This case report presents a closed hollow bulb obturator made by 3D printing for a maxillectomy patient. Final impression was taken according to the instructions and impression trays provided by the Magic denture™ system. Vertical dimension, facial appearance, and retention had been checked with the try-in denture. The try-in denture was corrected and adjusted to fulfill the demand of the patients, then these were reflected to the final design of the denture. The defect area was designed as a closed hollow bulb shape to reduce the weight and to provide uniform thickness of the denture. The patient satisfied with the esthetics and function of the denture.
Clothing ; Dentures ; Esthetics ; Humans ; Magic ; Printing, Three-Dimensional ; Rehabilitation ; Vertical Dimension

PURPOSE: This study was conducted to describe the development and validation of the Hocus Focus Magic Performance Evaluation Scale (HFMPES), which is used to evaluate the competency of health professions personnel in delivering magic tricks as a therapeutic modality. METHODS: A 2-phase validation process was used. Phase I (content validation) involved 16 magician judges who independently rated the relevance of each of the 5 items in the HFMPES and established the veracity of its content. Phase II evaluated the psychometric properties of the HFMPES. This process involved 2 magicians using the HFMPES to independently evaluate 73 occupational therapy graduate students demonstrating 3 magic tricks. RESULTS: The HFMPES achieved an excellent scale-content validity index of 0.99. Exploratory factor analysis of the HFMPES scores revealed 1 distinct factor with alpha coefficients ≥0.8 across the 3 magic tricks. The construct validity of the HFMPES scores was further supported by evidence from a known-groups analysis, in which the Mann–Whitney U-test showed significant difference in HFMPES scores between participants with different levels of experience in delivering the 3 magic tricks. The inter-rater reliability coefficients were ≥0.75 across the 3 magic tricks, indicating that the competency of health professions personnel in delivering the 3 magic tricks could be evaluated precisely. CONCLUSION: Preliminary evidence supported the content and construct validity of the HFMPES, which was found to have good internal consistency and inter-rater reliability in evaluating health professions personnel's competency in delivering magic tricks.
Complementary Therapies ; Health Occupations ; Humans ; Magic ; Occupational Therapy ; Psychometrics ; Reproducibility of Results ; United States

OBJECTIVE: Biased attribution styles of assigning hostile intention to innocent others and placing the blame were found in schizophrenia. Attribution styles in individuals at ultra-high risk (UHR) for psychosis, however, have been less studied especially for its association with various psychological factors. We investigated whether UHR individuals show increased hostility perception and blaming bias and explored the associations of these biased styles of attribution with the factor structure of multifaceted self-related psychological variables and neurocognitive performances. METHODS: Fifty-four UHR individuals and 80 healthy controls were assessed by evaluating resilience, self-perception, self-esteem, and aberrant subjective experiences of schizotypy (physical anhedonia, social anhedonia, magical ideation, and perceptual aberration), basic symptoms, and carrying out a comprehensive neurocognitive test battery. Attribution styles were assessed using the Ambiguous Intentions Hostility Questionnaire. RESULTS: UHR individuals, compared with normal controls, showed increased hostility perception and blaming bias. Factor analysis of self-related psychological variables and neurocognitive performances in the entire subject population showed a three-factor solution, which was designated as reflective self, pre-reflective self, and neurocognition. Multiple regression analysis in UHR individuals revealed that hostility perception bias was associated with reflective self and composite blame bias was associated with reflective and pre-reflective self. CONCLUSION: This study supports the emergence of attribution biases in the putative ‘prodromal’ phase of schizophrenia. The associations of biased attribution styles with multifaceted self-related psychological constructs suggest that psychosocial interventions for biased attribution styles in UHR individuals should focus not only on reflective self but also pre-reflective self-related psychological constructs.
Anhedonia ; Bias (Epidemiology)* ; Hostility ; Intention ; Magic ; Psychology ; Psychotic Disorders* ; Schizophrenia ; Self Concept

OBJECTIVES: Magical ideation refers to belief in forms of causation that by conventional standards are invalid, and is considered to be one of prodromal psychotic symptoms in schizophrenia. This study aimed to investigate the relationship between magical ideation and eye gaze pattern in patients with schizophrenia. METHODS: Eye gaze data were recorded in 23 patients with schizophrenia and 23 healthy controls while performing the reality evaluation task, in which participants should judge the realness of real or unreal pictures. RESULTS: Compared to healthy controls, patients with schizophrenia showed decreased fixation, saccade and area of interest (AOI) fixation counts, and reduced scanpath length. Magical Ideation Scale score in patients with schizophrenia showed negative correlation with the scanpath length in the real condition and the AOI fixation count in the unreal condition. CONCLUSION: These findings suggest that patients with schizophrenia show restricted visual scanning during reality evaluation, and their restricted visual scanning may play an important role in the magical ideation.
Humans ; Magic ; Saccades ; Schizophrenia

