Objective:To evaluate the effect of nutrition care process and model (NCPM) intervention on the quality of life and nutritional status in patients with non-small cell lung cancer.Methods:A case-control study was conducted among 80 patients with non-small cell lung cancer treated at The 903 Hospital of the PLA Joint Logistics Support Force between January 2023 and February 2024. Based on different intervention methods, these patients were divided into a control group and a study group, with 40 patients in each group. The control group received traditional intervention, while the study group underwent intervention using the NCPM. Negative emotions, anthropometric indices (upper arm muscle circumference, triceps skin thickness, body mass index), blood indices (total serum protein, hemoglobin, serum albumin), quality of life, and immune function indices were compared between the two groups before and after the intervention.Results:After the intervention, the scores on the Self-Rating Depression Scale and Self-Rating Anxiety Scale in the study group were (17.37 ± 1.78) points and (16.48 ± 1.27) points, respectively, which were significantly lower than those in the control group [(26.21 ± 2.01) points, (25.11 ± 1.36) points, t = 20.82, 29.33, both P < 0.001]. The body mass index, triceps skin thickness, and upper arm muscle circumference in the study group were (19.62 ± 0.18) kg/m 2, (9.85 ± 0.23) mm, and (25.81 ± 0.40) cm, respectively, which were significantly higher than those in the control group [(19.32 ± 0.25) kg/m 2, (9.71 ± 0.16) mm, (25.16 ± 0.33) cm, t = 6.16, 3.16, 20.12, all P < 0.05]. The hemoglobin, total serum protein, and serum albumin levels in the study group were significantly higher compared with those in the control group ( t = 3.93, 4.41, 6.15, all P < 0.05). The scores for social function, material life, physical function, and psychological function in the study group were significantly higher than those in the control group ( t = 8.64, 3.44, 3.62, 7.71, all P < 0.05). The study group had significantly higher CD 4+ and CD 4+/CD 8+ values, with (44.12 ± 5.93)% and (1.94 ± 0.43), respectively, compared with the control group [(40.08 ± 5.21)% and (1.52 ± 0.28), t = 3.24, 5.18, both P < 0.05]. The CD 8+ value in the study group was (23.18 ± 2.11)%, which was significantly lower than that in the control group [(27.01 ± 2.73)%, t = 7.02, P < 0.05]. Conclusion:The intervention utilizing the NCPM model effectively enhances the diet structure in patients with non-small cell lung cancer, standardizes the nutritional management process for these patients, and ultimately improves their overall quality of life.