Maxillary sinus cancers, constituting a minority of head and neck malignancies, exhibit a diverse range of histological subtypes, each necessitating a nuanced approach to diagnosis and treatment. Within this spectrum, mucinous adenocarcinoma stands as an exceedingly rare variant, and this case report aims to provide a thorough examination of its clinical, radiological, and histopathological dimensions within the context of maxillary sinus malignancies. Surgical resection is considered as treatment of choice for this kind of tumor. A 68-year-old male underwent total maxillectomy using Weber-Ferguson incision for maxillary sinus tumor in our department. The pathological report of tumor was revealed as mucinous type adenocarcinoma. The specimen was observed thoroughly, and based on immunohistochemical findings, diagnosed as mucinous type adenocarcinoma. So, we present a rare case of mucinous type adenocarcinoma arising from the maxillary sinus.

Maxillary sinus cancers, constituting a minority of head and neck malignancies, exhibit a diverse range of histological subtypes, each necessitating a nuanced approach to diagnosis and treatment. Within this spectrum, mucinous adenocarcinoma stands as an exceedingly rare variant, and this case report aims to provide a thorough examination of its clinical, radiological, and histopathological dimensions within the context of maxillary sinus malignancies. Surgical resection is considered as treatment of choice for this kind of tumor. A 68-year-old male underwent total maxillectomy using Weber-Ferguson incision for maxillary sinus tumor in our department. The pathological report of tumor was revealed as mucinous type adenocarcinoma. The specimen was observed thoroughly, and based on immunohistochemical findings, diagnosed as mucinous type adenocarcinoma. So, we present a rare case of mucinous type adenocarcinoma arising from the maxillary sinus.

Maxillary sinus cancers, constituting a minority of head and neck malignancies, exhibit a diverse range of histological subtypes, each necessitating a nuanced approach to diagnosis and treatment. Within this spectrum, mucinous adenocarcinoma stands as an exceedingly rare variant, and this case report aims to provide a thorough examination of its clinical, radiological, and histopathological dimensions within the context of maxillary sinus malignancies. Surgical resection is considered as treatment of choice for this kind of tumor. A 68-year-old male underwent total maxillectomy using Weber-Ferguson incision for maxillary sinus tumor in our department. The pathological report of tumor was revealed as mucinous type adenocarcinoma. The specimen was observed thoroughly, and based on immunohistochemical findings, diagnosed as mucinous type adenocarcinoma. So, we present a rare case of mucinous type adenocarcinoma arising from the maxillary sinus.

Maxillary sinus cancers, constituting a minority of head and neck malignancies, exhibit a diverse range of histological subtypes, each necessitating a nuanced approach to diagnosis and treatment. Within this spectrum, mucinous adenocarcinoma stands as an exceedingly rare variant, and this case report aims to provide a thorough examination of its clinical, radiological, and histopathological dimensions within the context of maxillary sinus malignancies. Surgical resection is considered as treatment of choice for this kind of tumor. A 68-year-old male underwent total maxillectomy using Weber-Ferguson incision for maxillary sinus tumor in our department. The pathological report of tumor was revealed as mucinous type adenocarcinoma. The specimen was observed thoroughly, and based on immunohistochemical findings, diagnosed as mucinous type adenocarcinoma. So, we present a rare case of mucinous type adenocarcinoma arising from the maxillary sinus.

Maxillary sinus cancers, constituting a minority of head and neck malignancies, exhibit a diverse range of histological subtypes, each necessitating a nuanced approach to diagnosis and treatment. Within this spectrum, mucinous adenocarcinoma stands as an exceedingly rare variant, and this case report aims to provide a thorough examination of its clinical, radiological, and histopathological dimensions within the context of maxillary sinus malignancies. Surgical resection is considered as treatment of choice for this kind of tumor. A 68-year-old male underwent total maxillectomy using Weber-Ferguson incision for maxillary sinus tumor in our department. The pathological report of tumor was revealed as mucinous type adenocarcinoma. The specimen was observed thoroughly, and based on immunohistochemical findings, diagnosed as mucinous type adenocarcinoma. So, we present a rare case of mucinous type adenocarcinoma arising from the maxillary sinus.

