1.Impact of COVID-19 Infection on Work Functioning in Japanese Workers: A Prospective Cohort Study
Makoto OKAWARA ; Keiki HIRASHIMA ; Yu IGARASHI ; Kosuke MAFUNE ; Keiji MURAMATSU ; Tomohisa NAGATA ; Mayumi TSUJI ; Akira OGAMI ; Yoshihisa FUJINO ; For the CORoNaWork Project
Safety and Health at Work 2023;14(4):445-450
		                        		
		                        			 Background:
		                        			The impact of COVID-19 infection on workers' work function persists even after the acute phase of the infection. We studied this phenomenon in Japanese workers. 
		                        		
		                        			Methods:
		                        			We conducted a one-year prospective cohort study online, starting with a baseline survey in December 2020. We tracked workers without baseline work functioning impairment and incorporated data from 14,421 eligible individuals into the analysis. We estimated the incidence rate ratio for new onset of work functioning impairment due to COVID-19 infection during follow-up, using mixed-effects Poisson regression analysis with robust variance. 
		                        		
		                        			Results:
		                        			Participants reporting infection between January and December 2021 showed a significantly higher incidence of new work functioning impairment (adjusted incidence rate ratio: 2.18, 95% confidence interval: 1.75–2.71, p < 0.001). The formality of the recuperation environment correlated with a higher risk of work functioning deterioration in infected individuals (p for trend <0.001). 
		                        		
		                        			Conclusion
		                        			COVID-19-infected workers may continue to experience work difficulties due to persistent, post-acute infection symptoms. Companies and society must urgently provide rehabilitation and social support for people with persistent symptoms, recognizing that COVID-19 is not just a transient acute infection. 
		                        		
		                        		
		                        		
		                        	
2.Sublingual Immunotherapy for Japanese Cedar Pollinosis Attenuates Asthma Exacerbation
Sayaka KIKKAWA ; Kazuyuki NAKAGOME ; Takehito KOBAYASHI ; Tomoyuki SOMA ; Atsushi KAMIJO ; Makoto NAGATA
Allergy, Asthma & Immunology Research 2019;11(3):438-440
		                        		
		                        			
		                        			No abstract available.
		                        		
		                        		
		                        		
		                        			Asian Continental Ancestry Group
		                        			;
		                        		
		                        			Asthma
		                        			;
		                        		
		                        			Cryptomeria
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Rhinitis, Allergic, Seasonal
		                        			;
		                        		
		                        			Sublingual Immunotherapy
		                        			
		                        		
		                        	
4.Case Reports of Polymyalgia Rheumatica Successfully Treated with Kampo Medicines
Hiroaki HIKIAMI ; Naotoshi SHIBAHARA ; Masafumi MURAI ; Yutaka NAGATA ; Hiroki INOUE ; Kiyotaka YAGI ; Makoto FUJIMOTO ; Hirozo GOTO ; Yutaka SHIMADA
Kampo Medicine 2010;61(5):699-707
		                        		
		                        			
		                        			We report 5 patients with polymyalgia rheumatica (PMR) successfully treated with Kampo medicines. In total, we investigated 10 patients with PMR, including the 5 patients here treated in our department. Results showed that Kampo medicine was effective in 6 cases. One of the 6 refused steroid drug administration, and tapering dosage steroid was difficult in the other 5 patients due to myalgia or inflammation. Except for one case, C-reactive protein in most of the effective cases was below 3.0 mg/dl. On the other hand, the non-effective cases had severe inflammation levels and needed steroid therapy. The effective cases were treated with sokeikakketsuto, tokakujokito, keishibukuryogan, choyotokasyakuyaku, yokuibushihaishosan and tokishakuyakusan, which have the effect of improving oketsu states. Thus, it was considered that Kampo medicine has the potential for treatments in PMR patients who have difficulty tapering steroid dosage and mild inflammation. Moreover, this suggests Kampo medicines that improve oketsu state are useful for PMR treatment.
		                        		
		                        		
		                        		
		                        	
5.Trial of the Treatment of Kampo Medicines for Thalamic Pain
Hirozo GOTO ; Makoto FUJIMOTO ; Tetsuro WATANABE ; Hiroaki HIKIAMI ; Ryosuke OBI ; Tatsuya NOGAMI ; Yutaka NAGATA ; Naotoshi SHIBAHARA ; Yutaka SHIMADA
Kampo Medicine 2010;61(2):189-197
		                        		
		                        			
		                        			Thalamic pain is known as intractable central pain caused by thalamic bleeding and infarction. Although some physical and surgical therapies have been tried, there is no established method for its improvement. We attempted the treatment of 6 cases of thalamic pain, and 4 of them showed improvements in their symptoms. Our patients were aged 27-70 years, 4 men and 2 women. Their diagnoses were 3 cases of right thalamic bleedings, 1case of left thalamic bleeding, and 2 cases of right thalamic infarctions. The periods from onset to consulting our department were from6months to 12 years. In the 4 cases whose symptoms improved, the symptoms had almost disappeared or were decreased by at least 40%. These improved cases used formulas containing uzu or bushi. Yokukansankachimpihange was effective for two cases with mental disturbances. One case showing major improvement was treated by only the formula against oketsu. The cases whose symptoms had continued for a long time were more intractable, with the symptoms remaining to some degree in spite of their decreasing tendency. Finally, in intractable cases, their symptoms remained fixed and they had severe paralysis.
		                        		
