Objective:To explore the effects of perioperative emergency scene two-step simulation drill for cancer patients in medical and nursing staff training.Methods:From August 2018, this study selected 19 nurses and 10 doctors in Oncology Surgery of the First People's Hospital of Fuyang Hangzhou as subjects by convenience sampling. Subjects all received the emergency scene two-step simulation drill. We compared the theoretical knowledge and operational skills before and after training for medical staff.Results:After training, the theoretical knowledge and operational skills of medical and nursing staff were higher than those before training with statistical differences ( P<0.05) . Conclusions:Perioperative emergency scene two-step simulation drill for medical staff of Oncology Surgery can creative a good environment for medical staff and improve the theoretical knowledge and operational skills of medical staff so as to ensure the security of perioperative cancer patients.