrations. Sugar-related dietary behaviors were assessed through a 10-item questionnaire survey and a semiquantitative food frequency questionnaire consisted of 18 sweet-tasting foods. Results: Younger adults displayed higher sugar-related dietary scores and consumed sweet-tasting foods more frequently than middle- aged participants. While salty taste recognition thresholds showed no significant association, salty taste preferences were positively correlated with sugar-related dietary behaviors. Participants with a stronger salty taste preference exhibited a greater tendency to consume sweetened foods and beverages and preferred sugar-rich foods such as jelly, cakes, and ice cream. These correlations remained significant after adjusting for sex and age, emphasizing the link between salty taste preference and total sugar intake. Male participants consumed sugar-sweetened beverages and sweet dishes, such as bulgogi, more often than females, though no sex differences were found in overall sugar-related dietary scores. Conclusions These findings highlight a close relationship between salty and sweet taste preferences, suggesting that individuals who prefer salty tastes may be more likely to increase their sugar intake. Understanding this interaction can help develop strategies to address excessive sugar consumption and its associated health risks.

Background: Excessive sugar intake is a major global health concern, linked to elevated risks of obesity and various chronic diseases. Taste perception significantly influences dietary behaviors, yet the relationship between salty taste perception and sugar consumption remains underexplored. This study examines whether salty taste perception affects dietary behaviors related to sugar intake. Methods: A total of 139 adults (35 males and 104 females) aged 19 and older participated. Salty taste recognition thresholds and preferences were evaluated using sensory tests involving salt solutions and soup samples with varying salt concentrations. Sugar-related dietary behaviors were assessed through a 10-item questionnaire survey and a semiquantitative food frequency questionnaire consisted of 18 sweet-tasting foods. Results: Younger adults displayed higher sugar-related dietary scores and consumed sweet-tasting foods more frequently than middle- aged participants. While salty taste recognition thresholds showed no significant association, salty taste preferences were positively correlated with sugar-related dietary behaviors. Participants with a stronger salty taste preference exhibited a greater tendency to consume sweetened foods and beverages and preferred sugar-rich foods such as jelly, cakes, and ice cream. These correlations remained significant after adjusting for sex and age, emphasizing the link between salty taste preference and total sugar intake. Male participants consumed sugar-sweetened beverages and sweet dishes, such as bulgogi, more often than females, though no sex differences were found in overall sugar-related dietary scores. Conclusions These findings highlight a close relationship between salty and sweet taste preferences, suggesting that individuals who prefer salty tastes may be more likely to increase their sugar intake. Understanding this interaction can help develop strategies to address excessive sugar consumption and its associated health risks.

Background: Excessive sugar intake is a major global health concern, linked to elevated risks of obesity and various chronic diseases. Taste perception significantly influences dietary behaviors, yet the relationship between salty taste perception and sugar consumption remains underexplored. This study examines whether salty taste perception affects dietary behaviors related to sugar intake. Methods: A total of 139 adults (35 males and 104 females) aged 19 and older participated. Salty taste recognition thresholds and preferences were evaluated using sensory tests involving salt solutions and soup samples with varying salt concentrations. Sugar-related dietary behaviors were assessed through a 10-item questionnaire survey and a semiquantitative food frequency questionnaire consisted of 18 sweet-tasting foods. Results: Younger adults displayed higher sugar-related dietary scores and consumed sweet-tasting foods more frequently than middle- aged participants. While salty taste recognition thresholds showed no significant association, salty taste preferences were positively correlated with sugar-related dietary behaviors. Participants with a stronger salty taste preference exhibited a greater tendency to consume sweetened foods and beverages and preferred sugar-rich foods such as jelly, cakes, and ice cream. These correlations remained significant after adjusting for sex and age, emphasizing the link between salty taste preference and total sugar intake. Male participants consumed sugar-sweetened beverages and sweet dishes, such as bulgogi, more often than females, though no sex differences were found in overall sugar-related dietary scores. Conclusions These findings highlight a close relationship between salty and sweet taste preferences, suggesting that individuals who prefer salty tastes may be more likely to increase their sugar intake. Understanding this interaction can help develop strategies to address excessive sugar consumption and its associated health risks.

Background: Excessive sugar intake is a major global health concern, linked to elevated risks of obesity and various chronic diseases. Taste perception significantly influences dietary behaviors, yet the relationship between salty taste perception and sugar consumption remains underexplored. This study examines whether salty taste perception affects dietary behaviors related to sugar intake. Methods: A total of 139 adults (35 males and 104 females) aged 19 and older participated. Salty taste recognition thresholds and preferences were evaluated using sensory tests involving salt solutions and soup samples with varying salt concentrations. Sugar-related dietary behaviors were assessed through a 10-item questionnaire survey and a semiquantitative food frequency questionnaire consisted of 18 sweet-tasting foods. Results: Younger adults displayed higher sugar-related dietary scores and consumed sweet-tasting foods more frequently than middle- aged participants. While salty taste recognition thresholds showed no significant association, salty taste preferences were positively correlated with sugar-related dietary behaviors. Participants with a stronger salty taste preference exhibited a greater tendency to consume sweetened foods and beverages and preferred sugar-rich foods such as jelly, cakes, and ice cream. These correlations remained significant after adjusting for sex and age, emphasizing the link between salty taste preference and total sugar intake. Male participants consumed sugar-sweetened beverages and sweet dishes, such as bulgogi, more often than females, though no sex differences were found in overall sugar-related dietary scores. Conclusions These findings highlight a close relationship between salty and sweet taste preferences, suggesting that individuals who prefer salty tastes may be more likely to increase their sugar intake. Understanding this interaction can help develop strategies to address excessive sugar consumption and its associated health risks.

