bjective? To explore the coping trajectory based on grounded theory of primary family caregivers among stroke patients to confirm the coping process of primary family caregivers of stroke patients. Methods? From June 2017 to June 2018, a theoretical sampling method was used to select some caregivers of stroke patients with initial or recurrent episodes in the acute phase. Depth interviews were carried based on grounded theory method among 10 primary family caregivers of stroke patients. Interview data were coded to form category and core category. Results? Coping process of primary family caregivers of stroke patients was divided into four phases, including chaotic phase, confrontation phase, learning and coexistence phase as well as transcending phase. In general, four phases went by turn. However, the order may be disorganized at times when caregivers were with different situations. Conclusions? Medical staff should provide corresponding health education by combining coping characteristics of different phase, increase support of communities, carry out multiple measures and improve coping of caregivers.