Nowadays antibiotic resistance is a worldwide serious problem that mainly affects public health. Omadacycline is a unique antibiotic which has two available dosage forms such as intravenous (IV) and oral that development for community-acquired bacterial infectious disease treatment. It is a modified form of older tetracycline at C-9 aminomethyl substituent of 6-member core ring of tetracycline. Modification form shows its activity against efflux pump and ribosomal protein protection mechanism of tetracycline resistance. Generally, omadacycline is effective against methicillin-resistant S. aureus (MRSA), Streptococcus pneumoniae, vancomycin-resistant Enterococcus (VRE), Legionella and Chlamydia spp. Efficacy, safety and tolerability profile of omadacycline those compares with recent antibiotics shows that omadacycline is less resistant than others. One derivative from tetracycline derivatives is 9-neopentylaminomethylminocycline called omadacycline was discovered and ongoing phase III clinical experiments as a therapy for acute bacterial skin and skin structure infections (ABSSSI) as well as community-acquired bacterial pneumonia (CABP). Omadacycline seems to be a strong drug candidate for future promising new antibacterial agent that is effective against ABSSSI and CABP.
Anti-Bacterial Agents* ; Bacterial Infections* ; Chlamydia ; Communicable Diseases ; Dosage Forms ; Drug Resistance, Microbial ; Enterococcus ; Legionella ; Magic* ; Methicillin Resistance ; Pneumonia, Bacterial ; Public Health ; Ribosomal Proteins ; Skin ; Streptococcus pneumoniae ; Tetracycline ; Tetracycline Resistance

Because the perception of infertility in medieval Europe ranged from the extremely religious view of it as a malediction of God or the devil's work, to the reasonable medical conception of it as a sort of disease to treat, it is very difficult to determine the general attitudes of ordinary people towards infertility. This article seeks to elucidate the common social perception of infertility and its treatment in late medieval Europe by analyzing the case of Margherita Datini, an Italian merchant's wife who lived in the 1400s. It relies heavily on the documents left by her and her husband, Francesco Datini; the couple left many records, including letters of correspondence between them. Margherita and those around her regarded infertility not as the devil's curse or a punishment by God but as a disease that can be cured. Margherita and her husband, Francesco, tried hard to cure their infertility. They received treatment and prescriptions from several doctors while also relying on folk remedies, religious therapies, and even magical remedies. The comparative analysis of Datini documents, medical books, and theoretical treatises or prescriptive essays by clerics suggests that the general perception of infertility in medieval Europe was located between the extremely religious and modern medical conceptions of it.
Clergy ; Europe ; Fertilization ; Humans ; Infertility* ; Italy* ; Magic ; Medicine, Traditional ; Prescriptions ; Punishment ; Social Perception* ; Spouses*

OBJECTIVE: To analyze subregional differences in T1rho (T1ρ) and T2 values and their correlation in asymptomatic knee cartilage, and to evaluate angular dependence with magic angles. MATERIALS AND METHODS: Six asymptomatic volunteers underwent knee MRI with T1ρ and T2 mapping. T1ρ and T2 values were measured by two radiologists independently, at nine subregions in the medial femoral condyle (MFC) cartilage, at angles of ± 0°, 15°, 35°, 55°, 75° respective to a vertical line (B0) bisecting the width of the distal femur, and at two locations in the patella. Subregional values of T1ρ and T2 were analyzed and significant differences in three divided portions of the MFC (anterior, central, and posterior) were statistically evaluated. Correlation between T1ρ and T2 and angular dependence with magic angles were also assessed for statistical significance. RESULTS: T1ρ values were lowest at +15° and highest at -55°. T2 values were lowest at +75° and highest at +35°. Both T1ρ and T2 were higher in superior patella than inferior patella. T1ρ showed significant differences in the three divided portions of the MFC, while T2 showed significant differences only between central and posterior portions. There was a weak correlation between T1ρ and T2 (r = 0.217, p = 0.127). T1ρ showed more angular dependence than T2. CONCLUSION: T1ρ and T2 showed different subregional values and angular dependence in asymptomatic knee cartilage with a weak correlation. Awareness of these differences will aid in assessment of cartilage in a specific subregion of the knee.
Cartilage ; Cartilage, Articular* ; Femur ; Knee* ; Magic ; Magnetic Resonance Imaging ; Patella ; Volunteers

