Introduction: Alcohol, when used frequently, accelerates the ageing process, causes brain damage, and results in a 
reduced volume of grey and white matter, leading to frontal lobe abnormalities. The neurotoxicity resulting from alcohol overuse affects the higher functions of the brain. This study aimed to evaluate the effect of alcohol dependence 
on the executive functioning of the brain. Methods: This study was carried out as a case-control study among 60 
patients with alcohol dependence and 60 controls. Assessment of executive function was carried out using the Comprehensive trail-making test (CTMT) and the Wisconsin card sorting test (WCST). Comparison between the alcohol 
dependence group and normal healthy controls were calculated using the Mann-Whitney U test as data followed a 
non-parametric distribution. Results: The mean age of the participants among the cases and controls was 38.3±5.5 
years and 37.8±5.4 years, respectively. The results showed a significant difference in both WCST and CTMT between 
cases and controls (p<0.05). Conclusion: This study concludes that there was an impaired performance in executive 
functions in alcohol- dependence patients in early abstinence compared to normal controls showing frontal lobe 
impairment in alcohol-dependence patients.