		                        		
		                        		
		                        	
6.Two Cases of Water Polo Athletes Successfully Treated with the Acupuncture and Moxibustion Therapy
Mari KIMURA ; Naotoshi SHIBAHARA ; Masaki TSUDA ; Yutaka NAGATA ; Makoto FUJIMOTO ; Ryosuke OBI ; Hiroaki HIKIAMI ; Hirozo GOTO ; Yutaka SHIMADA
Kampo Medicine 2009;60(6):623-628
		                        		
		                        			
		                        			Recently, the number of athletes who receive acupuncture therapy is increasing. However, most of these athletes receive acupuncture therapy with single-acupuncture and/or electro-acupuncture to a local point, or a trigger point. We experienced two water polo athletes who were improved using acupuncture and moxibustion therapy with “zuisho” therapy. Case 1 was 16 year old man. He became aware of pain in his right thumb after training, which continued with extended training time, a numbness in his left hand appeared more, and he received acupuncture and moxibustion therapy. These symptoms disappeared immediately with acupuncture and moxibustion therapy using the standard traditional methods, such as contact needling to a yuan point, and in situ acupuncture to a back shu point, etc. Case 2 was 17 year old man. He received acupuncture and moxibustion therapy for lumbago and stiffness of the neck. These symptoms disappeared immediately after acupuncture and moxibustion therapy using the standard traditional methods such as contact needling to a yuan point, and inserting needles into a back shu point, an extra meridian, etc. In these two cases, symptoms were improved with “zuisho” therapy, and both could continue with longer and more strenuous training. This suggests that acupuncture and moxibustion therapy using the standard traditional methods are useful for athletes.
		                        		
		                        		
		                        		
		                        			Acupuncture
		                        			;
		                        		
		                        			 Therapeutic procedure
		                        			;
		                        		
		                        			 symptoms <1>
		                        			;
		                        		
		                        			 Training
		                        			;
		                        		
		                        			 Water
		                        			
		                        		
		                        	
7.Effects of Spa Therapy for Asthmatics with a Long History of Cigarette Smoking, Evaluated by Bronchial Hyperresponsiveness and Generation of Leukotrienes by Leucocytes
Fumihiro MITSUNOBU ; Yasuhiro HOSAKI ; Kozo ASHIDA ; Naofumi IWAGAKI ; Takuya NAGATA ; Makoto FUJII ; Shingo TAKATA ; Masanori HAMADA ; Yoshiro TANIZAKI
The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine 2005;68(2):83-91
		                        		
		                        			
		                        			The effects of spa therapy for asthmatics with a long history of cigarette smoking were studied, compared with the effects for those without smoking history. 1. Of 22 patients with smoking history, 15 (68.2%) had definite efficacy of spa therapy (4 had marked efficacy, and 11 had moderate efficacy), and the residual 7 had slight or no efficacy. In contrast, of 36 patients without smoking history, 29 (80.6%) had definite efficacy. The effects of spa therapy for asthmatics were significantly higher in never-smokers than in ex-smokers.
2. A significant increase in the production of IgE antibodies, bronchial hyperresponsiveness and the generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leucocytes was observed in ex-smokers compared with never-smokers. 3. The frequency of patients with a positive BAST against inhalant allergens was larger in subjects with slight or no efficacy than in those with marked or moderate efficacy in never-smokers, but not in ex-smokers. 4. Bronchial hyperresponsiveness was significantly increased in patients with slight or no efficacy than in those with marked or moderate efficacy both in ex-smokers and never-smoker. 5. The generation of LTB4 was more increased in subjects with slight or no efficacy than in those with efficacy both in ex-smokers and never-smokers, however, the differences were not significant. 5. The generation of LTC4 tended to be more increased in subjects with slight or no efficacy than in those with efficacy in never-smokers, but not in ex-smokers, although these were not significant. The results suggest that an increase in the production of IgE antibodies, bronchial hyperresponsiveness, and the generation of LTB4 and LTC4, which might be influenced by cigarette smoking, affect the effects of spa therapy for patients with asthma.
		                        		