OBJECTIVES: We examined magical ideation in adolescent and adult group by Magical Ideation Scale (MIS). We also explored how adolescents and adults respond differently to each items of MIS. METHODS: 310 nonclinical adults and 310 Year 10 students participated in this study, and completed MIS and Symptom Checklist 90-revision (SCL-90-R). Total scores of MIS were compared between adults and adolescents. The item characteristics of MIS were evaluated by item response theory (IRT). Differential item functioning (DIF) was detected using the parameters of IRT. RESULTS: Total score of MIS was higher in adolescents than in adults, but there was no statistical significance. Item 5, 10, 13, and 16 showed significant difference on item difficulty parameters and were identified as DIF. Among DIF items, item 5 was more difficult for adolescents than adults. Item 10, 13, and 16 were more difficult for adults than adolescents. The modified MIS score excluding 4 DIF items was significantly higher in adolescents than adults. CONCLUSION: The influence of age on response to DIF items should be considered when comparing MIS scores between adolescents and adults.
Adolescent* ; Adult* ; Checklist ; Humans ; Magic*

PURPOSE: According to current guidelines, perioperative chemotherapy is an integral part of the treatment strategy for advanced gastric cancer. Randomized controlled studies have been conducted in order to determine whether perioperative chemotherapy leads to improved R0 resection rates, fewer recurrences, and prolonged survival. The aim of our project was to critically appraise three major studies to establish whether perioperative chemotherapy for advanced, potentially resectable gastric cancer can be recommended on the basis of their findings. MATERIALS AND METHODS: We analyzed the validity of the three most important studies (MAGIC, ACCORD, and EORTC) using a standardized questionnaire. Each study was evaluated for the study design, patient selection, randomization, changes in protocol, participating clinics, preoperative staging, chemotherapy, homogeneity of subjects, surgical quality, analysis of the results, and recruitment period. RESULTS: All three studies had serious shortcomings with respect to patient selection, homogeneity of subjects, changes in protocol, surgical quality, and analysis of the results. The protocols of the MAGIC and ACCORD-studies were changed during the study period because of insufficient recruitment, such that carcinomas of the lower esophagus and the stomach were examined collectively. In neither the MAGIC study nor the ACCORD study did patients undergo adequate lymphadenectomy, and only about half of the patients in the chemotherapy group could undergo the treatment specified in the protocol. The EORTC study had insufficient statistical power. CONCLUSIONS: We concluded that none of the three studies was sufficiently robust to justify an unrestrained recommendation for perioperative chemotherapy in cases of advanced gastric cancer.
Drug Therapy* ; Esophagus ; Humans ; Lymph Node Excision ; Magic ; Patient Selection ; Random Allocation ; Recurrence ; Stomach ; Stomach Neoplasms* ; Surveys and Questionnaires

The genetic regulation of glucose and insulin levels might be modified by adiposity. With regard to the genetic factors that are altered by adiposity, a large meta-analysis on the interactions between genetic variants and body mass index with regard to fasting glucose and insulin levels was reported by the Meta-Analyses of Glucose- and Insulin-related trait Consortium (MAGIC), based on European ancestry. Because no replication study has been performed in other ethnic groups, we first examined the link between reported single-nucleotide polymorphisms (SNPs) and fasting glucose and insulin levels in a large Korean cohort (Korean Genome and Epidemiology Study cohort [KoGES], n = 5,814). The MAGIC study reported 7 novel SNPs for fasting glucose levels and 6 novel SNPs for fasting insulin levels. In this study, we attempted to replicate the association of 5 SNPs with fasting glucose levels and 5 SNPs with fasting insulin levels. One SNP (rs2293941) in PDX1 was identified as a significant obesity-modifiable factor in Koreans. Our results indicate that the novel loci that were identified by MAGIC are poorly replicated in other ethnic groups, although we do not know why.
Adiposity ; Body Mass Index* ; Cohort Studies ; Epidemiology ; Ethnic Groups ; Fasting* ; Genome ; Glucose* ; Humans ; Insulin* ; Magic ; Polymorphism, Single Nucleotide