6.A review of child sexual abuse cases presenting to a paediatric emergency department.
Magdalene H M LEE ; Sashikumar GANAPATHY ; Soo Mei LOW ; Christine L Q CHUA ; Shu Ling CHONG ; Eric MA ; Peter C Y WONG
Annals of the Academy of Medicine, Singapore 2021;50(7):527-535
		                        		
		                        			INTRODUCTION:
		                        			Child sexual abuse (CSA) adversely affects a child's growth and well-being. This study aimed to describe the profile of children presenting to a tertiary paediatric emergency department(ED) with CSA.
		                        		
		                        			METHODS:
		                        			Children 0-16 years old presenting to KK Women's and Children's Hospital ED from June 2016 to August 2020 with sexual abuse were retrospectively reviewed. We performed a secondary analysis on girls and stratified them by age <13 and ≥13 years old.
		                        		
		                        			RESULTS:
		                        			There were 790 patients who made 833 visits for CSA. Victims were predominantly girls (747, 94.8%) and perpetrators were predominantly men (763, 96.6%). The abuse first occurred before the age of 13 years in 315 victims (39.9%). For 468 (59.2%), more than one incident occurred before presentation. Compared to girls ≥13 years old, girls <13 years old were more frequently abused by a family member (47.7% versus 8.0%, 
		                        		
		                        			CONCLUSION
		                        			The findings highlight common characteristics of CSA cases, and can aid the future identification and protection of vulnerable children. The fact that most children presented after more than one incident suggests the need to more closely monitor and protect potentially at-risk children.
		                        		
		                        		
		                        		
		                        			Adolescent
		                        			;
		                        		
		                        			Child
		                        			;
		                        		
		                        			Child Abuse
		                        			;
		                        		
		                        			Child Abuse, Sexual
		                        			;
		                        		
		                        			Child, Preschool
		                        			;
		                        		
		                        			Emergency Service, Hospital
		                        			;
		                        		
		                        			Female
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Infant
		                        			;
		                        		
		                        			Infant, Newborn
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Parents
		                        			;
		                        		
		                        			Retrospective Studies
		                        			
		                        		
		                        	
8.Prophylactic Dual Catheter Technique to Prevent Side Branch Snowplowing Complications during Angioplasty and Stenting.
Leonard LL YEO ; W M WU ; Y L CHEN ; C H YEH ; H F WONG
Journal of Cerebrovascular and Endovascular Neurosurgery 2017;19(1):12-18
		                        		
		                        			
		                        			OBJECTIVE: Angioplasty and Stenting of intracranial atherosclerotic lesions have a higher complication rate and a large proportion of this is attributable to side branch arterial occlusion from forceful displacement of the atheroma into the ostia or snowplowing effect. This can result in severe disabilities when it result in small infarcts involving eloquent areas in the posterior circulation or the motor tracts. MATERIALS AND METHODS: We present a series of 6 cases utilizing a new dual catheter technique for maintaining the patency of at-risk vessels during angioplasty and stenting. There are several methods previously described to help reduce the incidence of stroke but because they do not have a physical presence in the ostia to protect it, they are unable to guarantee the patency of the vessel. RESULTS: All 6 patients underwent angioplasty and stenting with the technique. The patients were assessed for complications with post-procedure magnetic resonance imaging and no complications were found. CONCLUSION: In this preliminary series, the dual catheter technique appears to safe and effective in preventing occlusion of the adjacent branch arteries. This technique may facilitate the use of the Wingspan stent in the treatment of intracranial atherosclerotic stenotic segments by reducing the risk of peri-procedural stroke.
		                        		
		                        		
		                        		
		                        			Angioplasty*
		                        			;
		                        		
		                        			Arteries
		                        			;
		                        		
		                        			Catheters*
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Incidence
		                        			;
		                        		
		                        			Magnetic Resonance Imaging
		                        			;
		                        		
		                        			Plaque, Atherosclerotic
		                        			;
		                        		
		                        			Stents*
		                        			;
		                        		
		                        			Stroke
		                        			
		                        		
		                        	
9.Pharmacological and Safety Profile of Dexlansoprazole: A New Proton Pump Inhibitor - Implications for Treatment of Gastroesophageal Reflux Disease in the Asia Pacific Region.
Khean Lee GOH ; Myung Gyu CHOI ; Ping I HSU ; Hoon Jai CHUN ; Varocha MAHACHAI ; Udom KACHINTORN ; Somchai LEELAKUSOLVONG ; Nayoung KIM ; Abdul Aziz RANI ; Benjamin C Y WONG ; Justin WU ; Cheng Tang CHIU ; Vikram SHETTY ; Joseph C BOCOBO ; Melchor M CHAN ; Jaw Town LIN
Journal of Neurogastroenterology and Motility 2016;22(3):355-366
		                        		
