Immediate implant placement and immediate loading in the anterior maxilla is an effective approach to rapidly address aesthetic demands. To achieve successful outcomes, bone quality, soft tissue condition, and accurate implant positioning are essential factors. For optimal results, procedures such as bone augmentation, precise implant placement, and, when necessary, soft tissue grafting should be considered. Furthermore, provisional restoration play a crucial role in achieving the desired appearance of prosthetic restorations and improving the aesthetics of the soft tissue. By performing soft tissue molding through provisional restoration, an ideal emergence profile can be established, which can be subsequently transferred to the final prosthesis, leading to a functional and aesthetically pleasing restoration. This approach aims to optimize the aesthetic outcomes in the anterior region while preserving the natural contours of the peri-implant soft tissue. In this case, a patient requiring extraction of maxillary anterior tooth underwent immediate implantation and alveolar bone grafting using a guide fabricated in advance from CT data. The patient received a provisional restoration on the same day. Subsequent steps included transitioning from the provisional prosthesis to the definitive prosthesis, ultimately achieving an aesthetically pleasing and functional implant restoration. We report this case to highlight the successful approach to maxillary anterior implant rehabilitation.

Immediate implant placement and immediate loading in the anterior maxilla is an effective approach to rapidly address aesthetic demands. To achieve successful outcomes, bone quality, soft tissue condition, and accurate implant positioning are essential factors. For optimal results, procedures such as bone augmentation, precise implant placement, and, when necessary, soft tissue grafting should be considered. Furthermore, provisional restoration play a crucial role in achieving the desired appearance of prosthetic restorations and improving the aesthetics of the soft tissue. By performing soft tissue molding through provisional restoration, an ideal emergence profile can be established, which can be subsequently transferred to the final prosthesis, leading to a functional and aesthetically pleasing restoration. This approach aims to optimize the aesthetic outcomes in the anterior region while preserving the natural contours of the peri-implant soft tissue. In this case, a patient requiring extraction of maxillary anterior tooth underwent immediate implantation and alveolar bone grafting using a guide fabricated in advance from CT data. The patient received a provisional restoration on the same day. Subsequent steps included transitioning from the provisional prosthesis to the definitive prosthesis, ultimately achieving an aesthetically pleasing and functional implant restoration. We report this case to highlight the successful approach to maxillary anterior implant rehabilitation.

Immediate implant placement and immediate loading in the anterior maxilla is an effective approach to rapidly address aesthetic demands. To achieve successful outcomes, bone quality, soft tissue condition, and accurate implant positioning are essential factors. For optimal results, procedures such as bone augmentation, precise implant placement, and, when necessary, soft tissue grafting should be considered. Furthermore, provisional restoration play a crucial role in achieving the desired appearance of prosthetic restorations and improving the aesthetics of the soft tissue. By performing soft tissue molding through provisional restoration, an ideal emergence profile can be established, which can be subsequently transferred to the final prosthesis, leading to a functional and aesthetically pleasing restoration. This approach aims to optimize the aesthetic outcomes in the anterior region while preserving the natural contours of the peri-implant soft tissue. In this case, a patient requiring extraction of maxillary anterior tooth underwent immediate implantation and alveolar bone grafting using a guide fabricated in advance from CT data. The patient received a provisional restoration on the same day. Subsequent steps included transitioning from the provisional prosthesis to the definitive prosthesis, ultimately achieving an aesthetically pleasing and functional implant restoration. We report this case to highlight the successful approach to maxillary anterior implant rehabilitation.

Background: The Korean Society of Thoracic Radiology (KSTR) recently constructed a nation-wide coronavirus disease 2019 (COVID-19) database and imaging repository, referred to the Korean imaging cohort of COVID-19 (KICC-19) based on the collaborative efforts of its members. The purpose of this study was to provide a summary of the clinico-epidemiological data and imaging data of the KICC-19. Methods: The KSTR members at 17 COVID-19 referral centers retrospectively collected imaging data and clinical information of consecutive patients with reverse transcription polymerase chain reaction-proven COVID-19 in respiratory specimens from February 2020 through May 2020 who underwent diagnostic chest computed tomography (CT) or radiograph in each participating hospital. Results: The cohort consisted of 239 men and 283 women (mean age, 52.3 years; age range, 11–97 years). Of the 522 subjects, 201 (38.5%) had an underlying disease. The most common symptoms were fever (n = 292) and cough (n = 245). The 151 patients (28.9%) had lymphocytopenia, 86 had (16.5%) thrombocytopenia, and 227 patients (43.5%) had an elevated CRP at admission. The 121 (23.4%) needed nasal oxygen therapy or mechanical ventilation (n = 38; 7.3%), and 49 patients (9.4%) were admitted to an intensive care unit.Although most patients had cured, 21 patients (4.0%) died. The 465 (89.1%) subjects underwent a low to standard-dose chest CT scan at least once during hospitalization, resulting in a total of 658 CT scans. The 497 subjects (95.2%) underwent chest radiography at least once during hospitalization, which resulted in a total of 1,475 chest radiographs. Conclusion The KICC-19 was successfully established and comprised of 658 CT scans and 1,475 chest radiographs of 522 hospitalized Korean COVID-19 patients. The KICC-19 will provide a more comprehensive understanding of the clinical, epidemiological, and radiologic characteristics of patients with COVID-19.

