BACKGROUND: Hand eczema is one of the most common skin disorders and negatively affects quality of life. However, a large-scale multicenter study investigating the clinical features of patients with hand eczema has not yet been conducted in Korea. OBJECTIVE: To identify the prevalence of various hand diseases, which is defined as all cutaneous disease occurring in hands, and to investigate the clinical features of patients with hand eczema and the awareness about hand eczema in the general population and to compare the prevalence of hand eczema between health care providers and non-health care providers. METHODS: To estimate the prevalence of hand diseases, we analyzed the medical records of patients from 24 medical centers. Patients were assessed by online and offline questionnaires. A 1,000 from general population and 913 hand eczema patients answered the questionnaire, for a total of 1,913 subjects. RESULTS: The most common hand disease was irritant contact dermatitis. In an online survey, the lifetime prevalence of hand eczema was 31.2%. Hand eczema was more likely to occur in females (66.0%) and younger (20~39 years, 53.9%). Health care providers and housewives were the occupations most frequently associated with hand eczema. Winter (33.6%) was the most common season which people experienced aggravation. The 63.0% and 67.0% answered that hand eczema hinders their personal relationship and negatively affects daily living activities, respectively. CONCLUSION: Hand eczema is a very common disease and hinders the quality of life. The appropriate identification of hand eczema is necessary to implement effective and efficient treatment.
Activities of Daily Living ; Dermatitis, Contact ; Eczema* ; Female ; Hand* ; Health Personnel ; Humans ; Korea* ; Medical Records ; Occupations ; Prevalence ; Quality of Life ; Seasons ; Skin ; Surveys and Questionnaires

BACKGROUND: Hair growth is spontaneously activated from quiescent bulge stem cells or is activated from precocious anagen. Upon spontaneous activation of hair growth or activation induced by nuclear factor of activated T cells c1 (NFATc1) inhibitors, NFATc1 expression is lost and cyclin dependent kinase (CDK4) repression is relieved. OBJECTIVE: The purpose of this study was to investigate the mechanisms of cyclosporine as a hair cycle regulator in the treatment of Alopecia areata (AA). METHODS: In this study, we planned to investigate the hair growing properties of cyclosporine in vitro conditions. Briefly, the effects of different concentrations of cyclosporine (200, 500, 1,000, 2,000 mmol) on the growth of cultured hair follicles were examined through the expression of NFATc1 and CDK4. RESULTS: NFATc1 was downregulated and CDK4 expression was upregulated especially in the bulge areas, outer root sheath and hair bulb matrix cells as the concentration of cyclosporine increased. CONCLUSION: Cyclosporine induces CDK4 expression by NFATc1 suppression, which acts to relieve repressed CDK4, resulting in hair growth. In conclusion, cyclosporine is one of the candidates as a therapeutic agent for the treatment of hair loss.
Alopecia Areata ; Cyclins ; Cyclosporine* ; Hair Follicle ; Hair* ; Phosphotransferases ; Repression, Psychology ; Stem Cells ; T-Lymphocytes

BACKGROUND: The TRUE test is a commercially available ready-to-apply patch test widely used in many countries, but no large-scale study is available on the TRUE test in Korea. OBJECTIVE: The purpose of this study was to analyze the type, frequency, and changes in the common contact allergens in Korea using the TRUE test. METHODS: From January 2009 to March 2010, TRUE tests were performed on patients with contact dermatitis at the Departments of Dermatology of 15 hospitals. The epidemiological findings of patients, and the results of the patch tests were analyzed. RESULTS: In total, 795 patch tested cases (246 males, 549 females) were compiled and analyzed. The oldest age distribution was the third decade in both males and females, and housewives and office-workers were the most common jobs, comprising 29.7% and 19.8% of the occupations, respectively. Overall, 65.1% of patients had at least one positive reaction, and the most common allergens were nickel sulfate (34.1%), thimerosal (12.6%), cobalt chloride (11.1%), and p-phenylenediamine (8.4%), in order of frequency. A univariate analysis of multiple variables including age, gender, occupation, and affected sites was conducted and a comparison with a previous multicenter study was also analyzed. CONCLUSION: These results provide the basis for use of the TRUE test in patients with contact dermatitis in Korea.
Age Distribution ; Allergens ; Cobalt ; Dermatitis, Contact ; Dermatology ; Female ; Humans ; Korea ; Male ; Nickel ; Occupations ; Patch Tests ; Phenylenediamines ; Thimerosal

