Squamous papilloma is a benign mass lesion of the oral mucosa. For papillomas of the tongue, surgery is recommended owing to their malignant potential; however, certain complications may be associated with surgery. A traditional Japanese (Kampo) herbal medicine, Keishibukuryogan-ka-yokuinin (KBGY), has been used to treat viral warts and various skin diseases in Japan. Therefore, the effect of KBGY on papillomas is promising. A 49-year-old Japanese man presented with a wart on his tongue that was about 3 months old. He smoked 5 cigarettes per day. He did not drink alcohol. He had no history of malignant illnesses. He was taking alprazolam for panic disorder. The patient was diagnosed with a suspected papilloma of the tongue at the Department of Otolaryngology and was advised to undergo an excision biopsy to exclude malignancy. However, he refused owing to the fear of an invasive procedure. After informed consent was obtained from the patient, KBGY was prescribed. Three months later, the wart on his tongue spontaneously prolapsed. The histopathological diagnosis was squamous papilloma. There was no indication of malignancy, and the patient discontinued Kampo treatment. He has had no recurrence in the past 3 years. KBGY is a combination of Keishibukuryogan and yokuinin (adlay seeds). Keishibukuryogan may be beneficial for skin or oral mucosal remodeling, and yokuinin may have antiviral properties. The present case report suggests the use of KBGY as an appropriate complementary therapy for squamous papilloma.

Introduction: The importance of estimating the prognosis of advanced cancer patients is well known, but clinicians do not estimate survival time accurately. Since there is a need for an objective index to estimate survival time, the utility of the Prognostic Nutritional Index (PNI), which depends only on objective factors, was evaluated. Methods: The PNI was calculated using the following formula, PNI=10×serum albumin value (g/dL)+0.005×lymphocyte count in peripheral blood, at 3 months, 2 months, 1 month, 3 weeks, 2 weeks, 1 week, and within 3 days before death in 278 cancer patients (166 men, 112 women; age range, 33-99 years; mean age, 69.8 years) who died in a hospital surgical unit. Results: Sites of primary diseases included lung, breast, esophagus, stomach, colorectum, liver, biliary tract, and pancreas. The PNI values showed a gradual decrease over time. Changes in the PNI values were lower in non-gastrointestinal cancer patients than in gastrointestinal cancer patients. The mean PNI value was significantly higher in patients who lived >3 weeks (38.8) than in those who died within 3 weeks (32.4). When the PNI cut-off point was set at 35, and it was assumed that the life expectancy was within 3 weeks in cases with PNI <35, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 74.8%, 62.2%, 68.1%, and 69.6%, respectively. Discussion: The PNI appears to be a useful and simple parameter to predict clinical outcomes of patients with terminal stage cancer. Particularly, the PNI is considered feasible for gastrointestinal cancer patients.

Objective: On the psychological, physiological and immunological parameters, the effects of green tea drink were comprehensively investigated.
Design: This study used a randomized cross-over design.
Methods: After a 120-minute computer fatigue task, participants were randomized into two groups: one tasked to drink green tea and the other water. Blood collection, measurement of the P300 event related potential and questionnaire were executed three times: before and after the computer fatigue task and then, 30 minute after drinking green tea or water. These data were then compared. High Frequency (HF) and average Low Frequency/High Frequency Ratio (LF/HF) were calculated.
Result: In a state of fatigue, drinking green tea showed dominance of the parasympathetic nervous system, an improvement in their attentiveness, and elevation of NK activity; thereby, reducing fatigue, particularly, mental fatigue.
Conclusion: This study comprehensively showed the fatigue-reducing eggect of green tea in psychological, physiological and immunological parameters. It is hereby, suggested that green tea is indeed, helpful in reducing fatigue.

Objective: The psychophysiological and immunological effects of exposure to different varieties of essential oils on fatigue were extensively investigated in students performing personal computer tasks.
Design: Randomized crossover study
Methods: This study was approved by the Kyoto Prefectural University of Medicine Research Ethics Committee, and informed consents were obtained from all subjects. Eight healthy male university students with mean age of 22.38±1.30 (range 21–24) who served as the subjects in this study were given a 120-minute personal computer task with 10-minute rest period before and after the task.
During the course of performing PC task, subjects were either exposed to one of the five essential oil odors (grapefruit, peppermint, true lavender, blend A, blend B) or not exposed to any odor at all, serving as the control in the study. Each of the six odor setting were carried out on separate days upon which psychophysiological and immunological parameters of fatigue in the subjects were evaluated.
Results and Conclusions: The results of this study suggest that exposure to essential oil odors affects the autonomic nervous and immunological system when engaged in a personal computer task. Moreover, different varieties of essential oils cause different vital reactions. In particular, peppermint essential oil exhibits fatigue-reducing effects.

We examined the effect of aromatherapy massage on the circadian rhythm in 8 elderly subjects in an open semi-comparative trial, comparing the parameters in the 2^nd week during which the aromatherapy massage sessions were performed, with 1-week periods (1^st and 3^rd weeks) before and after the sessions. Time spent asleep while in-bed and the sleep efficiency during the sleep time increased significantly in the 2^nd week compared with those in the 1^st and/or 3^rd weeks. A higher peak of the 24-h cycle circadian rhythm was noted following aromatherapy massage in elderly people, who often exhibit circadian rhythm disturbance. Furthermore, the peaks of the spectrum cycle in the 2^nd week were significantly closer to 24 h than those in the 1^st and 3^rd weeks. These results suggest that aromatherapy massage improves sleep and circadian rhythm disturbance.

Objectives: To determine the effects of massage therapy on the immune and psychological state, and serum lipids levels.
Design: A non controlled trial with 32 subjects.
Setting: Kyoto Prefectural School for the Blind and Kyoto Prefectural University of Medicine.
Subjects: 32 adults aged from 18 to 56 years (10 males; 22 females).
Interventions: One 25-min whole body massage.
Outcome Measures: Changes in peripheral blood levels of red blood cells (RBC), hematocrit (Ht), white blood cells (WBC), lymphocytes, neutrophils, CD4+ lymphocytes, CD8+ lymphocytes, CD4+/CD8+ ratio, CD16+ lymphocytes, serum interferon-γ (IFN-γ), serum interleukin 6 (IL6), serum total cholesterol (T-CHO), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c); saliva secretory IgA (s-IgA); State-Trait Anxiety Inventory (STAI).
Results: Psychological measures; Both state and trait anxiety scores decreased significantly (p<0.001). Serum lipids; Significant hemodilution and significantly decreased levels of serum T-CHO, LDLc and HDLc (p<0.001) were observed. Immune measures; Significant decreases of neutrophils (p<0.05) and CD16-positive cell counts (p<0.01) were recognized.
Conclusions: It was suggested from our result in the present study that massage therapy is an effective relaxation/stress management technique which could reduce anxiety and modulate immune function.

In order to examine the attitudes of medical students toward oriental medicine before and after lecture course, self-administered questionnaires were given the medical students of Kyoto Prefectural University of Medicine. Eighteen percent of the students had some experience with the prescription of Kampo medicine by doctors; 53% had used Kampo medicine purchased in pharmacies, and 13% had been treated with acupuncture and moxibustion. Eighty-four percent of the students were interested in oriental medicine; 82% thought that oriental medicine was worth learning; 76% thought that oriental medicine was essential in contemporary medicine and 54% wanted to introduce oriental medicine into their clinical practice in the future. These percentages increased after the lecture course to 92%, 85%, 87% and 62%, respectively.