Dermatomyositis (DM) is a rare systemic autoimmune disorder characterized by distinct skin rash and muscle weakness. Approximately 15%∼30% DM cases present as a paraneoplastic syndrome often associated with an underlying malignancy. Herein, we report the case of a 60-year-old male recently diagnosed with esophageal cancer and exhibited symptoms of DM. The patient presented with generalized muscle weakness and a characteristic skin rash persisting for 3 months. Muscle weakness initially manifested in the proximal arms and later progressed to the proximal legs. In addition, the patient experienced difficulty in swallowing food. Clinical, laboratory, histological, and imaging assessments confirmed the diagnosis of DM associated with esophageal cancer. Notably, both DM and esophageal cancer can cause dysphagia. Therefore, accurate differentiation of dysphagia resulting from malignancy from that resulting from DM is pivotal in the diagnostic process.

Dermatomyositis (DM) is a rare systemic autoimmune disorder characterized by distinct skin rash and muscle weakness. Approximately 15%∼30% DM cases present as a paraneoplastic syndrome often associated with an underlying malignancy. Herein, we report the case of a 60-year-old male recently diagnosed with esophageal cancer and exhibited symptoms of DM. The patient presented with generalized muscle weakness and a characteristic skin rash persisting for 3 months. Muscle weakness initially manifested in the proximal arms and later progressed to the proximal legs. In addition, the patient experienced difficulty in swallowing food. Clinical, laboratory, histological, and imaging assessments confirmed the diagnosis of DM associated with esophageal cancer. Notably, both DM and esophageal cancer can cause dysphagia. Therefore, accurate differentiation of dysphagia resulting from malignancy from that resulting from DM is pivotal in the diagnostic process.

Dermatomyositis (DM) is a rare systemic autoimmune disorder characterized by distinct skin rash and muscle weakness. Approximately 15%∼30% DM cases present as a paraneoplastic syndrome often associated with an underlying malignancy. Herein, we report the case of a 60-year-old male recently diagnosed with esophageal cancer and exhibited symptoms of DM. The patient presented with generalized muscle weakness and a characteristic skin rash persisting for 3 months. Muscle weakness initially manifested in the proximal arms and later progressed to the proximal legs. In addition, the patient experienced difficulty in swallowing food. Clinical, laboratory, histological, and imaging assessments confirmed the diagnosis of DM associated with esophageal cancer. Notably, both DM and esophageal cancer can cause dysphagia. Therefore, accurate differentiation of dysphagia resulting from malignancy from that resulting from DM is pivotal in the diagnostic process.

Dermatomyositis (DM) is a rare systemic autoimmune disorder characterized by distinct skin rash and muscle weakness. Approximately 15%∼30% DM cases present as a paraneoplastic syndrome often associated with an underlying malignancy. Herein, we report the case of a 60-year-old male recently diagnosed with esophageal cancer and exhibited symptoms of DM. The patient presented with generalized muscle weakness and a characteristic skin rash persisting for 3 months. Muscle weakness initially manifested in the proximal arms and later progressed to the proximal legs. In addition, the patient experienced difficulty in swallowing food. Clinical, laboratory, histological, and imaging assessments confirmed the diagnosis of DM associated with esophageal cancer. Notably, both DM and esophageal cancer can cause dysphagia. Therefore, accurate differentiation of dysphagia resulting from malignancy from that resulting from DM is pivotal in the diagnostic process.

Pyoderma gangrenosum (PG) is a neutrophilic dermatosis characterized by non-infectious ulceration of the skin. It is associated with various systemic diseases, including Takayasu arteritis (TA), rheumatoid arthritis, and inflammatory bowel disease. Notably, the co-occurrence of PG and TA is more frequent among Asians. Here, we present a rare case of TA associated with PG. A 42-year-old woman presented with recurrent ulcers affecting her legs, trunk, arms, and face, which had been refractory to various treatments for 7 years. Recently, the patient had experienced weakness in her left leg, dizziness, and a fever that had persisted for more than a month. Computed tomography angiography revealed thickening and irregularities in the common carotid arteries, right subclavian artery, and aortic arch. TA was diagnosed, following which treatment was initiated with systemic corticosteroids. It is important to consider TA in patients with PG, particularly in young women.

Kaposi’s varicelliform eruption (KVE) is a rare viral infection primarily caused by herpes simplex virus (HSV). This condition frequently presents concomitantly with underlying chronic skin disorders, particularly atopic dermatitis (AD). This report describes a rare case of sepsis resulting from KVE in a patient with AD. A 30-year-old male patient with a history of AD presented with painful skin lesions characterized by papulovesicular eruptions, crusts, erythema, and erosions, initially localized to the neck and spreading throughout his body, accompanied by a high fever. Laboratory findings confirmed HSV infection and sepsis. Thus, a diagnosis of KVE compounded by sepsis was established. Systemic acyclovir and antibiotics led to complete recovery within 3 weeks, with resolution of fever and skin manifestations, and general health improvement. Timely recognition and management of KVE are crucial for prevention of adverse outcomes. Both physicians and patients with AD should be made aware of the predisposing factors and risks associated with KVE.