BACKGROUND: The role of allogeneic hematopoietic cell transplantation (allo-HCT) compared with consolidation chemotherapy alone in intermediate-risk acute myeloid leukemia (AML) patients with wild-type nucleophosmin/negative or a low level of Fms related tyrosine kinase 3 internal tandem duplication (NPM1(wt)/FLT3-ITD(neg/low)) has not yet been elucidated. METHODS: In this study, we retrospectively investigated 88 patients newly diagnosed with AML who received intensive induction chemotherapy at Kyungpook National University Hospital from March 2015 to July 2017. The selection criteria included the presence of results on genetic abnormalities including NPM1 and FLT3-ITD. RESULTS: According to the European LeukemiaNet (ELN) risk classification, 25 patients (28%) were categorized as favorable, 44 (50%) as intermediate, and 19 (22%) as adverse risk. Among the intermediate-risk patients, 40 were identified as NPM1 wt/FLT3-ITDneg/low. Among the patients with NPM1(wt)/FLT3-ITD(neg/low), complete remission (CR) was achieved in 26 patients out of 40 (65%). One-year overall survival (OS) rate was 100% in the favorable-risk group and 87.9% in the NPM1(wt)/FLT3-ITD(neg/low) group (P=0.233). Among the intermediate-risk NPM1(wt)/FLT3-ITD(neg/low) patients, there was no survival benefit with allo-HCT (N=19) compared to consolidation chemotherapy (N=21; P=0.372). In the multivariate analysis, the ELN risk group [hazard ratio (HR), 6.36; P=0.019] and the achievement of CR (HR, 2.95; P=0.017) were both identified as factors affecting OS of patients with newly diagnosed AML. CONCLUSION: Among the AML patients, intermediate-risk NPM1(wt)/FLT3-ITD(neg/low) patients and favorable-risk patients showed similar OS rates. Our results suggested that allo-HCT might have limited clinical benefit for the intermediate-risk NPM1(wt)/FLT3-ITD(neg/low) patients. Well controlled studies are needed to confirm the current results.
Cell Transplantation ; Classification ; Consolidation Chemotherapy ; Gyeongsangbuk-do ; Humans ; Induction Chemotherapy ; Leukemia, Myeloid, Acute ; Multivariate Analysis ; Patient Selection ; Protein-Tyrosine Kinases ; Retrospective Studies ; Transplants

BACKGROUND: Argyria is a rare irreversible cutaneous pigmentation disorder caused by prolonged exposure to silver. Herein, we report a case of generalized argyria that developed after chronic ingestion of soluble silver-nano particles and presented with muscle weakness. CASE PRESENTATION: A 74-year-old woman visited our emergency room, complaining of fever and mental deterioration. She was diagnosed with acute pyelonephritis and recovered after antibiotic therapy. At presentation, diffuse slate gray-bluish pigmented patches were noticed on her face and nails. Two months prior to visiting our hospital, she was diagnosed with inflammatory myopathy and given steroid therapy at another hospital. We performed a nerve conduction study that revealed polyneuropathy. In skin biopsies from pigmented areas of the forehead and nose, the histopathologic results showed brown-black granules in basement membranes of sweat gland epithelia, which are diagnostic findings of argyria. We reviewed pathology slides obtained from the left thigh muscles and found markedly degenerated myofibers with disorganization of myofibrils without inflammatory reactions, consistent with unspecified myopathy, rather than inflammatory myopathy. The patient was diagnosed with generalized argyria with polyneuropathy and myopathy and transferred to a rehabilitation institution after being tapered off of steroids. CONCLUSIONS: Clinicians should be aware of clinical manifestations of argyria and consider it in differential diagnosis when they examine patients who present with skin pigmentation and muscle weakness.
Aged ; Argyria* ; Basement Membrane ; Biopsy ; Diagnosis, Differential ; Eating ; Emergency Service, Hospital ; Female ; Fever ; Forehead ; Humans ; Muscle Weakness* ; Muscles ; Muscular Diseases ; Myofibrils ; Myositis ; Neural Conduction ; Nose ; Pathology ; Pigmentation Disorders ; Polyneuropathies ; Pyelonephritis ; Rehabilitation ; Silver ; Skin ; Skin Pigmentation ; Steroids ; Sweat Glands ; Thigh