BACKGROUND: Protein arginine methyltransferase 1 (PRMT1) is a major enzyme responsible for the formation of methylarginine in mammalian cells. Recent studies have revealed that PRMT1 plays important roles in the development of various tissues. However, its role in pancreas development has not yet been elucidated. METHODS: Pancreatic progenitor cell-specific Prmt1 knock-out (Prmt1 PKO) mice were generated and characterized for their metabolic and histological phenotypes and their levels of Neurog3 gene expression and neurogenin 3 (NGN3) protein expression. Protein degradation assays were performed in mPAC cells. RESULTS: Prmt1 PKO mice showed growth retardation and a severely diabetic phenotype. The pancreatic size and β-cell mass were significantly reduced in Prmt1 PKO mice. Proliferation of progenitor cells during the secondary transition was decreased and endocrine cell differentiation was impaired. These defects in pancreas development could be attributed to the sustained expression of NGN3 in progenitor cells. Protein degradation assays in mPAC cells revealed that PRMT1 was required for the rapid degradation of NGN3. CONCLUSION: PRMT1 critically contributes to pancreas development by destabilizing the NGN3 protein.
Animals ; Diabetes Mellitus ; Endocrine Cells ; Gene Expression ; Islets of Langerhans ; Mice ; Pancreas ; Phenotype ; Protein Stability ; Protein-Arginine N-Methyltransferases ; Proteolysis ; Stem Cells

PURPOSE: Fine-needle aspiration biopsy (FNAB) can be used to diagnose thyroid cancer and other tumors. Although FNAB without negative pressure (FNAB−P) reduces the risk of blood contamination, FNAB with negative pressure (FNAB+P) increases the sensitivity of the biopsy results. Therefore, we performed a randomized study of FNAB with or without negative pressure to identify the better diagnostic method. METHODS: Between March 2016 and February 2017, 172 consecutive patients were enrolled to investigate >0.5 cm nodules with indeterminate or suspicious malignant features. Patients were randomly assigned to the FNAB+P group (a 50 mL syringe was used to provide negative pressure) or to the FNAB−P group (passive collection of blood in the needle's hub). The 2 methods' diagnostic adequacy and quality were evaluated using an objective scoring system. The study's protocol was registered with the World Health Organization Clinical Research Information Service (http://cris.nih.go.kr/cris, KCT0001857). RESULTS: The patients were randomly assigned to the FNAB+P group (n = 86) or the FNAB−P group (n = 86). There were no significant intergroup differences in nodule position, size, age, consistency, calcification, BRAF mutation, or pathology. Evaluation of diagnostic adequacy parameters revealed no significant differences in background blood/clot (P = 0.728), amount of cellular material (P = 0.052), degree of cellular degeneration (P = 0.622), degree of cellular trauma (P = 0.979), or retention of appropriate architecture (P = 0.487). Furthermore, there was no significant intergroup difference in the diagnostic quality (P = 0.634). CONCLUSION: This prospective randomized study failed to detect significant differences in the diagnostic adequacy and quality of FNAB with or without negative pressure. Therefore, the examiner may select whichever FNAB method they prefer.
Biopsy ; Biopsy, Fine-Needle ; Cytological Techniques ; Humans ; Information Services ; Methods ; Pathology ; Prospective Studies ; Syringes ; Thyroid Gland ; Thyroid Neoplasms ; Thyroid Nodule ; World Health Organization

Mesalazine suppositories are widely used to treat ulcerative colitis and have a guaranteed safety profile, but although rare, they can cause pulmonary toxicity. A 35-year-old woman with ulcerative colitis was diagnosed to have acute eosinophilic pneumonia after 29 days of oral mesalazine use and improved after mesalazine and corticosteroid were withdrawn. Reintroduction of mesalazine suppositories resulted in acute eosinophilic pneumonia recurrence after 28 days. Mesalazine re-administration (even via a different route) in patients with a history of mesalazine-induced eosinophilic pneumonia should be undertaken cautiously, because eosinophilic pneumonia may recurrence.
Adult ; Colitis, Ulcerative ; Eosinophils ; Female ; Humans ; Mesalamine ; Pulmonary Eosinophilia ; Recurrence ; Suppositories ; Ulcer

No abstract available.
Carcinoma, Basal Cell*

A 32-year old male came to our hospital with chief complaint of paraplegia. He had symptom of radiating pain to right leg 3 months ago before paraplegic symptom appeared. Magnetic resonance (MR) imaging from outside hospital showed intramedullary mass involving from T8 to T10 level of spinal cord. According to the imaging result, tumor removal with total laminectomy was performed between T8 and T10 level in our hospital. Pathologic result was compatible with germinoma. Spine radiation (39.6 Gy/22 fx) from T7 to T12 level without chemotherapy was performed 3 weeks later since tumor removal. Follow-up MR imaging showed no recurrence without any distant metastasis. And our patient's neurologic symptom had been improved. According to this case, postoperative radiotherapy is thought to be effective to primary spinal germinoma.
Drug Therapy ; Follow-Up Studies ; Germinoma* ; Humans ; Laminectomy ; Leg ; Magnetic Resonance Imaging ; Male ; Neoplasm Metastasis ; Neurologic Manifestations ; Paraplegia ; Radiotherapy ; Recurrence ; Spinal Cord* ; Spine