OBJECT: The purpose of this study was to determine the prevalence of fungal infection and ulcer on the feet of diabetic patients and the existence of correlation between ulcer and fungal infection. METHODS: A total of 21, 693 outpatients diagnosed as diabetes mellitus at the department of endocrinology of 32 hospitals were examined. The diabetic patients with foot problems were consulted to the department of dermatology. Physical examination and KOH preparation were performed. RESULTS: 13, 271 patients had certain kinds of foot problem, accounting for 61.2% of 21, 693 diabetics examined. Of these, fungal foot disease were found in 10, 403 that constituted 78.4% (48.0% of the entire diabetic population). Tinea pedis was the diagnosis in 6, 496 (29.9%), onychomycosis in 7, 783 (35.9%), and coexistence was in 3, 883 (17.9%). Foot deformity was in 1, 346 (6.2% of diabetics; 10.1% of foot disease), non-palpable pulse in 1, 051 (4.8% ; 7.9%), and foot ulcer was in 425 (2.0% ; 3.2%), following in a descending order of frequency. Odds ratios for diabetic foot ulcer were 2.5 in patients with the foot deformity, 1.6 with fungal foot disease and 2.2 with non-palpable pulse. Conversely, Odds ratios for fungal foot disease were 2.5 with foot deformity, and 1.6 with foot ulcer. A total of 5, 486 patients paid a visit to the department of dermatology. Of these, 4, 519 patients were diagnosed with fungal infection through physical examination and KOH smear by dermatologists. The population comprised of 2, 272 males and 2, 247 females, showing similar prevalence between sexes. However, age did have positive correlation regarding prevalence of fungal foot disease. The number of diabetic patients with toenail problems was 3, 847 patients (70%) and onychomycosis was proven mycologically in 3, 276. Onychomycosis of distal subungal type was the most common clinical finding, most frequently involving the great toenails. Abnormal skin findings of the foot were seen in 3, 885(70.8%) and tinea pedis was found in 3, 209 (58.5%), most commonly involving the soles. CONCLUSION: This study showed that fungal infection might be regarded as a risk factor of foot ulcer. Treatment of fungal infection in diabetic patients might prevent diabetic foot disease such as ulcer and reduce the disability, morbidity and mortality in diabetic patients.
Dermatology ; Diabetes Mellitus ; Diabetic Foot ; Diagnosis ; Endocrinology ; Female ; Foot Deformities ; Foot Diseases ; Foot Ulcer ; Foot* ; Humans ; Male ; Mortality ; Nails ; Odds Ratio ; Onychomycosis ; Outpatients ; Physical Examination ; Prevalence* ; Risk Factors ; Skin ; Tinea Pedis ; Ulcer*

Bednar tumor is an uncommon pigmented subtype of dermatofibrosarcoma protuberans(DFSP). The histopathological finding is characterized by a typical storiform pattern composed of spindle-shaped cells resembling DFSP except for the presence of melanin-containing cells scattered within the lesion. The origin of the spindle-shaped cells and melanin-containing cells within the tumor remains unknown. We report a case of Bednar tumor in a 26-year-old woman on the right shoulder which was presented as asymptomatic, firm, black-colored, 1x1.5 cm nodule over 2 years. Histologically, the proliferated spindle-shaped cells showed a cartwheel pattern and stained positively with CD34, similar to those of a common DFSP. The tumor was widely excised and there is no evidence of recurrence from follow-up of 6 months.
Adult ; Dermatofibrosarcoma ; Female ; Follow-Up Studies ; Humans ; Recurrence ; Shoulder

Allergic contact dermatitis to topical corticosteroids seems to occur more frequently than previously supposed. But it is not easily recognized because the allergic condition for which the steroid is mostly prescribed masks the sensitization. Moreover, corticosteroids evoke some anti-inflammatory effect, even in case of steroid hypersensitivity. A 40-year-old man visited our department for the evaluation of aggravated skin lesion of trunk. Previously he was treated with Dermovate(R) and Eumovate(R) ointment for chronic dermatitis. He was patch tested to the Korean standard series, with Dermovate(R) and Eumovate(R) ointment as is. Patch test showed positive reactions to both ointments.
Adrenal Cortex Hormones ; Adult ; Dermatitis ; Dermatitis, Allergic Contact* ; Humans ; Hypersensitivity ; Masks ; Ointments ; Patch Tests ; Skin