		                        		
		                        		
		                        	
8.Five-year Observation of the Effects of Spa Therapy for Patients with Pulmonary Emphysema, Evaluated by %Low Attenuation Area (%LAA) of the Lungs on High-resolution CT, %DLco and %Residual Volume (RV)
Fumihiro MITSUNOBU ; Yasuhiro HOSAKI ; Kozo ASHIDA ; Naofuni IWAGAKI ; Takuya NAGATA ; Makoto FUJII ; Shingo TAKATA ; Masanori Hamada ; Yoshiro TANIZAKI
The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine 2004;67(3):148-154
		                        		
		                        			
		                        			The effects of long-term spa therapy were studied in 10 patients with pulmonary emphysema: five patients had long-term spa therapy for 5 years (group A), and another 5 patients had not spa therapy for the same 5 years (group B). There were no significant differences in %FVC, %FEV 1.0, %LAA of the lung on HRCT, %DLco and %RV between the two groups. 1. The LAA of the lung on HRCT slightly, but did not significantly increase in patients with spa therapy for 5 years. In patients without spa therapy, the %LAA of the lung significantly increased after 4-(61.1%) (p<0.01) and 5-year observation (65.5%) (p<0.001) compared with the initial value (52.2%). 2. The %DLco and %RV values slightly decreased in patients with spa therapy, but the decrease in the two parameters was not significant. 3. The %DLco significantly decreased (67.2% to 49.0%), and the %RV also significantly increased (175.4% to 230.6%) after 5-year observation in patients without spa therapy. The results obtained here suggest that spa therapy for pulmonary emphysema should start as early as possible when the diagnosis of the disease is decided, and the therapy should be continued as long as possible.
		                        		
		                        		
		                        		
		                        	
9.Improvement of Hyperinflation of the Lungs by Spa Therapy in Patients with Asthma
Fumihiro MITSUNOBU ; Yasuhiro HOSAKI ; Kozo ASHIDA ; Naofumi IWAGAKI ; Takuya NAGATA ; Makoto FUJII ; Shingo TAKATA ; Masanori HAMADA ; Yoshiro TANIZAKI
The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine 2004;67(4):195-201
		                        		
		                        			
		                        			Effects of spa therapy on % low attenuation area (LAA)<-950 HU of the lungs on HRCT at full inspiration, CT number, a ratio of expiratory LAA to inspiratory LAA (exp LAA/ins LAA), residual volume (RV) and diffusing capacity for carbon monoxide (DLco) in asthma were compared between never-smokers and ex-smokers of asthmatics.
1. The % LAA of the lungs on HRCT in asthma significantly decreased after spa therapy both in never-smokers and ex-smokers of asthmatics. CT number also significantly increased in the two groups. 2. The exp LAA/ins LAA significantly decreased after spa therapy in never-smokers, but not in ex-smokers. 3. The %RV also significantly decreased by spa therapy in never-smokers, but not in ex-smokers. 4. The DLco value did not significantly change by spa therapy both in nevers-mokers and ex-smokers. 5. The values of %FVC and %FEV 1.0 tended to increased in the two groups, but the increase was not significant. The value of FEV 1.0% significantly increased after spa therapy in never-smokers, but not in ex-smokers. The results suggest that hyperinflation and destruction of terminal airspaces are stronger in ex-smokers than in never-smokers, and that spa therapy is more effective in never-smokers than in ex-smokers.
		                        		
		                        		
		                        		
		                        	
10.Decrease in Low Attenuation Area(LAA) of the Lungs on High Resolution Computed Tomography(HRCT) by Long-term Spa Therapy in Patients with Asthma.
Kozo ASHIDA ; Fumihiro MITSUNOBU ; Yasuhiro HOSAKI ; Hiroshi TSUGENO ; Makoto OKAMOTO ; Norikazu NISHIDA ; Takuya NAGATA ; Shingo TAKATA ; Tadashi YOKOI ; Yoshiro TANIZAKI
The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine 2003;66(2):115-122
		                        		
		                        			
		                        			Characteristics of low attenuation area (LAA) of the lungs on HRCT were studied in 132 patients with asthma, and long-term spa therapy on the LAA of the lungs was observed in 5 patients with asthma, whose me an %LAA was more than 30%.
1. The morphology of LAA of the lungs on HRCT observed in asthma was different from that in pulmonary emphysema. 2. The LAA of the lungs in asthma was closely related to residual volume (RV). 3. The mean %LAA value significantly decreased from 33.5% before spa therapy to 24.5% at 24 months after beginning of the therapy. CT number also significantly increased after long-term spa therapy. 4. %FEV1.0 value significantly improved from 52.1% before spa therapy to 72.1% at 24 months after spa therapy. The RV value also decreased by spa therapy, however, the decrease was not significant. These results suggest that LAA of the lungs in asthma is associated with hyperinflation, and the LAA of the lungs decreases after long-term spa therapy.
		                        		
		                        		
		                        		
		                        	
            

Result Analysis
Print
Save
E-mail