Background: and Purpose The prevalence of Alzheimer’s dementia (AD) is increasing as populations age, causing immense suffering for patients, families, and communities. Unfortunately, no treatments for this neurodegenerative disease have been established. Predicting AD is therefore becoming more important, because early diagnosis is the best way to prevent its onset and delay its progression. Methods: Mild cognitive impairment (MCI) is the stage between normal cognition and AD, with large variations in its progression. The disease can be effectively managed by accurately predicting the probability of MCI progressing to AD over several years. In this study we used the Alzheimer’s Disease Neuroimaging Initiative dataset to predict the progression of MCI to AD over a 3-year period from baseline. We developed and compared various recurrent neural network (RNN) models to determine the predictive effectiveness of four neuropsychological (NP) tests and magnetic resonance imaging (MRI) data at baseline. Results: The experimental results confirmed that the Preclinical Alzheimer’s Cognitive Composite score was the most effective of the four NP tests, and that the prediction performance of the NP tests improved over time. Moreover, the gated recurrent unit model exhibited the best performance among the prediction models, with an average area under the receiver operating characteristic curve of 0.916 Conclusions Timely prediction of progression from MCI to AD can be achieved using a series of NP test results and an RNN, both with and without using the baseline MRI data.

Objective: : Isoflurane, a widely used common inhalational anesthetic agent, can induce brain toxicity. The challenge lies in protecting neurologically compromised patients from neurotoxic anesthetics. Choline alfoscerate (L-α-Glycerophosphorylcholine, α-GPC) is recognized for its neuroprotective properties against oxidative stress and inflammation, but its optimal therapeutic window and indications are still under investigation. This study explores the impact of α-GPC on human astrocytes, the most abundant cells in the brain that protect against oxidative stress, under isoflurane exposure. Methods: : This study was designed to examine changes in factors related to isoflurane-induced toxicity following α-GPC administration. Primary human astrocytes were pretreated with varying doses of α-GPC (ranging from 0.1 to 10.0 μM) for 24 hours prior to 2.5% isoflurane exposure. In vitro analysis of cell morphology, water-soluble tetrazolium salt-1 assay, quantitative real-time polymerase chain reaction, proteome profiler array, and transcriptome sequencing were conducted. Results: : A significant morphological damage to human astrocytes was observed in the group that had been pretreated with 10.0 mM of α-GPC and exposed to 2.5% isoflurane. A decrease in cell viability was identified in the group pretreated with 10.0 μM of α-GPC and exposed to 2.5% isoflurane compared to the group exposed only to 2.5% isoflurane. Quantitative real-time polymerase chain reaction revealed that mRNA expression of heme-oxygenase 1 and hypoxia-inducible factor-1α, which were reduced by isoflurane, was further suppressed by 10.0 μM α-GPC pretreatment. The proteome profiler array demonstrated that α-GPC pretreatment influenced a variety of factors associated with apoptosis induced by oxidative stress. Additionally, transcriptome sequencing identified pathways significantly related to changes in isoflurane-induced toxicity caused by α-GPC pretreatment. Conclusion : The findings suggest that α-GPC pretreatment could potentially enhance the vulnerability of primary human astrocytes to isoflurane-induced toxicity by diminishing the expression of antioxidant factors, potentially leading to amplified cell damage.

Humans ; Adult ; Cigarette Smoking/epidemiology* ; Prevalence ; Electronic Nicotine Delivery Systems ; Tobacco Products ; Republic of Korea/epidemiology*

Till date, researchers have been developing animal models of Alzheimer’s disease (AD) in various species to understand the pathological characterization and molecular mechanistic pathways associated with this condition in humans to identify potential therapeutic treatments. A widely recognized AD model that mimics the pathology of human AD involves the intracerebroventricular (ICV) injection with streptozotocin (STZ).However, ICV injection as an invasive approach has several limitations related to complicated surgical procedures. Therefore, in the present study, we created a customized stereotaxic frame using the XperCT-guided system for injecting STZ in cynomolgus monkeys, aiming to establish an AD model. The anatomical structures surrounding the cisterna magna (CM) were confirmed using CT/MRI fusion images of monkey brain with XperCT, the c-arm cone beam computed tomography. XperCT was used to determine the appropriate direction in which the needle tip should be inserted within the CM region. Cerebrospinal fluid (CSF) was collected to confirm the accurate target site when STZ was injected into the CM.Cynomolgus monkeys were administered STZ dissolved in artificial CSF once every week for 4 weeks via intracisterna magna (ICM) injection using XperCT-guided stereotactic system. The molecular mechanisms underlying the progression of STZ-induced AD pathology were analyzed two weeks after the final injection. The monkeys subjected to XperCT-based STZ injection via the ICM route showed features of AD pathology, including markedly enhanced neuronal loss, synaptic impairment, and tau phosphorylation in the hippocampus. These findings suggest a new approach for the construction of neurodegenerative disease models and development of therapeutic strategies.