Health-related quality of life is one of the important concepts for developing research and practice in medicine and health.Considering the phenomenon of response shift in relevant studies can help to accurately grasp the Quality of Life change and provide more specialized analytical and causal interpretive pathways,and improve the scientific understanding of the quality of life of different groups.Starting from the connotation analysis of health-related quality of life and response shift,it discusses the existence of response shift phenomenon and its impact on the design,implementation and specific evaluation of quality of life evaluation scale on the basis of a systematic review of its mainstream research paradigm.Then,the improvement suggestions for health-related quality of life evaluation in China are put forward from the aspects of improving the design of the quality of life scale,optimizing the scale evalua-tion process,expanding the scale evaluation group,and introducing international mainstream reaction transfer detection methods.