Objective:To develop an improved wireless intelligent capsule cystoscope (WCE)for dynamic detection of bladder mucosa in a pig model.Methods:The WCE was introduced into a healthy experimental pig that under general anesthesia via urethra by applying an improved device. Multi-angle images of the bladder mucosa were then obtained by controlling the position of capsule cystoscope with an external magnetic field system. The shutter speed of the WCE was 2.5 fps and was automatically converted to 1.5 fps 30 minutes after initiation. The Vue software was utilized to download the shoot pictures which were former received by a computer via wireless transmission. The pig was roused and sent to the pigpen, without limitations in moving. The improved WCE was connected with a 2 cm thread. 12 hours later, the dilated sheath was inserted again, and the capsule was removed by a foreign body forceps under observation of a ureteroscopy.Results:The WCE was successfully placed and removed from the pig's bladder with the application of the improved devices. Over 20 thousand images that with 60K pixels of bladder mucosa were captured by the WCE at various angles within 12 hours, which revealed the process of urine filling and excreting in a time-dependent way. No notable adverse effects (bleeding, urinary tract injury, etc) were noted during the process of cystoscope placement, image acquisition, transmission, and removal.Conclusion:This study developed a novel WCE that could dynamically, intelligently and accurately monitor all aspects of the pig bladder mucosa, and has preferable application prospect.

Patient safety is the cornerstone of medical quality and an important foundation for a healthy China.In May 2023,the National Health Commission and the National Administration of Traditional Chinese Medicine jointly is-suedthe Action Plan for Comprehensively Improving Medical Quality(2023-2025),which identified patient safety as an important task and special action.It introduces the concept of patient safety,the status quo of patient safety ac-tions at home and abroad,and the research trend of patient safety,and compares the work requirements of patient safety management and special actions in the Action Plan for Comprehensively Improving Medical Quality(2023-2025),and finally puts forward a series of suggestions for formulating the Implementation Plan of Special Ac-tions for Patient Safetywith Chinese characteristics.

This article reviews the overview of digital integration of geriatric patients and related influencing factors, the current situation of smart outpatient service, and the aging measures of smart outpatient service, with a view to providing reference for Chinese scholars to further study digital integration of geriatric patients.

"Westward Migration Spirit" is the precious spiritual wealth of Chinese Communist Party and the Chinese nation. The course teaching team takes the undergraduate students of clinical medicine as the teaching object, tries to integrate the "Westward Migration Spirit" into the cultivation of medical students’ medical professionalism, so as to endow new connotation of medical professionalism and promote the improvement of medical students’ professionalism. Through literature review, expert consultation and questionnaire survey, the paper sorted out the context of "Westward Migration Spirit" of Chongqing Medical University, and typical examples with the spirit of medical science and humanity were selected and integrated into the teaching. A questionnaire was designed to investigate the evaluation of 425 clinical medicine undergraduates and 5 teachers on the medical professionalism course integrated with "Westward Migration Spirit" . The results show that the students and teachers have good feedback to the medical professionalism courses integrated with the "Westward Migration Spirit" , and the course has a significant positive effect on the cultivation of medical students’ medical professionalism.

Complex adaptive system theory provides an interdisciplinary perspective for people to understand modern complex medical systems.This study introduces the background of complex adaptive system theory, basic viewpoints, demonstration of complex attributes of nursing, its application in the nursing field and analysis and evaluation of the theory, in order to provide new theoretical methods and ideas for the clinical practice and research of nursing scholars in China.

Objective:To compare the research status of smart aged care platforms at home and abroad by bibliometrics, so as to provide a reference for the smart transformation of Chinese industry of health care for the aged from a macro level.Methods:Web of Science core collection and China National Knowledge Infrastructure (CNKI) were taken as sources to analyze the research progress at home and abroad from 2010 to 2020. The analysis function of the database, VOSviewer and CiteSpace were used to quantitatively analyze and visualize the research situation and hotspots of the smart aged care platform, and perform a qualitative analysis of the included literature.Results:Totally, 166 articles in English and 78 articles in Chinese were included. The annual number of papers published at home and abroad showed an overall growth trend, and the research field involved multiple disciplines. The keywords that appeared frequently in the research on foreign smart medical care platforms were "assistive technology""elderly""smart home""e-health""telecare", and "rehabilitation". The top five keywords in the ranking of the number of occurrences in China were "smart elderly care""Internet of things""smart home""Internet +" and "combined medical care". Foreign research had become in-depth and diverse in the four aspects of platform technology preparation, functions, privacy and data protection, and effect evaluation.Conclusions:The development of academic research on the smart aged care platform and its related technologies is steady and diverse. However, compared with foreign countries, there is still a certain gap in content and technology in China. It is necessary to learn from foreign excellent technologies and concepts on the basis of conforming to national conditions to promote the further development of smart medical care platforms.

Objective:To explore the teaching effect of case-based learning (CBL) in patient safety course.Methods:A self-made CBL teaching effect questionnaire was used to conduct an online survey on 212 clinical medical undergraduates from a medical college in Chongqing.Results:A total of 212 questionnaires were collected, with 100% of effective recovery rate. Among the students, 91.0% believed that CBL teaching quality was high; 92.4% were satisfied with CBL teaching; 62.7% were the first to experience CBL teaching; 96.7% preferred CBL teaching; 94.3% said that in the future teaching, they would like to accept CBL Teaching. Most students thought that CBL played a vital role in stimulating learning interest, improving learning enthusiasm, activating classroom atmosphere, broadening learning ideas, exercising independent thinking ability, and facilitating the ability of theory connected with practice. Suggestions for the CBL teaching of patient safety courses are summarized into the following three keywords: multiple cases, more interactions, and more similar teaching.Conclusion:The application of CBL in the patient safety course is worth promoting, which is conducive to improving the teaching quality.

