Patent foramen ovale(PFO), a congenital structural lesion that allows shunting of blood from the right to the left atrium, has been increasingly recognized as the main cause of cryptogenic stroke. The mechanism of PFO-related cryptogenic stroke is attributed to paradoxical embolism into the arterial system via PFO. A large number of domestic and foreign studies have confirmed the efficacy and safety of percutaneous PFO closure in the secondary prevention of a series of diseases including cryptogenic stroke and migraine. Percutaneous PFO closure is a mature and safe operation overall, but its corresponding complications are still unavoidable. We mainly introduce PFO closure and its related complications in this paper, aiming to enhance clinicians' understanding of this operation and its complications, so as to reduce some unnecessary troubles in clinical work.