Lipoblastoma is a rare benign tumor with 80–90% occurring in children less than 3 years of age and 40% occurring in children less than 1 year of age. The most common site of incidence is limb, and then trunk. Neck is the rare site of incidence. The main symptom that the patient complains about is a rapidly growing neck mass without pain. When the size of mass increases, it can cause dyspnea, Horner's syndrome. Lipoblastoma is usually diagnosed as a lipoma in the fine needle aspiration. Since it is not differentiated from lipoma, liposarcoma, and hibernating adenoma in CT and MRI, the definitive diagnosis is histologic diagnosis through surgical resection. The treatment is complete surgical resection. And recurrence rate is 9–25% due to incomplete resection. Authors report this case with a review of literatures since we experienced a case of lipoblastoma diagnosed histopathologically after surgical treatment of neck mass.
Adenoma ; Biopsy, Fine-Needle ; Child ; Diagnosis ; Dyspnea ; Extremities ; Horner Syndrome ; Humans ; Incidence ; Lipoblastoma ; Lipoma ; Liposarcoma ; Magnetic Resonance Imaging ; Neck ; Pediatrics ; Recurrence

Palpable inguinal mass in children should be differentiated from inguinal hernia, hydrocele, lymph node, and tumor. Though using ultrasonography, fatty tumor would be misdiagnosed as incarcerated inguinal hernia containing fatty component. We experienced the huge inguinal lipoblastoma in 5-year-old girl mimicking recurrent incarcerated hernia. Laparoscopic exploration revealed it was not incarcerated hernia but well demarcated bulging mass from abdominal wall. Mass was about 10x4x3 cm and extended from internal inguinal ring to saphenous opening. It was near total excised because of right external iliac vein injury. Pathologically, it was proven as lipoblastoma containing mature adipocyte with lipoblast and fibrous septa. Postoperatively, we noticed a segmental thrombotic occlusion of external iliac vein. After 1 year, she has no symptom related to occluded vessel. The remained lipoblastoma showed no interval change. Even lipoblastoma has a good prognosis with low recurrence rate, we need careful follow-up.
Abdominal Wall ; Adipocytes ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Hernia ; Hernia, Inguinal* ; Humans ; Iliac Vein ; Inguinal Canal ; Lipoblastoma* ; Lipoma ; Lymph Nodes ; Prognosis ; Recurrence ; Ultrasonography

Cell Differentiation ; Child ; Dermatofibrosarcoma ; metabolism ; pathology ; Diagnosis, Differential ; Humans ; Immunohistochemistry ; Infant ; Lipoblastoma ; metabolism ; pathology ; Liver Neoplasms ; metabolism ; pathology ; Mesenchymoma ; metabolism ; pathology ; Neoplasms, Germ Cell and Embryonal ; metabolism ; pathology ; Sarcoma ; metabolism ; pathology ; Skin Neoplasms ; metabolism ; pathology ; Soft Tissue Neoplasms ; metabolism ; pathology

Lipoblastoma is a rare, benign tumor arising from embryonic fat tissues that continue to proliferate in the postnatal period. So, lipoblastoma occurs almost exclusively in infants and children younger than 3 years of age. Published reports showed that 70~90% of cases occur before the age of 3. Histopathologically, lipoblastoma, mimicking liposarcoma, was composed of well-defined lobulated fat tissue with multilobulated lipoblasts, undifferentiated mesenchymal cells, such as stellate or spindle cells and minimal myxoid stromas. The diagnosis of lipoblastoma is important because its management differs from that of lipoma and liposarcoma. To our knowledge, there are only a few reports of lipoblastoma in the Korean dermatologic literature. Herein, we present an interesting and atypical case of lipoblastoma in 68-year-old woman.
Aged ; Child ; Female ; Humans ; Infant ; Lipoblastoma ; Lipoma ; Liposarcoma

Lipoblastomas are rare benign tumors of infancy originating from embryonic fat cells that continue to proliferate in the postnatal period. Lipoblastomas usually affect children younger than 3 years of age. Lipoblastomas may mimic other infantile tumors, including hemangiomas, lymphangiomas, lipomas, and liposarcomas. A correct diagnosis is necessary to ensure appropriate treatment. We witnessed a case of a 5-month-old boy who presented with a very firm, round, well-circumscribed mass on the posterior part of the right lower leg. On magnetic resonance imaging, a hemangioma was suspected. However, histopathological examination revealed a lobulated adipose tissue composed of a mixture of immature multivacuolated lipoblasts and mature adipocytes without nuclear atypia. Based on the clinical and histopathological findings, the diagnosis of benign lipoblastoma was made.
Adipocytes ; Adipose Tissue ; Child ; Dietary Sucrose ; Hemangioma ; Humans ; Hydrazines ; Infant ; Leg ; Lipoblastoma ; Lipoma ; Liposarcoma ; Lymphangioma ; Magnetic Resonance Imaging ; Wit and Humor as Topic