OBJECTIVES: This research was carried out to identify the synergistic effect of dexmedetomidine and ketorolac on neuropathic pain alleviation. METHODS: The anti-allodynic effect of intrathecal dexmedetomidine and ketorolac was investigated in rats after L5 spinal nerve ligation (SNL). Mechanical allodynia was assessed using Von Frey filaments. Every day for 3 consecutive days, beginning on the 10th day after SNL, behavioral tests were carried out at 1, 2, and 4 hr after drug injection. RESULTS: Significant increases in ipsilateral paw withdrawal thresholds (PWTs) were observed 1, 2, and 4 hr after drug injection in the groups of rats which received intrathecal injection of either dexmedetomidine (group D) or ketorolac (group K), compared to group S (P < 0.05). And group DK, which received simultaneous intrathecal injection of both dexmedetomidine and ketorolac, showed statistically significantly higher ipsilateral PWTs than groups D and K, which received only one of them (P < 0.05). CONCLUSIONS: The results of this research demonstrated the anti-allodynic effect of dexmedetomidine and ketorolac on neuropathic pain induced by SNL in rats. They also suggest that synergistic analgesia can be induced by the simultaneous injection of dexmedetomidine and ketorolac, and that combination therapy is an effective approach to treating chronic neuropathic pain syndrome.
Analgesia ; Animals ; Behavior Rating Scale ; Dexmedetomidine* ; Hyperalgesia* ; Injections, Spinal ; Ketorolac* ; Ligation* ; Neuralgia ; Rats* ; Spinal Nerves*

It is customary that the dizziness related to cerebral perfusion might be caused by insufficient posterior circulation. The occurrence and nature of dizziness originating from anterior circulation has not been well-known. Here, we report a chronic dizzy woman presenting with severe internal carotid artery stenosis, which improved after carotid artery stenting.
Carotid Arteries ; Carotid Artery, Internal ; Carotid Stenosis ; Dizziness ; Female ; Humans ; Perfusion ; Stents

BACKGROUND: The bacterium Chlamydia trachomatis is one of the leading causes of sexually transmitted diseases worldwide. Since no simple and effective tool exists to diagnose C. trachomatis infections, we evaluated a novel point-of-care (POC) test, aQcare Chlamydia TRF kit, which uses europium-chelated nanoparticles and a time-resolved fluorescence reader. METHODS: The test performance was evaluated by comparing the results obtained using the novel POC testing kit with those obtained using a nucleic acid amplification test (NAAT), using 114 NAAT-positive and 327 NAAT-negative samples. RESULTS: The cut-off value of the novel test was 20.8 with a detection limit of 0.27 ng/mL. No interference or cross-reactivity was observed. Diagnostic accuracy showed an overall sensitivity of 93.0% (106/114), specificity of 96.3% (315/327), positive predictive value (PPV) of 89.8% (106/118), and negative predictive value (NPV) of 97.5% (315/323). The sensitivity of the novel test was much higher than that of currently available POC tests. Furthermore, the relative ease and short turnaround time (30 min) of this assay enables C. trachomatis-infected individuals to be treated without a diagnostic delay. CONCLUSIONS: This simple and novel test is a potential tool to screen a larger population, especially those in areas with limited resources.
Adult ; Aged ; Aged, 80 and over ; Chlamydia Infections/*diagnosis ; Chlamydia trachomatis/*genetics/isolation & purification ; DNA, Bacterial/chemistry/metabolism ; Europium/*chemistry ; Female ; Humans ; Male ; Metal Nanoparticles/*chemistry ; Middle Aged ; Point-of-Care Systems ; Reagent Kits, Diagnostic ; Real-Time Polymerase Chain Reaction ; Sensitivity and Specificity ; Young Adult