One-hundred and five letters were send to85cases who discontinued to receive our medical care. Half of them again visited the clinic responding to the letters. To the remaining half of the cases neither repeated letters nor the visits from public health nurses were fruitful with3exeptions. Most of them said that they were quite free from their symptoms.

Fourteen cases of active urinary tract tuberculosis out of5510patients were reported. Four had a previous genitourinary tuberculous infection. There were ten patients presented with bladder symptoms. Most of the cases were treated over months as non-specific urinary tract infection before they visited our clinic. Delay in diagnosis results in the loss of the kidney and bladder.

The management of the urethral injury which does not pass a catheter is difficult. As the results of primary reconstruction are unsatisfactory, I prefer suprapubic trocar cystostomy for the first stage. For two of three cases treated with this principle no further surgical procedure was necessary.

The results obtained from epidemiological studies of hepatitis B antigen-antibody system in a rural village were reported. The studies were carried for 5 years on 2719 persons. Among them 1.1% were chronic surface antigen carriers, 0.2% were transiently antigen-positive in turn and 20.0% were antibody-positive.
Some of the antigen carriers showed familial clustering. All surface antigen carriers with e-antibody, however, did not show familial clustering except one case. Subtype of adr is prevalent in this area. 13of15persons whose subtypes were identified, showed adr subtype. The remaining2were adw, and they were sporadic cases with no familial clustering. In a community a large family pedigree of carriers was discovered. Both antigen and antibody were prevalent among persons living in the community.
Among pick-upped 144 persons who showed abnormal liver functions, 12 (8.3%) were found to be surface antigenpositive

Two-hundred and eighty-two consecutive transurethral resections were reviewed. No postoperative death occurred. Transfusion was unnessesary. The largest prostate needed 69minutes and the resected tissues weighed 92gm. Uncomplicated cases were discharged after a week's hospital stay. Prostatic hypertrophy and related conditions are common among farmers. Transurethral resection is safe and beneficial to them.

It is the purpose of this manuscript to demonstrate the suppressive effect of methyl phosphates on germinal tissue with a score method.
The phosphates were orally given to monkeys and rabbits for12to27weeks with no evident weight loss. The suppressive effect was shown as the decreased germ cell score count.

The purpose of the present report is to describe experiences during the second year of the outpatient clinic. New 1229 patients visited a year.
Cystitis, benign prostatic hypertrophy and upper urinary tract stone were three major diseases. Stones were, however, encountered less frequently as compared with the urban areas. Acute cystitis often developed in females after they had planted rice in paddy fields. They used to continue the work even in rain, and no places suitable for urination are available in the field.
General practitioners do not clarify the differential diagnosis of urinary tract infection and of hematuria. Cystitis is the diagnosis; antibiotics is the treatment. Neoplasm, therefore, becomes unresectable, tuberculosis causes contracted bladder, and stone deteriolates the kidney function.

The pollution of our environment by a variety of mutagenic agents has been at issue in the last few years. The herbicide 2, 4, 5-trichlorophenoxyacetic acid (2, 4, 5-T) has turned out to be a potent mutagenic agent. Therefore, we evaluated the cytogenetic effect of this compound on the human leukocyte in vitro. Chromatid aberrations were observed and it was found that their incidence increases in proportion to a rise in dose.
It has been claimed that the teratogenic effects of 2, 4, 5-T may be attributed to the presence of 2, 3, 7, 8-tetrachlorobenzo-p-dioxin (dioxin) as an impurity. The compound used in our study contained 0.09μg/g of dioxin. Although the level of contamination is low, the possible roleof dioxin cannot be ruled out. Nevertheless, the fact remains that the mutagenic effects of the compound now available are undeniable.

In a year, from the beginning of my clinic on July 1972 until June 1973, 1, 110 patients have visited; 628 were male and 482 were female.Males showed the tendency to retain hospital visit in spring and autumn when they are busy with farming.Out of 1, 110 patients 71 were refered from doctors outside of the hospital, 346 were from other clinics in the hospital.
Diseases were classified following the International Classification of Disease.Simple cystitis, benign prostatic hypertrophy and upper urinary tract calculi were most frequent.
Their, and also doctors who concerned, misunderstanding and ignorance of recent progress in urological management stimulated me to survey my experience and explain modern trends in the field.Urinary tract tuberculosis were sometimes considered as nonspecific chronic cystitis;ureteral stones were not recognized on x-ray film;postrenal uremic state were confused with renal parenchymal failure. The value of pyelolithotomy in situ and transurethral resection were also stressed.

Preceding reports suggested many asymptomatic hepatitis B virus infection.To ascertain the conclusion sera from patients were studied for half a year.
Three acute hepatitis and 19 asymptomatic infection had occurred among hospitalized patients without apparent chance of exposion.Asymptomatic infection means antigenemia without subjective complaints and biochemical changes.One of them became an antigen carrier and others were transient positives.
The study revealed naturally occurred 9 apparent hepatitis and 26 infections without apparent liver involvement. Most of them were quite symptomless, however, some of them complained malaise, fever, diarrhea, exanthema, itching and/or arthralgia.They showed normal serum GOT value expect one personel and recovered completely.Only one case carried the antigen persistently.
These results support the view.There are frequent chances of the virus infection in this rural area. Most of them recover with no trouble.The rate of aproximately 20%who keep the antibody in the population can be now understood.The ratio of asymptomatic infection to apparent hepatitis may over 6 mals.Some of them become carrier of the antigen.Familial defect in allowance may result the clustering of the antigen carrier in a family.