Objective To explore the value of combined detection of lipoprotein(a),TC,TG,LDL-C,HDL-C and uric acid in the diagnosis of coronary artery disease(CHD) in Qinglong Manchu Autonomous County residents.Methods From August 2014 to October 2016,6 640 residents were investigated by stratified sampling,of which 2 000 were suspected to be CHD.Of the 1 200 patients undergoing coronary CT examination,800 patients underwent coronary angiography,of whom 704 were non CHD(non CHD group) and 1 296 were CHD(CHD group).The levels of lipoprotein(a),TC,TG,LDL-C,HDL-C,uric acid and their correlation with CHD were compared between the two groups.Results The levels of TC,LDL-C,lipoprotein(a) and uric acid in patients with CHD were significantly higher than those in non CHD group,while the level of HDL-C decreased significantly(P＜0.05).There was no significant difference in TG levels between the two groups(P＞0.05).The level of blood lipids and uric acid has good predictive value for CHD,and blood lipid level of uric acid in combination with commonly used the positive predictive value was increased.The likelihood of joint detection is higher than single lipid levels or uric acid.The abnormal rates of TC,LDL-C,lipoprotein (a) and uric acid in CHD group were higher than those in non CHD group,and there was no significant difference in the abnormal rates of TG between the two groups.The levels of TC,LDL-C,lipoprotein(a) and uric acid were related to the degree of CHD(P＜ 0.05),but there was no significant correlation between TG and HDL-C and CHD(P＞0.05).Conclusion Combined detection of lipoprotein(a),TC,TG,LDL-C,HDL-C and uric acid can improve the diagnostic accuracy of CHD,and has important diagnostic value.