【Objective】 To explore the analytical methods for detecting data in the process of quality inspection of blood component samples. 【Methods】 The quality inspection data of blood component samples from 2018 to 2022 in our center were collected. Based on the principles of statistical process control, control charts were created using Minitab software to analyze key test items. 【Results】 The P control chart was used to analyze the pass rate of platelet content and revealed one out-of-control point. The normality test was performed on plasma protein content to analyze the causes of data fluctuations for further improvement. The mean and range control chart was utilized for hematocrit measurement, with abnormal data trends detected. Further analysis of the normality test and process capability analysis was conducted, resulting in a Cpk value of 0.67. 【Conclusion】 By applying statistical process control methods, the study employed P control charts to analyze count data in the quality inspection of blood component samples, conducted normality tests for measurement data, and utilized mean and range control charts to identify abnormal data trends. For data conforming to a normal distribution, the process capability index (Cpk) was calculated to explore effective monitoring methods for ensuring stability in the blood supply process.

Objective:To study the feasibility of 3-D reconstruction model in the observation of tetrachlorodibenzo-p-dioxin(TCDD) effected palatal organ development of fetal mouse.Methods:Kunming mice treated 40 ug/kg TCDD by lavage on day 12.5 of pregnancy were used as in the experimental group,isodose corn oil treated in the control group.On day 13.5,14.5 and 15.5 of pregnancy heads of the fetal mice were taken out and fixed.Conventional paraffin serial sections of palatal organ were preparated and dyed by hematoxylin-eosin,images of the palatal organs were collected and photoshop treated,3-D reconstruction of the palatal organ was performed by 3D-DOCTOR software.Results:3-D reconstruction images showed that palatal organs moved from on both sides above the tongue and gradually closed and merged in the control group.In the experimental group,the palatal organs moved from on both sides above the tongue was later than control group,gradually closed,but not merged,formed cleft palate.Conclusion:3D-DOCTOR software reconstruction can be used for the study of the development process effected by TCDD in the pregnant mouse.

Aim To observe the effects of activation of aldehyde dehydrogenase 2 ( ALDH2 ) by ethanol on testis injury of type 2 diabetic rats. Methods Type 2 diabetic rats model were established by high-fat diet combined with low-dose streptozotocin ( STZ ) injec-tions. After the success of modeling, the rats were ran-domly divided into 3 groups ( n =6 ): normal control group (NC), type 2 diabetes group (T2DM) and eth-anol+type 2 diabetes group (EtOH+T2DM). Rats of EtOH + T2DM were treated with low-dose ethanol, then rats of NC and T2 DM were given normal diet for 8 weeks. After 8 weeks, the levels of the fasting blood glucose ( FBG ) , glycosylated hemoglobin ( HbA1 c ) and testosterone were tested, and the ratio of testis weight to body weight ( TW/BW ) was calculated. Morphological changes of testis tissue were observed by optical microscope. The levels of ALDH2 mRNA and transforming growth factorβ1 ( TGF-β1 ) mRNA in tes-tis tissue were measured. The expression of TGF-β1 in testis tissue was observed by immunohistochemical stai-ning, then the positive rate of TGF-β1 was calculated. Results Compared with NC, the levels of FBG, HbA1 c and TW/BW increased significantly and the level of testosterone decreased significantly in T2DM. The morphological observation showed that some semi-niferous tubules atrophied, spermatogenic cells de-creased and arrangemented loosely, Leydig cells de-creased in testicular interstitial. The level of ALDH2 mRNA in testis tissue decreased significantly, and the level of TGF-β1 mRNA and the positive rate of TGF-β1 in testis tissue increased significantly. However, compared with T2DM, the levels of FBG, HbA1c and TW/BW decreased, and the level of testosterone in-creased and the damage of testis tissue was attenuated in EtOH+T2DM. The level of ALDH2 mRNA in testis tissue increased significantly, and the level TGF-β1 mRNA and the positive rate of TGF-β1 in testis tissue decreased significantly. Conclusion Activating AL-DH2 can protect testis in type 2 diabetic rats, which may be related to the downregulation of TGF-β1 ex-pression.

OBJECTIVETo study the relationship between daily temperature and non-accidental deaths in four districts of Jinan, and to investigate the impact of temperature on cause-specific mortality.

METHODSData on daily mortality of the four districts (Shizhong, Huaiyin, Tianqiao, Lixia) as well as data related to meteorology and air pollution index were collected from January 1, 2008 to December 31, 2012. Distributed lag non-linear model (DLNM) was then used to assess the effects of temperature on all non-accidental deaths and deaths caused by cardiovascular diseases (CVD), respiratory diseases (RD), digestive diseases, urinary diseases, and also subcategories to hypertension, ischemic heart diseases (IHD), acute myocardial infarction (AMI), cerebro-vascular diseases (CBD) and chronic lower respiratory diseases.