Lipoblastoma is a rare benign tumor that usually originates in children from the embryonic lipid cells of the extremities. This condition shows an early childhood occurrence, a benign nature without metastasis, a cellular composition of mainly mature lipid cells and an ability to differentiate into a simple lipoma. We have experienced a 15 month old girl who had developed a lipoblastoma in the right anterior mediastinum. Surgical resection was carried out without complications. Her postoperative course was uneventful. She has been well 6 months after the operation.
Child ; Extremities ; Humans ; Lipoblastoma ; Lipoma ; Mediastinal Neoplasms ; Mediastinum ; Neoplasm Metastasis

Lipoblastoma is a rare benign mesenchymal tumor that occurs primarily in infancy and childhood. There are two types of lipoblastoma: focal or diffuse (lipoblastomatosis). This is typically located in the extremities, and less frequently in the trunk, head and neck, and the retroperitoneum. Lipoblastoma is a tumor with a good prognosis with no reported metastasis, despite of its potential for local invasion, local recurrence and rapid growth. Complete surgical resection is essential for treatment, and long term follow up is needed.
Extremities ; Follow-Up Studies ; Head ; Humans ; Lipoblastoma* ; Male* ; Neck ; Neoplasm Metastasis ; Prognosis ; Recurrence ; Thoracic Wall* ; Thorax*

Mediastinal lipoblastoma is a rare benign tumor originating from embryonic lipid cells and it almost always occurs during infanthood or early childhood. It is a tumor with a good prognosis despite its potential for local invasion and rapid growth. We report here on a three years old girl who was treated for a benign lipoblastoma in the anterior mediastinum. CT scanning showed a fat containing mass without internal calcification or fluid component, and the mass showed a compressive effect on the adjacent structures. The mass was located between the pericardium and right mediastinal pleura and it was removed completely without complication. Pathologic examination revealed a benign lipoblastoma. The patient showed no evidence of recurrence at the time of the report.
Female ; Humans ; Lipoblastoma* ; Mediastinum ; Pericardium ; Pleura ; Prognosis ; Recurrence ; Tomography, X-Ray Computed

Lipoblastoma is a rare benign soft tissue tumor occurring in infancy and early childhood. It is characterized by fat lobules with varying degrees of maturity, multivaculoated lipoblasts, fibrocapillary networks and myxoid stroma. Lipoblastoma has a good prognosis with no metastases despite its potential for local invasion. From Jan, 1990 through April, 2007, 12 children underwent the operation for lipoblastoma, 7 boys and 5 girls, diagnosed at median 22 months (5~43 months). Median follow up was 6 year 7 months. Primary sites included back (n=5), intraabdominal (n=2) and one in each of buttock, chest wall, neck, nose and scalp. Tumors presented with a growing mass in 9 patients, abdominal distension in 2, and an incidental finding on chest radiography in one. Complete excisions were done in all patients. There was one recurrence in a patient with a scalp mass. After reoperation, he has been doing well without evidence of recurrence. Lipoblastoma has a favorable prognosis, but recurrence can occur even with complete excision. Regular follow up is necessary to detect recurrences.
Buttocks ; Child* ; Female ; Follow-Up Studies ; Humans ; Incidental Findings ; Lipoblastoma* ; Neck ; Neoplasm Metastasis ; Nose ; Prognosis ; Radiography ; Recurrence ; Reoperation ; Scalp ; Thoracic Wall ; Thorax

Lipoblastoma is a relatively rare benign tumor that occurs in infancy and early childhood, and it arises from embryonic white fat. It is classified into two forms based on pathologic features: benign lipoblastoma is a superficial, well-defined mass and diffuse lipoblastomatosis is a deep, infiltrative lesion. They are both histologically benign, but local recurrences can happen without any tendency of metastasis. The prevalent sites are chiefly the upper and the lower extremities and less commonly the head, neck, trunk, mesentery, mediastinum, and retroperitoneum. The treatment of choice is surgical excisions, and the prognosis is good, but recurrence is possible in the case of incomplete excision, so wide local excision is preferred. We experienced a locally recurrent lipoblastoma in an 8 month old female child in the chest wall that reoccurred three months after the primary excision. Because 9th and 10th rib invasion was suspected on magnetic resonance imaging study, mass excision along with partial 9th and 10th ribs resection was performed. The histologic diagnosis confirmed lipoblastoma.
Adipose Tissue, White ; Child* ; Diagnosis ; Female ; Head ; Humans ; Infant ; Lipoblastoma* ; Lower Extremity ; Magnetic Resonance Imaging ; Mediastinum ; Mesentery ; Neck ; Neoplasm Metastasis ; Prognosis ; Recurrence ; Ribs ; Thoracic Wall* ; Thorax*