2.Melanoma in Singapore: A 20-year review of disease and treatment outcomes.
Pei Ming YEO ; Ziying Vanessa LIM ; Wei Ding Virlynn TAN ; Xiahong ZHAO ; Hui Yi CHIA ; Suat Hoon TAN ; Melissa Ching Ching TEO ; Melissa Wee Ping TAN
Annals of the Academy of Medicine, Singapore 2021;50(6):456-466
		                        		
		                        			INTRODUCTION:
		                        			Melanomas in Asians have different clinicopathological characteristics and prognosis from melanomas in Caucasians. This study reviewed the epidemiology and treatment outcomes of cutaneous melanoma diagnosed at a tertiary referral dermatology centre in Singapore, which has a multiracial population. The study also determined whether Asians had comparable relapse-free and overall survival periods to Caucasians in Singapore.
		                        		
		                        			METHOD:
		                        			This is a retrospective review of cutaneous melanoma cases in our centre between 1996 and 2015.
		                        		
		                        			RESULTS:
		                        			Sixty-two cases of melanoma were diagnosed in 61 patients: 72.6% occurred in Chinese, 19.4% in Caucasians and 3.2% in Indians, with an over-representation of Caucasians. Superficial spreading melanoma, acral lentiginous melanoma and nodular melanoma comprised 37.1%, 35.5% and 22.6% of the cases, respectively. The median time interval to diagnosis was longer in Asians than Caucasians; median Breslow's thickness in Asians were significantly thicker than in Caucasians (2.6mm versus 0.9mm, 
		                        		
		                        			CONCLUSION
		                        			More physician and patient education on skin cancer awareness is needed in our Asian-predominant population for better outcomes.
		                        		
		                        		
		                        		
		                        			Humans
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		                        			Melanoma/therapy*
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		                        			Prognosis
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		                        			Retrospective Studies
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		                        			Singapore/epidemiology*
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		                        			Skin Neoplasms/therapy*
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		                        			Treatment Outcome
		                        			
		                        		
		                        	
            
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