RESULTSA W-shaped relationship was noticed between daily average temperature and non-accidental deaths. The effect of low temperature last for more than 30 days, much longer than that of high temperature, in which presented a harvesting effect less than 5 days. As to the cause-specific mortality, short-term heat effects were seen in CVD and RD as well as related subgroups as IHD, CBD and AMI, with RRs at lag 0 as 1.12 (95%CI:1.07-1.17), 1.06 (95% CI:1.02-1.31), 1.08 (95% CI:1.003-1.16), 1.10 (95% CI:1.02-1.20) and 1.13 (95% CI: 1.003-1.26). Relatively higher RRs were seen in urinary diseases and hypertension under extremely high temperature, reaching as high as 2.30 (95%CI:1.18-4.51) and 1.65 (95%CI:1.02-2.69). Cold weather presented a delayed effect for 30 days, with cumulative RRs as 1.51 (95%CI:1.42-1.60), 1.90 (95%CI:1.64-2.20), 2.12 (95%CI:1.67-2.69), 1.48 (95%CI:1.08-2.03), 1.60 (95%CI:1.46-1.75), 1.40 (95%CI:1.26-1.55), 1.68 (95%CI:1.45-1.95) for CVD, RD, chronic lower respiratory diseases, hypertension,IHD, CBD and AMI, on sequence.

CONCLUSIONA relationship was seen between daily temperature and non-accidental deaths as well as cause-specific mortality. Either high or low temperature seemed to be detrimental. Related measures on disease prevention should be taken during the cold and hot seasons.

Cause of Death ; China ; epidemiology ; Humans ; Mortality ; Nonlinear Dynamics ; Temperature

Objective To study the relationship between daily temperature and non-accidental deaths in four districts of Jinan,and to investigate the impact of temperature on cause-specific mortality. Methods Data on daily mortality of the four districts(Shizhong,Huaiyin,Tianqiao,Lixia) as well as data related to meteorology and air pollution index were collected from January 1,2008 to December 31,2012. Distributed lag non-linear model(DLNM)was then used to assess the effects of temperature on all non-accidental deaths and deaths caused by cardiovascular diseases (CVD), respiratory diseases(RD),digestive diseases,urinary diseases,and also subcategories to hypertension, ischemic heart diseases(IHD),acute myocardial infarction(AMI),cerebro-vascular diseases(CBD) and chronic lower respiratory diseases. Results A W-shaped relationship was noticed between daily average temperature and non-accidental deaths. The effect of low temperature last for more than 30 days,much longer than that of high temperature,in which presented a harvesting effect less than 5 days. As to the cause-specific mortality,short-term heat effects were seen in CVD and RD as well as related subgroups as IHD,CBD and AMI,with RRs at lag 0 as 1.12(95%CI:1.07-1.17),1.06 (95%CI:1.02-1.31),1.08(95%CI:1.003-1.16),1.10(95%CI:1.02-1.20) and 1.13 (95%CI:1.003-1.26). Relatively higher RRs were seen in urinary diseases and hypertension under extremely high temperature,reaching as high as 2.30(95%CI:1.18-4.51)and 1.65(95%CI:1.02-2.69). Cold weather presented a delayed effect for 30 days,with cumulative RRs as 1.51(95%CI:1.42-1.60),1.90 (95%CI:1.64-2.20),2.12(95%CI:1.67-2.69),1.48(95%CI:1.08-2.03),1.60(95%CI:1.46-1.75), 1.40(95%CI:1.26-1.55),1.68(95%CI:1.45-1.95)for CVD,RD,chronic lower respiratory diseases, hypertension,IHD,CBD and AMI,on sequence. Conclusion A relationship was seen between daily temperature and non-accidental deaths as well as cause-specific mortality. Either high or low temperature seemed to be detrimental. Related measures on disease prevention should be taken during the cold and hot seasons.

Building a systematic public welfare evaluation index system for public hospitals is key to scientific evaluation of the public welfare positioning of public hospitals and enhancing their public benefit orientation,along with references for government decision making on macro health policies.The indexes were screened and pinpointed in two rounds of Delphi expert consultations,and index weights were determined with the variation coefficient method,initially building a public welfare performance evaluation index system for such hospitals,including eight class-1 indexes and 20 class-2 indexes.Outcomes of the system prove that the public welfare performance indexes of the two hospitals evaluated rise year by year from 2008 to 2010.