Objective: To observe the effects of multi sensory stimulation (MSS) intervention on the psychological state, neurobiology, and neuroelectrophysiological indicators of college students with Internet addiction disorder (IAD), so as to provide high quality evidence for the optimization of IAD intervention plans. Methods: At the beginning of the spring semester of 2022-2023 academic year, 114 first year and sophomore IAD college students from Chongqing Second Normal University were selected by group random sampling method, and were randomly assigned into control group, physical exercise group, and observation group (28 in each group). The control group received routine psychological intervention, while the physical exercise group received routine physical exercise on the basis of the control group. The observation group received a MSS intervention on the basis of the control group. The MSS intervention included 8 means of color, incense, music, lozenges, press needle, massage, Tai Chi and static work. The intervention periocl was from April 1 to June 30, 2023, and all three groups were intervened for 12 weeks. The revised Chinese Internet Addiction Scale (CIAS-R), Self Control Scale (SCS), Symptom Checklist-90 (SCL-90) were observed before and after intervention, dopamine (DA) and β Endorphin (β EP) concentration were collected, and the amplitude and latency levels of N200 were analyzed by Event Related Potential (ERP). Results: The CIAS-R score of the observation group (36.08±4.98) was lower than physical exercise group (49.55±5.19) and control group (54.82±4.10), and the SCS score of the observation group (76.08± 1.98 ) was higher than physical exercise group (66.16±1.92) and control group (52.59±1.53) ( F=12.08, 13.18, P <0.05). In comparison of various dimensions of SCL-90, the observation group showed lower scores in the four dimensions of somatization, depression, anxiety, and psychoticism compared to the other two groups ( F=9.11, 8.92, 8.17, 8.48, P <0.05). In the dimensions of obsessive-compulsive symptoms, interpersonal sensitivity, and others in observation group were lower than the control group ( F= 4.20 , 5.16, 5.60, P <0.05). However, there was no difference in the two dimensions of terror and paranoia among the three groups ( F=0.24, 0.19, P > 0.05). The levels in plasma DA, βEP and the amplitude and latency of N200 among observation group were better than other two groups, and the differences were statistically significant ( F=9.92, 8.93, 6.24, 8.05, P <0.05). Conclusion MSS intervention can alleviate the related symptoms of IAD college students, improve neurobiological and neurophysiological indicators.

Objective: To observe the effect of dynamic and static combination of Wuqinxi on the psychological state and prefrontal oxygenated hemoglobin of female college students with subliminal depression (SD), so as to provide a high quality reference for optimizing their interventional measures. Methods: A total of 72 female college students with SD in their third year of two semesters in the 2021-2022 academic year of Chongqing Second Normal University were randomly divided into a control group, an observation group 1, and an observation group 2. The control group received routine psychological intervention once a week, 20 minutes/time, while the observation group 1 received Wuqinxi exercise twice a day for about 30 minutes on the basis of the control group. The observation group 2 received a combination of dynamic and static Wuqinxi exercise on the basis of the control group, Wuqinxi dynamic exercise combined with Wuqinxi exercise guided imagination training about 20 minutes/time. All three groups received 12 weeks of intervention. Observe the Chinese version of the Hamilton Depression Scale (HAMD-24), Subthreshold Depression Scale (STDS), and Symptom Checklist-90 (SCL-90) before and after intervention, and collect serum γ aminobutyric acid (GABA) and plasma adrenocor ticotropic hormone (ACTH), and the concentration of oxyhemoglobin (Oxy Hb) in the prefrontal lobe were detected by functional near infrared spectroscopy (fNIRS). Results: The results showed that the HAMD-24 and STDS scores of the two groups (11.33±1.29, 53.08±2.31) were lower than those of the control group and observation group 1 (18.27± 2.02 , 73.60±4.05; 15.19±1.92, 64.58±2.69), with statistically significant differences ( F=8.64, 11.85, P <0.05). Observing that the six dimensions of somatization, interpersonal, depression, anxiety, hostility psychoticism in the SCL-90 scale were lower in the two groups than in the other two groups ( F=3.68, 9.83, 10.37, 5.85, 3.05, 7.46, P <0.05). The plasma ACTH levels in the observation group were lower than those in the other two groups, while the peak concentration of Oxy Hb was higher than those in the other two groups ( F =3.27, 6.08, P <0.05). The serum GABA levels were higher than those in the control group, and there was no difference compared to the observation group 1 ( P >0.05). Conclusion The combination of dynamic and static Wuqinxi training can improve the psychological state of female college students with subthreshold depression, alleviate the depressive symptoms,possibly through increase of prefrontal oxygenated hemoglobin.