Objective:To explore the application effect of project management in volunteer nursing service activities.Methods:In April 2019, Nursing Department of the First Affiliated Hospital of Chongqing Medical University used the method of project management to establish a special management team, coordinate design, formulate plans and implement special training. Nursing Department also analyzed the reporting rate and activity types of the project over the past 5 months of continuous operation, and adopted the Volunteer Activity Liaison Officer's Perception and Attitude Towards Volunteer Nursing Service Activities Questionnaire to evaluate the application effect.Results:From April to August 2019, a total of 49 volunteer activities were reported with an average of 9.8 times per month; the type of activity was mainly free consultation and nursing assistance, accounting for 30.61% and 26.53% respectively. Scores of volunteer liaison officer's perception and attitude towards volunteer nursing service activities were all in relatively high levels.Conclusions:The project management method can effectively increase the reporting rate of voluntary nursing service activities and promote the effective development of voluntary activities.

Objective To investigate the effect ofpcDNA3.1 (+)/VEGF165 plasmid transfection on endothelial progenitor cells (EPCs)derived from murine bone marrow mediated by liposome.Methods EPCs were isolated from murine bone marrow cuhured in vitro,identified by immunocytochemistry and fluorescence-activated cell sorting.After transfection,VEGF165 mRNA in EPCs was detected by reverse transcription polymerase chain reaction (RT-PCR),and VEGF protein in the culture supernatant of EPCs was detected by enzyme-linked immunosorbent assay (ELISA).MTT method was used to study the effect of transfection by pcDNA3.1 (+)/VEGF165 plasmid on EPCs.Results EPCs expressed cell markers CD34,CD133,KDR.Gel electrophoresis showed that a 576bp product was amplified by RT-PCR in VEGF165-transfected cells,while a weak expression of VEGF165 was observed in mock-transfected and non-transfected cells.The protein level of VEGF165 in the supernatant of VEGF165-transfected was higher than that in the other groups.VEGF165 plasmid transfer could stimulate EPCs proliferation.Conclusion EPCs can successfully transfect VEGF165 gene and promote the proliferation of EPCs,providing experimental basis for treatment of erectile dysfunction.

Objective To compare the efficacy of extended pelvic lymph node dissection (ePLND)and oncological outcome by fluorescence laparoscopic radical prostatectomy (FLRP) versus high-definition laparoscopic radical prostatectomy (HD-LRP) for men with locally advanced prostate cancer (LAPCa).Methods In a prospective trial,we recruited 51 patients with T3a-bNxM0 prostate cancer from July 2015 to April 2018.Patients were assigned to study group or control group according to random number method,and were underwent either FLRP + ePLND or HD-LRP + ePLND.21 in the study group were injected with 5 mg of indocyanine green (ICG) into the bilateral lobes of the prostate transperineally guiled by transrectal ultrasound 30 min before surgery for lymphography.During the surgical procedure a fluorescence laparoscope,optimized for detection in the near infrared range,was used to visualize the lymph nodes (green fluorescent) in the dissection region in the study group while a common laparoscopy introduced in control one.Lymph nodes were removed in the external iliac vessiles,internal iliac artery,obturator fossa regions,common iliac regions and presacral regions in both groups.Radical prostatectomy was completed in the both groups by similar steps.The operation time,blood loss,number of removed lymph nodes and positive lymph nodes,complication rate,biochemical recurrence (BCR) and metastasis free survival rates in 2 years were recorded and compared in the two groups.Results 51 eligible patients were selected,including 21 in the study group and 30 in the control group.The mean age of biopsy of study group and control one were (66.4 ± 7.7) and (66.8 ± 7.4),the mean age PSA (23.5 ± 16.8) ng/ml and (26.0 ± 20.1) ng/ml,the mean Gleason score of biopsy (8.1 ± 1.0) and (7.9 ± 0.9) respectively,and there was no statistical significant difference between two groups.The mean operation time of study group and control one were (45.9 ± 4.6) min and (56.4 ± 3.2) min,the mean removed lymph nodes were (27.7 ± 5.6) and (22.1 ±5.6) respectively,and there was statistical significant difference between two groups (all P ＜ 0.05).Lymph nodes invasion in pathology were reported in 8 cases(38.1％)in the study groups while 9 (30.0 ％) in the control one;the proportion of positive lymph node (metastasis) were 3.2％ (19/583) and 3.4％ (23/663) in the two groups respectively and no statistically significant difference was noted between the two groups.Lymphorrhagia occurred in 4 cases in the control group,and there was no serious complications in both groups.The median follow-up time was 20 (7-33) month and during this time,BCR observed of 1 (4.7％) in the study group and 8 (26.7％) in the control;meanwhile,the MFSR was recorded of 100.0％ (0)in the study group and 86.7％ (4)in the control one,showing a statistically significant difference between the two groups(P =0.04).Conclusions Comparing with LRP,FLRP achieved better results of LN dissection,which will improve oncological outcomes.