		                        			
		                        			Although gastroesophageal reflux disease is not as common in Asia as in western countries, the prevalence has increased substantially during the past decade. Gastroesophageal reflux disease is associated with considerable reductions in subjective well-being and work productivity, as well as increased healthcare use. Proton pump inhibitors (PPIs) are currently the most effective treatment for gastroesophageal reflux disease. However, there are limitations associated with these drugs in terms of partial and non-response. Dexlansoprazole is the first PPI with a dual delayed release formulation designed to provide 2 separate releases of medication to extend the duration of effective plasma drug concentration. Dexlansoprazole has been shown to be effective for healing of erosive esophagitis, and to improve subjective well-being by controlling 24-hour symptoms. Dexlansoprazole has also been shown to achieve good plasma concentration regardless of administration with food, providing flexible dosing. Studies in healthy volunteers showed no clinically important effects on exposure to the active metabolite of clopidogrel or clopidogrel-induced platelet inhibition, with no dose adjustment of clopidogrel necessary when coprescribed. This review discusses the role of the new generation PPI, dexlansoprazole, in the treatment of gastroesophageal reflux disease in Asia.
		                        		
		                        		
		                        		
		                        			Asia*
		                        			;
		                        		
		                        			Blood Platelets
		                        			;
		                        		
		                        			Delayed-Action Preparations
		                        			;
		                        		
		                        			Delivery of Health Care
		                        			;
		                        		
		                        			Dexlansoprazole*
		                        			;
		                        		
		                        			Efficiency
		                        			;
		                        		
		                        			Esophagitis
		                        			;
		                        		
		                        			Gastroesophageal Reflux*
		                        			;
		                        		
		                        			Healthy Volunteers
		                        			;
		                        		
		                        			Plasma
		                        			;
		                        		
		                        			Prevalence
		                        			;
		                        		
		                        			Proton Pump Inhibitors
		                        			;
		                        		
		                        			Proton Pumps*
		                        			;
		                        		
		                        			Protons*
		                        			
		                        		
		                        	
10.Association Between Leisure Time Physical Activity, Cardiopulmonary Fitness, Cardiovascular Risk Factors, and Cardiovascular Workload at Work in Firefighters.
Clare C W YU ; Chun T AU ; Frank Y F LEE ; Raymond C H SO ; John P S WONG ; Gary Y K MAK ; Eric P CHIEN ; Alison M MCMANUS
Safety and Health at Work 2015;6(3):192-199
		                        		
		                        			
		                        			BACKGROUND: Overweight, obesity, and cardiovascular disease risk factors are prevalent among firefighters in some developed countries. It is unclear whether physical activity and cardiopulmonary fitness reduce cardiovascular disease risk and the cardiovascular workload at work in firefighters. The present study investigated the relationship between leisure-time physical activity, cardiopulmonary fitness, cardiovascular disease risk factors, and cardiovascular workload at work in firefighters in Hong Kong. METHODS: Male firefighters (n = 387) were randomly selected from serving firefighters in Hong Kong (n = 5,370) for the assessment of cardiovascular disease risk factors (obesity, hypertension, diabetes mellitus, dyslipidemia, smoking, known cardiovascular diseases). One-third (Target Group) were randomly selected for the assessment of off-duty leisure-time physical activity using the short version of the International Physical Activity Questionnaire. Maximal oxygen uptake was assessed, as well as cardiovascular workload using heart rate monitoring for each firefighter for four "normal" 24-hour working shifts and during real-situation simulated scenarios. RESULTS: Overall, 33.9% of the firefighters had at least two cardiovascular disease risk factors. In the Target Group, firefighters who had higher leisure-time physical activity had a lower resting heart rate and a lower average working heart rate, and spent a smaller proportion of time working at a moderateintensity cardiovascular workload. Firefighters who had moderate aerobic fitness and high leisuretime physical activity had a lower peak working heart rate during the mountain rescue scenario compared with firefighters who had low leisure-time physical activities. CONCLUSION: Leisure-time physical activity conferred significant benefits during job tasks of moderate cardiovascular workload in firefighters in Hong Kong.
		                        		
		                        		
		                        		
		                        			Cardiovascular Diseases
		                        			;
		                        		
		                        			Developed Countries
		                        			;
		                        		
		                        			Diabetes Mellitus
		                        			;
		                        		
		                        			Dyslipidemias
		                        			;
		                        		
		                        			Firefighters*
		                        			;
		                        		
		                        			Heart Rate
		                        			;
		                        		
		                        			Hong Kong
		                        			;
		                        		
		                        			Humans
		                        			;
		                        		
		                        			Hypertension
		                        			;
		                        		
		                        			Leisure Activities*
		                        			;
		                        		
		                        			Male
		                        			;
		                        		
		                        			Motor Activity*
		                        			;
		                        		
		                        			Obesity
		                        			;
		                        		
		                        			Overweight
		                        			;
		                        		
		                        			Oxygen
		                        			;
		                        		
		                        			Risk Factors*
		                        			;
		                        		
		                        			Smoke
		                        			;
		                        		
		                        			Smoking
		                        			
		                        		
		                        	
            
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