BACKGROUND: Occupational dermatoses are the most prevalent of all occupational diseases. Over the past few decades, the incidence of occupational dermatoses in Korea is increasing with rapid growth in industry. However, there have been only a few reports about occupational dermatoses in Korean dermatologic literature. OBJECTIVE: The purpose of this article is to study the prevalence of occupational dermatoses in a semiconductor industry and to compare these with previous reports. METHODS: A dermatologist attended regularly at the clinic in a semiconductor industry once a week from June 1995 to May 2000. 4, 985 workers diagnosed with skin disease were analyzed. RESULTS: The results can be summarized as follows: Annual incidences are 6.5%(1995.6-1996.5), 5.3%(1996.6-1997.5), 5.2%(1997.6-1998.5), 5.7%(1998.6-1999.5), 5.8%(1999.6-2000.5) and average incidence is 5.7%. In the distribution of dermatoses as disease groups, eczema(28.8%), fungal infection(19.2%), disease of skin appendage(17.6%), erythema, urticaria and drug eruption(9.4%), viral infection(4.9%), constituted 79.9% of the total. Ten most common dermatoses include contact dermatitis(13.1%), acne(12.5%), tinea pedis(11.2%), urticaria(7.5%), hand eczema(6.6%), seborrheic dermatitis(6.2%), onychomycosis(3.0%), alopecia(2.9%), tinea cruris(1.7%) and lichen simplex chronicus(1.6%). Diseases which shows high seasonal distribution in summer are contact dermatitis, tinea pedis, urticaria, tinea cruris. Contact dermatitis(1.7%), acne(1.6%), chemical burn(1.3%) and hand eczema(1.1%) were the most important occupational dermatoses in this survey. The occupational contact dermatitis and acne mainly came from the mask, hood and dust preventing clothes which the workers must wear for 8 hours a day at their work place. Hydrofluoric acid(1.0%) was the main cause of chemical burn. Hand eczema was primarily due to kitchen work, cleaning work and gloves. The other dermatoses related to occupation were trauma, seborrheic dermatitis, atopic dermatitis, xerosis cutis, urticaria, etc. CONCLUSIONS: Comparing these results about occupational dermatoses with previous report (1992.6-1995.5) in a semiconductor industry before, there was relatively low incidence of hydrofluoric acid burn and high incidence of contact dermatitis, acne and hand eczema.
Acne Vulgaris ; Burns ; Burns, Chemical ; Dermatitis, Atopic ; Dermatitis, Contact ; Dermatitis, Seborrheic ; Dust ; Eczema ; Erythema ; Hand ; Hydrofluoric Acid ; Incidence ; Korea ; Lichens ; Masks ; Occupational Diseases ; Occupations ; Prevalence ; Seasons ; Semiconductors* ; Skin ; Skin Diseases* ; Tinea ; Tinea Pedis ; Urticaria ; Workplace

Kaposi's sarcoma is a neoplasm of multifocal origin which manifests primarily as vascular nodules in the skin and other organs. Kaposi's sarcoma in iatrogenically immunocompromised patients is the result of immunosuppressive therapy in organ-transplant recipients, autoimmune disease patients and cytotoxic chemotherapy in cancer patients. We report a case of Kaposi's sarcoma in a 50-year-old man who developed well-defined purple-colored papules and plaques on both hands and feet after prednisolone treatment for underlying membranous glomerulonephritis. The histologic finding showed abnormally proliferated and dilated vessels, vascular slits, spindle-shaped cells and extravasated erythrocytes in the dermis. He was treated with cryotherapy, and the dosage of prednisolone was reduced. Improvement was seen in 6 weeks
Autoimmune Diseases ; Cryotherapy ; Dermis ; Drug Therapy ; Erythrocytes ; Foot ; Glomerulonephritis, Membranous* ; Hand ; Humans ; Immunocompromised Host ; Middle Aged ; Prednisolone ; Sarcoma, Kaposi* ; Skin

Sweet's syndrome, also referred to as acute febrile neutrophilic dermatosis(AFND), is an unusual entity characterized by painful erythematous plaques. Histologically a dense perivascular infiltrate composed predominantly of neutrophils without discernable vascular wall change. Sweet's syndrome can be associated with several disorders, such as inflammatory bowel diseases, various malignant tumors, and autoimmune diseases including rheumatoid arthritis, but the association of Sweet's syndrome with rheumatoid arthritis seems to be uncommon and no case has ever been reported in Korea. Herein we describe a patient who had Sweet's syndrome associated with rheumatoid arthritis.
Arthritis, Rheumatoid* ; Autoimmune Diseases ; Humans ; Inflammatory Bowel Diseases ; Korea ; Neutrophils ; Sweet Syndrome*

Pigmented contact dermatitis is characterized by a dark brown pigmentation that results from repeated exposure to small amounts of contact allergen. Histopathologic findings are liquefactive degeneration of the basal layer cells and melanophages in the upper dermis. We report a case of a 73-year-old man with dark brownish mottled hyperpigmented patches on the both cheeks and forehead. Patch tests were positive to isoeugenol, benzyl salicylate and after shave lotion. After shave lotion that the patient used maybe contain these fragrances. Improvement was seen 3 months after ceasing the use of after shave lotion.
Aged ; Cheek ; Dermatitis, Contact* ; Dermis ; Forehead ; Humans ; Patch Tests ; Pigmentation